<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H0YCA2_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 22 member 25 </Name>
  <CrossRef>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jts">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtt">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>AFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN----------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFR</CrossRefSeq>
        <OrigSeq>AFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLS----------SPNHVSTDCDEGLEVPIAIH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>AFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANAN----------LSKDGGLEAWLPLDKQGRPESCLRFPFP------HNGTEANGTGV-TEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFR</CrossRefSeq>
        <OrigSeq>AFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLS----------SPNHVSTDCDEGLEVPIAIH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22AB_HUMAN">
      <Alignment>
        <CrossRefSeq>AFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSA---VSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAF</CrossRefSeq>
        <OrigSeq>AFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPN----------HVSTDCDEGLEVPIAIHQHHVF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>GFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPG--------APANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAIT</CrossRefSeq>
        <OrigSeq>AFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNT-----SEPDTEPCVDGWVYDQSSFPSTIVT--KWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIAIHQHHVFWYLS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCTN2_HUMAN">
      <Alignment>
        <CrossRefSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS-----------AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVV</CrossRefSeq>
        <OrigSeq>FQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPF---DSNLRPEKCRRFVHPQWKLIHLNGTFPNT----SEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIAIHQHHVFWYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORCT_DROME">
      <Alignment>
        <CrossRefSeq>GYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPH-------LWNLSYPEN-----ERCS-YYDVDYTEEYLNGSIPRSSN-ETKTCSS-YVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTIS</CrossRefSeq>
        <OrigSeq>AFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIAIHQHHVFWYLS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCT1_CAEEL">
      <Alignment>
        <CrossRefSeq>FDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHTCHIP------------------EGKEYLRPLTNDTQILSCKQYNETQINVFRAFTSAPVDTYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILR</CrossRefSeq>
        <OrigSeq>FQDLLDQVGGLGRFQILQMVFLIMF-NVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFP---NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSS----------PNHVSTDCDEGLEVPIAIH</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="202" CheckSum="f1f2a4435fcd16e88c4c502643d9adb2">
    <Seq>
      XAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW
      VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH
      LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF
      LFMAGMMVGG NLYGHLSDRK PLSSPNHVST DCDEGLEVPI AIHQHHVFWY
      LS
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="59.49">
    <Region from="1" to="10" loc="I"/>
    <Region from="11" to="31" loc="M"/>
    <Region from="32" to="202" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="31" loc="M"/>
      <Region from="32" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="18" loc="O"/>
      <Region from="19" to="43" loc="M"/>
      <Region from="44" to="147" loc="I"/>
      <Region from="148" to="166" loc="M"/>
      <Region from="167" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="145" loc="O"/>
      <Region from="146" to="166" loc="M"/>
      <Region from="167" to="180" loc="I"/>
      <Region from="181" to="201" loc="M"/>
      <Region from="202" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="12" loc="I"/>
      <Region from="13" to="33" loc="M"/>
      <Region from="34" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="11" loc="O"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="202" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="146" loc="O"/>
      <Region from="147" to="167" loc="M"/>
      <Region from="168" to="178" loc="I"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="146" loc="O"/>
      <Region from="147" to="167" loc="M"/>
      <Region from="168" to="176" loc="I"/>
      <Region from="177" to="197" loc="M"/>
      <Region from="198" to="202" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="32" loc="M"/>
      <Region from="33" to="202" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
