<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="G3V124_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Transmembrane protease, serine 4, isoform CRA_c </Name>
  <CrossRef>
    <PDBTM id="8vgt">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wqx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jhz">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ji0">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7meq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5ce1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1z8g">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3t2n">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5lyo">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8v1f">
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7xyd">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7y0f">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7y0e">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8hd8">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8v04">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4is5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4isl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4o97">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4o9v">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4r0i">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4jyt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4jz1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4jzi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1eaw">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="1eax">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6n4t">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2gv6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2gv7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3p8g">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3p8f">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4isn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4iso">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3bn9">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3ncl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3nps">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3so3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6t9t">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8g1w">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2oq5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7wqw">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wr7">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8h3u">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1ca0">
      <Chain id="B"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="6kd5">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4dgj">
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6zov">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3dfl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3dfj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1ekb">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3fvf">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3e16">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3gyl">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3e1x">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3e0p">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3e0n">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1o5e">
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="1o5f">
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="3gym">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1p57">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3l33">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="4u32">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5c67">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6gfi">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1zjd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3gis">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3lu9">
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="4ch8">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="4ch2">
      <Chain id="D"/>
    </PDBTM>
    <TOPDB id="TMPS2_HUMAN">
      <Alignment>
        <CrossRefSeq>QASNPVVCTQPKSPSGTVCTSKTKKA--LCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV-----------RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGY--KNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKG</CrossRefSeq>
        <OrigSeq>QPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYY--------FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQE-----LRMRNSSGPCLSGSLVSLHCLACGK---SLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-TDVFNWKVRAGSDKLG---SFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMPSD_HUMAN">
      <Alignment>
        <CrossRefSeq>SLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV-----------RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESA--HRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET</CrossRefSeq>
        <OrigSeq>RIPMETFR--KVGIPIIIALLSLASIII-VVVLIKVILDKYYFLCGQPLHFIPRKQ-LCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGS-FPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENTK_HUMAN">
      <Alignment>
        <CrossRefSeq>HFQCK-NGECVPLVNLCDGHLHCEDGSDEADCVRFFNGT-------TNNNGLVRF--RIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSK--PIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQG</CrossRefSeq>
        <OrigSeq>YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCL--ACGK----SLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHT-DVFNWKVRAGSD---KLGSFPSLA--VAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENTK_BOVIN">
      <Alignment>
        <CrossRefSeq>FQCKDG-ECIPLVNLCDGFPHCKDGSDEAHCVRLFNGTTDSS---------GLVQFRIQSIWHVACAENWTTQISDDVCQLLGLGTGN--SSVPTFSTGGGPYVNLNTAPNGSLILTPSQQCLEDSLILLQCNYKSCGKKLVTQEVSPKIVGGSDSREGAWPWVVALYFDDQQVCGASLVSRDWLVSAAHCVYGRNMEPSKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEMKVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQG</CrossRefSeq>
        <OrigSeq>FLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCL--ACGK----SLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFR-KHTDVFNWKVRAGSD---KLGSFP--SLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ST14_HUMAN">
      <Alignment>
        <CrossRefSeq>HQFTCK-NKFCKPLFWVCDSVNDCGDNSDEQGCS-----CPAQTFRCSNGKCL---SKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGK-----------------EDCSDGS--DEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGG</CrossRefSeq>
        <OrigSeq>YYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALA----ETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLK--TPRVVGVEEASVDSWPWQVSIQ-YDKQHVCGGSILDPHWVLTAAHCFR-----KHTDVFNWKVRAGSDKLGSF-----PSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ST14_MOUSE">
      <Alignment>
        <CrossRefSeq>HQFTCK-NQFCKPLFWVCDSVNDCGDGSDEEGCSCPAG-----SFKCSNGKCLPQSQKC---NGKDNCGDGSDEASCDSVNVVSCTKYTYRCQNGLCLSKGNPECDGKT-----------------DCSDGS--DEKNCDCGLRSFTKQARVVGGTNADEGEWPWQVSLHALGQGHLCGASLISPDWLVSAAHCFQDDKNFKYSDYTMWTAFLGLLDQSKRSASGVQELKLKRIITHPSFNDFTFDYDIALLELEKSVEYSTVVRPICLPDATHVFPAGKAIWVTGWGHTKEGG</CrossRefSeq>
        <OrigSeq>YYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAET----ACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLK--TPRVVGVEEASVDSWPWQVSIQ-YDKQHVCGGSILDPHWVLTAAHCFR-----KHTDVFNWKVRAGSDKLGSF-----PSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TM11D_MOUSE">
      <Alignment>
        <CrossRefSeq>MYRP-RPMLSPSRFFTPFAVAFVVIITVGLLAMMAGLLI---HFLAFDKKAYFYHSSFQILNV--------EYT--EALNSPATHEYRTLSERIEAMITDEFRGSSLKSEFIRTHVVKLRKEGTGVVADVVMKFRSSKRNNRKVMKTRIQSVLRRLSSSGNLEIAPSNEITSLTDQDTENVLTQECGARPDLITLSEERIIGGMQAEPGDWPWQVSLQLNNVHHCGGALISNMWVLTAAHCFKSYPNPQYWTATFGVSTMSPRLRVRVRAILAHDGYSSVTRDNDIAVVQLDRSVAFSRNIHRVCLPAATQNIIPGSVAYVTGWGSLTYGG</CrossRefSeq>
        <OrigSeq>LRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNW------FSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQ-ELRMRNSSGPCLSGSLVSLHCLACGKSLK-----TPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HEPS_HUMAN">
      <Alignment>
        <CrossRefSeq>QEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYG</CrossRefSeq>
        <OrigSeq>EGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGP---DQDLDVVEITE----NSQELRMRNSSGPCLSGSLVSLHCLACGKSL-KTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF-RKHTDVFNWKVRAGSDKLGSFPSLA--VAKIIIIEFN------PMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="PRSS8_HUMAN">
      <Alignment>
        <CrossRefSeq>RSGTGAEGAEAPCGVAP-QARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHV</CrossRefSeq>
        <OrigSeq>LSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPS----LAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFT</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="335" CheckSum="986c8702b560e28fc1a7b24904978550">
    <Seq>
      MDPDSDQPLN SLDVKPLRKP RIPMETFRKV GIPIIIALLS LASIIIVVVL
      IKVILDKYYF LCGQPLHFIP RKQLCDGELD CPLGEDEEHC VKSFPEGPAV
      AVRLSKDRST LQVLDSATGN WFSACFDNFT EALAETACRQ MGYSSKPTFR
      AVEIGPDQDL DVVEITENSQ ELRMRNSSGP CLSGSLVSLH CLACGKSLKT
      PRVVGVEEAS VDSWPWQVSI QYDKQHVCGG SILDPHWVLT AAHCFRKHTD
      VFNWKVRAGS DKLGSFPSLA VAKIIIIEFN PMYPKDNDIA LMKLQFPLTF
      SGTVRPICLP FFDEELTPAT PLWIIGWGFT KQNGG
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="62.38">
    <Region from="1" to="29" loc="I"/>
    <Region from="30" to="51" loc="M"/>
    <Region from="52" to="335" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="55" loc="M"/>
      <Region from="56" to="335" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="41" loc="O"/>
      <Region from="42" to="60" loc="M"/>
      <Region from="61" to="335" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="32" loc="I"/>
      <Region from="33" to="53" loc="M"/>
      <Region from="54" to="225" loc="O"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="335" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="51" loc="M"/>
      <Region from="52" to="335" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="29" loc="O"/>
      <Region from="30" to="51" loc="M"/>
      <Region from="52" to="335" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="30" loc="I"/>
      <Region from="31" to="51" loc="M"/>
      <Region from="52" to="335" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="30" loc="O"/>
      <Region from="31" to="54" loc="M"/>
      <Region from="55" to="335" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="335" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="335" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="31" loc="O"/>
      <Region from="32" to="54" loc="M"/>
      <Region from="55" to="335" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
