<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F8VWV8_HUMAN" transmembrane="yes" evidence="3D">
  <Name>ORMDL sphingolipid biosynthesis regulator 2 </Name>
  <CrossRef>
    <PDBTM id="7k0m">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7k0n">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7k0o">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7k0p">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7yiu">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7yiy">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7yj2">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7k0q">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7yj1">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6m4n">
      <Chain id="C"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="6m4o">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7yjo">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7yjk">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7yjm">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7cqi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7cqk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7yjn">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8c80">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8c81">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8c82">
      <Chain id="A"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="8iaj">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="8iak">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="8iam">
      <Chain id="D"/>
      <Chain id="H"/>
    </PDBTM>
    <TOPDB id="ORML3_HUMAN">
      <Alignment>
        <CrossRefSeq>MDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQIHFVLNTVSLMSVLIPKLPQLHGVRIFGINKY</CrossRefSeq>
        <OrigSeq>MDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRVFGINKY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORM1_YEAST">
      <Alignment>
        <CrossRefSeq>IDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRI</CrossRefSeq>
        <OrigSeq>MDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLIN-TASLLSVLLPKLPQFHGVRV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORM2_YEAST">
      <Alignment>
        <CrossRefSeq>INDETLYTPTRKFLLIVPIVLFLISNQYYRNDMTLFLSNLAVTVLIGVVPKLGITHRLRI</CrossRefSeq>
        <OrigSeq>MDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTA-SLLSVLLPKLPQFHGVRV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="65" CheckSum="ae85983bc87e62c937d9fd797af71ab0">
    <Seq>
      MDYGLQFTSS RKFLSISPIV LYLLASFYTK YDAAHFLINT ASLLSVLLPK
      LPQFHGVRVF GINKY
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="92.13">
    <Region from="1" to="13" loc="I"/>
    <Region from="14" to="27" loc="M"/>
    <Region from="28" to="33" loc="O"/>
    <Region from="34" to="48" loc="M"/>
    <Region from="49" to="65" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="12" loc="I"/>
      <Region from="13" to="25" loc="M"/>
      <Region from="26" to="65" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="14" loc="I"/>
      <Region from="15" to="30" loc="M"/>
      <Region from="31" to="34" loc="O"/>
      <Region from="35" to="52" loc="M"/>
      <Region from="53" to="65" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="34" loc="O"/>
      <Region from="35" to="55" loc="M"/>
      <Region from="56" to="65" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="28" loc="M"/>
      <Region from="29" to="65" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="28" loc="M"/>
      <Region from="29" to="33" loc="O"/>
      <Region from="34" to="51" loc="M"/>
      <Region from="52" to="65" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="30" loc="M"/>
      <Region from="31" to="34" loc="O"/>
      <Region from="35" to="55" loc="M"/>
      <Region from="56" to="65" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="6" loc="I"/>
      <Region from="7" to="27" loc="M"/>
      <Region from="28" to="32" loc="O"/>
      <Region from="33" to="54" loc="M"/>
      <Region from="55" to="65" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="12" loc="I"/>
      <Region from="13" to="35" loc="M"/>
      <Region from="36" to="65" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="ORML3_HUMAN">
      <ConstraintRegion from="1" to="26" loc="I" subId="17145335" subSource="7k0m_D"/>
      <ConstraintRegion from="27" to="40" loc="H" subId="17145336" subSource="7k0m_D"/>
      <ConstraintRegion from="41" to="45" loc="O" subId="17145338" subSource="7k0m_D"/>
      <ConstraintRegion from="46" to="62" loc="H" subId="17145340" subSource="7k0m_D"/>
      <ConstraintRegion from="63" to="103" loc="I" subId="17145342" subSource="7k0m_D"/>
      <ConstraintRegion from="104" to="117" loc="H" subId="17145344" subSource="7k0m_D"/>
      <ConstraintRegion from="118" to="121" loc="O" subId="17145346" subSource="7k0m_D"/>
      <ConstraintRegion from="122" to="136" loc="H" subId="17145348" subSource="7k0m_D"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145350" subSource="7k0m_D"/>
      <ConstraintRegion from="1" to="26" loc="I" subId="17145362" subSource="7k0m_H"/>
      <ConstraintRegion from="27" to="40" loc="H" subId="17145363" subSource="7k0m_H"/>
      <ConstraintRegion from="41" to="45" loc="O" subId="17145364" subSource="7k0m_H"/>
      <ConstraintRegion from="46" to="62" loc="H" subId="17145365" subSource="7k0m_H"/>
      <ConstraintRegion from="63" to="103" loc="I" subId="17145366" subSource="7k0m_H"/>
      <ConstraintRegion from="104" to="117" loc="H" subId="17145367" subSource="7k0m_H"/>
      <ConstraintRegion from="118" to="121" loc="O" subId="17145368" subSource="7k0m_H"/>
      <ConstraintRegion from="122" to="136" loc="H" subId="17145369" subSource="7k0m_H"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145370" subSource="7k0m_H"/>
      <ConstraintRegion from="1" to="22" loc="I" subId="17145439" subSource="7k0n_D"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17145441" subSource="7k0n_D"/>
      <ConstraintRegion from="40" to="48" loc="O" subId="17145444" subSource="7k0n_D"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17145447" subSource="7k0n_D"/>
      <ConstraintRegion from="68" to="100" loc="I" subId="17145450" subSource="7k0n_D"/>
      <ConstraintRegion from="101" to="116" loc="H" subId="17145453" subSource="7k0n_D"/>
      <ConstraintRegion from="117" to="123" loc="O" subId="17145457" subSource="7k0n_D"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17145460" subSource="7k0n_D"/>
      <ConstraintRegion from="140" to="153" loc="I" subId="17145463" subSource="7k0n_D"/>
      <ConstraintRegion from="1" to="22" loc="I" subId="17145469" subSource="7k0n_H"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17145471" subSource="7k0n_H"/>
      <ConstraintRegion from="40" to="48" loc="O" subId="17145472" subSource="7k0n_H"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17145474" subSource="7k0n_H"/>
      <ConstraintRegion from="68" to="100" loc="I" subId="17145476" subSource="7k0n_H"/>
      <ConstraintRegion from="101" to="116" loc="H" subId="17145479" subSource="7k0n_H"/>
      <ConstraintRegion from="117" to="123" loc="O" subId="17145482" subSource="7k0n_H"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17145486" subSource="7k0n_H"/>
      <ConstraintRegion from="140" to="153" loc="I" subId="17145490" subSource="7k0n_H"/>
      <ConstraintRegion from="1" to="27" loc="I" subId="17145608" subSource="7k0o_D"/>
      <ConstraintRegion from="28" to="40" loc="H" subId="17145610" subSource="7k0o_D"/>
      <ConstraintRegion from="41" to="45" loc="O" subId="17145612" subSource="7k0o_D"/>
      <ConstraintRegion from="46" to="61" loc="H" subId="17145613" subSource="7k0o_D"/>
      <ConstraintRegion from="62" to="104" loc="I" subId="17145614" subSource="7k0o_D"/>
      <ConstraintRegion from="105" to="117" loc="H" subId="17145615" subSource="7k0o_D"/>
      <ConstraintRegion from="118" to="122" loc="O" subId="17145617" subSource="7k0o_D"/>
      <ConstraintRegion from="123" to="136" loc="H" subId="17145619" subSource="7k0o_D"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145621" subSource="7k0o_D"/>
      <ConstraintRegion from="1" to="27" loc="I" subId="17145668" subSource="7k0o_H"/>
      <ConstraintRegion from="28" to="40" loc="H" subId="17145671" subSource="7k0o_H"/>
      <ConstraintRegion from="41" to="45" loc="O" subId="17145674" subSource="7k0o_H"/>
      <ConstraintRegion from="46" to="61" loc="H" subId="17145677" subSource="7k0o_H"/>
      <ConstraintRegion from="62" to="104" loc="I" subId="17145680" subSource="7k0o_H"/>
      <ConstraintRegion from="105" to="117" loc="H" subId="17145682" subSource="7k0o_H"/>
      <ConstraintRegion from="118" to="122" loc="O" subId="17145684" subSource="7k0o_H"/>
      <ConstraintRegion from="123" to="136" loc="H" subId="17145686" subSource="7k0o_H"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145688" subSource="7k0o_H"/>
      <ConstraintRegion from="1" to="26" loc="I" subId="17145773" subSource="7k0p_D"/>
      <ConstraintRegion from="27" to="40" loc="H" subId="17145776" subSource="7k0p_D"/>
      <ConstraintRegion from="41" to="46" loc="O" subId="17145779" subSource="7k0p_D"/>
      <ConstraintRegion from="47" to="62" loc="H" subId="17145782" subSource="7k0p_D"/>
      <ConstraintRegion from="63" to="103" loc="I" subId="17145785" subSource="7k0p_D"/>
      <ConstraintRegion from="104" to="117" loc="H" subId="17145788" subSource="7k0p_D"/>
      <ConstraintRegion from="118" to="123" loc="O" subId="17145791" subSource="7k0p_D"/>
      <ConstraintRegion from="124" to="136" loc="H" subId="17145794" subSource="7k0p_D"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145797" subSource="7k0p_D"/>
      <ConstraintRegion from="1" to="26" loc="I" subId="17145840" subSource="7k0p_H"/>
      <ConstraintRegion from="27" to="40" loc="H" subId="17145842" subSource="7k0p_H"/>
      <ConstraintRegion from="41" to="45" loc="O" subId="17145843" subSource="7k0p_H"/>
      <ConstraintRegion from="46" to="62" loc="H" subId="17145844" subSource="7k0p_H"/>
      <ConstraintRegion from="63" to="104" loc="I" subId="17145846" subSource="7k0p_H"/>
      <ConstraintRegion from="105" to="117" loc="H" subId="17145848" subSource="7k0p_H"/>
      <ConstraintRegion from="118" to="121" loc="O" subId="17145850" subSource="7k0p_H"/>
      <ConstraintRegion from="122" to="136" loc="H" subId="17145852" subSource="7k0p_H"/>
      <ConstraintRegion from="137" to="153" loc="I" subId="17145854" subSource="7k0p_H"/>
      <ConstraintRegion from="1" to="23" loc="I" subId="17441007" subSource="7yiu_D"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17441008" subSource="7yiu_D"/>
      <ConstraintRegion from="41" to="47" loc="O" subId="17441010" subSource="7yiu_D"/>
      <ConstraintRegion from="48" to="66" loc="H" subId="17441011" subSource="7yiu_D"/>
      <ConstraintRegion from="67" to="99" loc="I" subId="17441012" subSource="7yiu_D"/>
      <ConstraintRegion from="100" to="116" loc="H" subId="17441014" subSource="7yiu_D"/>
      <ConstraintRegion from="117" to="123" loc="O" subId="17441016" subSource="7yiu_D"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17441018" subSource="7yiu_D"/>
      <ConstraintRegion from="140" to="153" loc="I" subId="17441020" subSource="7yiu_D"/>
      <ConstraintRegion from="1" to="23" loc="I" subId="17441063" subSource="7yiy_D"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17441065" subSource="7yiy_D"/>
      <ConstraintRegion from="41" to="46" loc="O" subId="17441067" subSource="7yiy_D"/>
      <ConstraintRegion from="47" to="63" loc="H" subId="17441069" subSource="7yiy_D"/>
      <ConstraintRegion from="64" to="100" loc="I" subId="17441070" subSource="7yiy_D"/>
      <ConstraintRegion from="101" to="117" loc="H" subId="17441071" subSource="7yiy_D"/>
      <ConstraintRegion from="118" to="122" loc="O" subId="17441073" subSource="7yiy_D"/>
      <ConstraintRegion from="123" to="138" loc="H" subId="17441075" subSource="7yiy_D"/>
      <ConstraintRegion from="139" to="153" loc="I" subId="17441077" subSource="7yiy_D"/>
    </Constraint>
  </Constraints>
</HtpItem>
