<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H0YHD6_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Acid sensing ion channel subunit 1 </Name>
  <CrossRef>
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      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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    <PDBTM id="4nyk">
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    <PDBTM id="4ntw">
      <Chain id="A"/>
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      <Chain id="G"/>
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    <PDBTM id="4ntx">
      <Chain id="A"/>
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      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
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      <Chain id="B"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="E"/>
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    <PDBTM id="3s3x">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
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    <PDBTM id="6l6n">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
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    <PDBTM id="8on7">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
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    <PDBTM id="8on8">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
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    <PDBTM id="8on9">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8ona">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7yvc">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7yvb">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="ASIC1_CHICK">
      <Alignment>
        <CrossRefSeq>ENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCRKNHKRNNTDKGVALSMDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNB_RAT">
      <Alignment>
        <CrossRefSeq>KGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPNAEVYPDQQTLPIPGTPPPNY</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCR-----RGKCQKEAKRSSADKGVALS--LDDVKRHNPCESLR---------GHPAGMTYAANILPHH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNB_HUMAN">
      <Alignment>
        <CrossRefSeq>KGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNY</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCR-----RGKCQKEAKRSSADKGVALS--LDDVKRHNPCESLRGHP---------AGMTYAANILPHH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNA_HUMAN">
      <Alignment>
        <CrossRefSeq>GVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATL</CrossRefSeq>
        <OrigSeq>NILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEA-------KRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP-HHPARGTF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNG_RAT">
      <Alignment>
        <CrossRefSeq>DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKAKDWWARRQTPPSTETPSSRQGQDNPALDTDDDLPTFTSAMRLPPAP-GSTVPGTPPPRYNTLRLDRAFS</CrossRefSeq>
        <OrigSeq>NILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVI--------KHKLCRRGKCQKEAK-------RSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNG_HUMAN">
      <Alignment>
        <CrossRefSeq>DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPA-LGTQVPGTPPPKYNTLRLERAFS</CrossRefSeq>
        <OrigSeq>NILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKR---------------SSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNNA_RAT">
      <Alignment>
        <CrossRefSeq>GVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLRRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQ</CrossRefSeq>
        <OrigSeq>NILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKH-------KLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="UN105_CAEEL">
      <Alignment>
        <CrossRefSeq>KNAAMVQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLIV----FATQAYVRKRKGSISAQSHHSVPVHRASRVSLNTLHKSSTTQSVKLSVMDIRSIKSIHSNHSSKS</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADK------GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MEC4_CAEBR">
      <Alignment>
        <CrossRefSeq>ENGAMVEVFYEQLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFLETAYMSAEHNY</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MEC4_CAEEL">
      <Alignment>
        <CrossRefSeq>ENGAMVEVFYEQLNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFLETAYMSAEHNY</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DEL10_CAEEL">
      <Alignment>
        <CrossRefSeq>DNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEIVYL---CIQYGLCGKRARNMKCIPMDALTRQMKKVATCS</CrossRefSeq>
        <OrigSeq>ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKC-----QKEAKRSSADKGVALS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="127" CheckSum="11718b3610c254c627aef2509adefd32">
    <Seq>
      XENILVLDIF FEVLNYETIE QKKAYEIAGL LGDIGGQMGL FIGASILTVL
      ELFDYAYEVI KHKLCRRGKC QKEAKRSSAD KGVALSLDDV KRHNPCESLR
      GHPAGMTYAA NILPHHPARG TFEDFTC
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="93.43">
    <Region from="1" to="37" loc="O"/>
    <Region from="38" to="56" loc="M"/>
    <Region from="57" to="127" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="39" loc="O"/>
      <Region from="40" to="57" loc="M"/>
      <Region from="58" to="127" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="30" loc="O"/>
      <Region from="31" to="60" loc="M"/>
      <Region from="61" to="127" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="13" loc="L"/>
      <Region from="14" to="26" loc="O"/>
      <Region from="27" to="57" loc="M"/>
      <Region from="58" to="127" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="37" loc="O"/>
      <Region from="38" to="57" loc="M"/>
      <Region from="58" to="127" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="34" loc="O"/>
      <Region from="35" to="55" loc="M"/>
      <Region from="56" to="127" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="39" loc="O"/>
      <Region from="40" to="60" loc="M"/>
      <Region from="61" to="127" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8on7_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887651" subSource="8on7_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887652" subSource="8on7_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887653" subSource="8on7_A"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887654" subSource="8on7_A"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887655" subSource="8on7_A"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887657" subSource="8on7_A"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887658" subSource="8on7_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887659" subSource="8on7_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887662" subSource="8on7_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887663" subSource="8on7_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887664" subSource="8on7_B"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887665" subSource="8on7_B"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887666" subSource="8on7_B"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887668" subSource="8on7_B"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887669" subSource="8on7_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887670" subSource="8on7_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887673" subSource="8on7_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887674" subSource="8on7_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887675" subSource="8on7_C"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887676" subSource="8on7_C"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887677" subSource="8on7_C"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887679" subSource="8on7_C"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887680" subSource="8on7_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887681" subSource="8on7_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8on8_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887684" subSource="8on8_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887685" subSource="8on8_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887686" subSource="8on8_A"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887687" subSource="8on8_A"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887688" subSource="8on8_A"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887690" subSource="8on8_A"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887691" subSource="8on8_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887692" subSource="8on8_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887695" subSource="8on8_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887696" subSource="8on8_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887697" subSource="8on8_B"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887698" subSource="8on8_B"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887699" subSource="8on8_B"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887701" subSource="8on8_B"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887702" subSource="8on8_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887703" subSource="8on8_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887706" subSource="8on8_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887707" subSource="8on8_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887708" subSource="8on8_C"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887709" subSource="8on8_C"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887710" subSource="8on8_C"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887712" subSource="8on8_C"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887713" subSource="8on8_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887714" subSource="8on8_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8on9_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887717" subSource="8on9_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887718" subSource="8on9_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887719" subSource="8on9_A"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887720" subSource="8on9_A"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887721" subSource="8on9_A"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887723" subSource="8on9_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887724" subSource="8on9_A"/>
      <ConstraintRegion from="513" to="528" loc="H" subId="20887725" subSource="8on9_A"/>
      <ConstraintRegion from="529" to="530" loc="I" subId="20887726" subSource="8on9_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887729" subSource="8on9_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887730" subSource="8on9_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887731" subSource="8on9_B"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887732" subSource="8on9_B"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887733" subSource="8on9_B"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887735" subSource="8on9_B"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887736" subSource="8on9_B"/>
      <ConstraintRegion from="513" to="528" loc="H" subId="20887737" subSource="8on9_B"/>
      <ConstraintRegion from="529" to="530" loc="I" subId="20887738" subSource="8on9_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887741" subSource="8on9_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887742" subSource="8on9_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887743" subSource="8on9_C"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887744" subSource="8on9_C"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887745" subSource="8on9_C"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887747" subSource="8on9_C"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887748" subSource="8on9_C"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887749" subSource="8on9_C"/>
      <ConstraintRegion from="528" to="530" loc="I" subId="20887750" subSource="8on9_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8ona_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887753" subSource="8ona_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887754" subSource="8ona_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887755" subSource="8ona_A"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887756" subSource="8ona_A"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887757" subSource="8ona_A"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887759" subSource="8ona_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887760" subSource="8ona_A"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887761" subSource="8ona_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887762" subSource="8ona_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887765" subSource="8ona_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887766" subSource="8ona_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887767" subSource="8ona_B"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887768" subSource="8ona_B"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887769" subSource="8ona_B"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887771" subSource="8ona_B"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887772" subSource="8ona_B"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887773" subSource="8ona_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887774" subSource="8ona_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887777" subSource="8ona_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887778" subSource="8ona_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887779" subSource="8ona_C"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887780" subSource="8ona_C"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887781" subSource="8ona_C"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887783" subSource="8ona_C"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887784" subSource="8ona_C"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887785" subSource="8ona_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887786" subSource="8ona_C"/>
    </Constraint>
  </Constraints>
</HtpItem>
