Two pore segment channel 1 LLAVVFDTFNDIEKHKFKSLLLHKRTAIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFYFI LLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETF------------------MLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFI ILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVP-SLFEHFPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETAT LLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRP---AGISYRQFEGLMRFYK-PRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPR-TALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETF------------------MLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLAL VRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET-------------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFLGLLALALNMEPF VRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRTL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET-------------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFLGLLALALNMEPF VRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET-------------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFLGLLALALNMEPF KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFT KKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVET-----------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFLGLLAL KPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFT KKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVET-----------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFLGLLAL KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAIL ALLIFKGINILVKSKAFQYFMYLVVAVNGVWIL-------------------VETFMLKVYGVELFLKVAGLG----PVEYLSSGWNLFDFSVTVFAFLGLLA DEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNI EVAALKWKAKKNREHWFDELPRT------ALLIFKGINILVKSKAFQYFMYLVVAVNGVWILV-------------------ETFMLKVYGVELFLKVAGLGP----VEYLSSGWNLFDFSVTVFAFLGLLALALNM DEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVN EVAALKWKAKKNREHWFDELPRT------ALLIFKGINILVKSKAFQYFMYLVVAVNGVWILV-------------------ETFMLKVYGVELFLKVAGLGP----VEYLSSGWNLFDFSVTVFAFLGLLALALN KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAIL ALLIFKGINILVKSKAFQYFMYLVVAVNGVWIL-------------------VETFMLKVYGVELFLKVAGLG----PVEYLSSGWNLFDFSVTVFAFLGLLA NPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM LLIFKGINILVKSKAFQYFMYLVVAVNGVWILVET-------------------FMLKVYGVELFLKVAGLGPV----EYLSSGWNLFDFSVTVFAFL KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAIL ALLIFKGINILVKSKAFQYFMYLVVAVNGVWIL-------------------VETFMLKVYGVELFLKVAGLG----PVEYLSSGWNLFDFSVTVFAFLGLLA VRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT IFKGINILVKSKAFQYFMYLVVAVNGVWILVET-------------------FMLKVYGVELFLKVAGLGP----VEYLSSGWNLFDFSVTVFAFLGLLALALNM NPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET LLIFKGINILVKSKAFQYFMYLVVAVNGVWIL-------------------VETFMLKVYGVELFLKVAGLG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEP LRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTL IFKGINILVKSKAFQYFMYLVVAVNGVWILVETF------------------MLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTL IFKGINILVKSKAFQYFMYLVVAVNGVWILVETF------------------MLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL ISFAQKYLIWECCPKWRKFKMALFE----LVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSA LKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETF----------------MLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLA LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANAL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET------------------FMLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANAL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET------------------FMLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANAL IFKGINILVKSKAFQYFMYLVVAVNGVWILVET------------------FMLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV KAKKNREHWFDELPRTALLIFKG------------INILVKSKAFQYFMYLVVAVNGVWILVET----------------FMLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVA IFKGINILVKSKAFQYFMYLVVAVNGVWILVET------------------FMLKVYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLA XLLAVVFDTF NDIEKRKFKS LLLHKRTAIQ HAYRLLISQR RPAGISYRQF EGLMRFYKPR MSARERYLTF KALNQNNTPL LSLKDFYDIY EVAALKWKAK KNREHWFDEL PRTALLIFKG INILVKSKAF QYFMYLVVAV NGVWILVETF MLKVYGVELF LKVAGLGPVE YLSSGWNLFD FSVTVFAFLG LLALALNMEP FYFI