<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H0Y9A5_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Tetraspanin </Name>
  <CrossRef>
    <PDBTM id="8esv">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wvg">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7rd5">
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="7rdb">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="I"/>
      <Chain id="K"/>
      <Chain id="L"/>
      <Chain id="M"/>
      <Chain id="N"/>
      <Chain id="P"/>
      <Chain id="Q"/>
      <Chain id="R"/>
      <Chain id="S"/>
      <Chain id="X"/>
      <Chain id="D"/>
      <Chain id="T"/>
      <Chain id="W"/>
      <Chain id="J"/>
      <Chain id="O"/>
      <Chain id="U"/>
      <Chain id="V"/>
    </PDBTM>
    <PDBTM id="6k4j">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="TSN14_HUMAN">
      <Alignment>
        <CrossRefSeq>FTLGFAGCVGA-LRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAG</CrossRefSeq>
        <OrigSeq>FQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVKAN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD63_HUMAN">
      <Alignment>
        <CrossRefSeq>FLVAFVGCCGAC-KENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKI---------PSMSKNRVPDSCCIN------VTVGCGINFNEKA-------IHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRS</CrossRefSeq>
        <OrigSeq>FQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD82_HUMAN">
      <Alignment>
        <CrossRefSeq>LMGFLGCIGAVN-EVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRP------EVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHS</CrossRefSeq>
        <OrigSeq>QEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRD--DIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLEL-----EQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN15_HUMAN">
      <Alignment>
        <CrossRefSeq>FMVSFIGVL-ASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCS--APGPLACGVPYTCCIRNTTE-VVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDI</CrossRefSeq>
        <OrigSeq>FQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD63_MOUSE">
      <Alignment>
        <CrossRefSeq>FLVAFVGCCGAC-KENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENI---------PGMAKDRVPDSCCIN------ITVGCGNDF-------KESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRS</CrossRefSeq>
        <OrigSeq>FQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD82_MOUSE">
      <Alignment>
        <CrossRefSeq>FLGCIGAVN-EVRCLLGLYFVFLLLILIAQVTVGVLFYFNADKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFT------KTTYPCSCEKIKEEDNQLIVKKGFCEADNSTVSENNPEDWPVNTEGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHS</CrossRefSeq>
        <OrigSeq>EVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAY--RDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGF----IHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD151_HUMAN">
      <Alignment>
        <CrossRefSeq>VLGCC-ATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRV----VPDSCCK------TVVALCGQRDHASNIYKVEG-----GCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLK</CrossRefSeq>
        <OrigSeq>EVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVK---AYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN6_MOUSE">
      <Alignment>
        <CrossRefSeq>GCFATCRTSAW-MLKLYAMFLTLIFLVELVAAIVGFVFRHEIKNSFKSNYENALKEYNSTGDYRSEAVDKIQSTLHCCGVTNYGDWKGTNYYS---------ETGFPKSCCKLEGCYP---------------QRDADKVNEEGCFIKVMTTIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQ</CrossRefSeq>
        <OrigSeq>GCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQ-NLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN3_HUMAN">
      <Alignment>
        <CrossRefSeq>FIIGLIGCC-ATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKET------KNQSVPLSCCRETA------------SNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCR</CrossRefSeq>
        <OrigSeq>FQEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDID--LQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD53_HUMAN">
      <Alignment>
        <CrossRefSeq>VVAFLGCMGS-IKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTS----------------GPPASC--------------------------PSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDK</CrossRefSeq>
        <OrigSeq>QEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD9_HUMAN">
      <Alignment>
        <CrossRefSeq>LVGFLGCCGA-VQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAG--------------------------------GVEQFISDICPKK-------DVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNR</CrossRefSeq>
        <OrigSeq>QEPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYR-DDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN8_HUMAN">
      <Alignment>
        <CrossRefSeq>LGFLGCCGA-IKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQ-------------HYPELCACLDKQRP-------------CQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQI</CrossRefSeq>
        <OrigSeq>EPEVGCCGKYFLFGFNIVFWFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDID----LQNLIDFAQEYWSCCG-ARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDI</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="203" CheckSum="a949019899f7f0627560ad3482ef652f">
    <Seq>
      XGKHQHFQEP EVGCCGKYFL FGFNIVFWFS VFLGLIFFLE LATGILAFVF
      KDWIRDQLNL FINNNVKAYR DDIDLQNLID FAQEYWSCCG ARGPNDWNLN
      IYFNCTDLNP SRERCGVPFS CCVRDPAEDV LNTQCGYDVR LKLELEQQGF
      IHTKGCVGQF EKWLQDNLIV VAGVFMGIAL LQIFGICLAQ NLVSDIKAVK
      ANW
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="68.16">
    <Region from="1" to="21" loc="I"/>
    <Region from="22" to="49" loc="M"/>
    <Region from="50" to="166" loc="O"/>
    <Region from="167" to="189" loc="M"/>
    <Region from="190" to="203" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="6" loc="O"/>
      <Region from="7" to="26" loc="M"/>
      <Region from="27" to="28" loc="I"/>
      <Region from="29" to="49" loc="M"/>
      <Region from="50" to="167" loc="O"/>
      <Region from="168" to="189" loc="M"/>
      <Region from="190" to="203" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="49" loc="M"/>
      <Region from="50" to="164" loc="O"/>
      <Region from="165" to="191" loc="M"/>
      <Region from="192" to="203" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="34" loc="M"/>
      <Region from="35" to="35" loc="O"/>
      <Region from="36" to="50" loc="M"/>
      <Region from="51" to="162" loc="I"/>
      <Region from="163" to="177" loc="M"/>
      <Region from="178" to="178" loc="O"/>
      <Region from="179" to="193" loc="M"/>
      <Region from="194" to="203" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="25" loc="O"/>
      <Region from="26" to="50" loc="M"/>
      <Region from="51" to="167" loc="I"/>
      <Region from="168" to="189" loc="M"/>
      <Region from="190" to="203" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="24" loc="O"/>
      <Region from="25" to="50" loc="M"/>
      <Region from="51" to="167" loc="I"/>
      <Region from="168" to="193" loc="M"/>
      <Region from="194" to="203" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="167" loc="O"/>
      <Region from="168" to="188" loc="M"/>
      <Region from="189" to="203" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="26" loc="I"/>
      <Region from="27" to="47" loc="M"/>
      <Region from="48" to="168" loc="O"/>
      <Region from="169" to="189" loc="M"/>
      <Region from="190" to="203" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="39" loc="M"/>
      <Region from="40" to="167" loc="O"/>
      <Region from="168" to="188" loc="M"/>
      <Region from="189" to="203" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="22" loc="I"/>
      <Region from="23" to="43" loc="M"/>
      <Region from="44" to="167" loc="O"/>
      <Region from="168" to="188" loc="M"/>
      <Region from="189" to="203" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="27" loc="O"/>
      <Region from="28" to="50" loc="M"/>
      <Region from="51" to="167" loc="I"/>
      <Region from="168" to="190" loc="M"/>
      <Region from="191" to="203" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
