<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H0YK69_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>KEASKDRILKKIQQKKEIIQKLRGQPWYMKRKRRTLKVAQKHLQQQEAKVSKARLYKAEAGRRLTQASRWLDNLKIYLIPWEAKIRKIESHFGSVVSSYFTFHRWVLGVNITITFIMCMFVVIPEWLADSRTQFGDDRYNKTKAIKVMPPAVRARADELSTVWDFGGYFQYSLLFYGFYSKETFFGETIKYRVPVAYFFCNIFILGFSLFIILRKMAANNRRGTLSSGKTQQYLFNWKAFTGWDYTIGNPETAGNVYMANVIKFREAINDDKQKPSDKHPWIRFVARVLTNLFICAMYVFSIWAI---------MQCGTLKGEHFFAQNATAITISLITLVFPNIFDLLGKIEKLHPRNALRFQLGRVLVLYILNYYTLIYSLMLQLEHLQKEKNASDNPISALGHPGDAIGRTIRETVLPRYPVDNNPHTYYSYAPVTTTPIPATSSWTTVLPDFGPFGVYNPKASVTKDDTVFSSPVVETHMFGPNSDWNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVSSDDDSQHNRSTAKSVSGRQFV-PSLGSVSEVDHSTGEEQSSDSESTTSSLPPKLSLRQRFLVCIGWADPNKYGRHDDIEMEEGGGRLRELSTGSETDSDDEDSEKSNRDMSYRTAIQSFDQNSQSASASSSKSTTTAPSNSEMRIEITENPLHTYITPLRIEKKSSASSSSSSHQPSSSIEKQAARRLLQPISTTHNIRYGVATVENSSQDPTRPPSTDDSLG----DPALHEPLWANLNPHSSY----TSAMMSPIMNEVMSNDETTDDEKGRLIPDRPPIPHSPRELKRLKREKDQQSESGSKPSTPR-PPRFRISMSPPRK--PPSEKNDSDSSNRKY</CrossRefSeq>
        <OrigSeq>DSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEGRLTRTRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAG--------QPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIG-RAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSR-TSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEQVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKN---------------------------NTSHWIDSTTFFATRTAPEEEKWSTSRPGMGL-RRNNTWALEETSISAYTMPLIKANKTSLHTQ----------------------SPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQMVEARIQTQEESTKKLPNDSDL--------TSQLSSAHSGTPQNNGNVAHFDSGSSKSGRIETVAQSMPQSPRPGDRAPSSPLPGVPKSRL-----EHETNRYLH------------------GLCASTSDLHRNRSRTPMTFTTHIEDVHSEPLFRKDFQQINPPHRGPQASTLLAQGPRPHAPRYYVINECDSYKKKHLNVWPERHFKIDASGDIVELYP----RNVRQYASRVPRQPPSPQLSEEEEETPSRDWIKRSLPPRSLIDLRRAPHFYIGERSESQTRDPEHQGRVHYKSWNEDFEGHLERPAYVP--------RKPRSRNFQYPQPPLKPRGKPRFEPSLTESDSVSAASSSDQQNSSADQY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>RLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDN-TFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAP----------------------------FFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKM</CrossRefSeq>
        <OrigSeq>QIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEGRLTR-----TRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEQVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPEEEKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQM</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="1101" CheckSum="bc7cd7d0c7e3ab567686aef06e92fb2b">
    <Seq>
      MKTSKASQRY RGIRRNASQC YLYQESLLLS NLDDSFSADE TGDSNDPEQI
      FQNIQFQKDL MANIRCRPWT MGQKLRALRQ AKNIVLKFEG RLTRTRGYQA
      AGAELWRKFA RLACNFVVIF IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG
      INIVLTIMTG AFIVIPELIA GQPFGSTARK TIPKEQVSSA QDLDTVWSLG
      GYLQYSVLFY GYYGRERKIG RAGYRLPLAY FLVGMAVFAY SFIILLKKMA
      KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AIVNSIREAI
      LEEQEKKKSK NLAVTICLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS
      KKELTLWEKN EQVSVVVSLV TMIAPSAFDL IAALEMYHPR TTLRFQLARV
      LVLYLGNLYS LIIALLDKVN SMSIEEMATK NNTSHWIDST TFFATRTAPE
      EEKWSTSRPG MGLRRNNTWA LEETSISAYT MPLIKANKTS LHTQSPQDQC
      WETYVGQEML KLSIIDMLFT VASILLIDFF RGLFVRYLSD YWCWDLESKF
      PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA
      VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VRYKPSLNCG
      PFSGQEKIYD IVSETIEKDF PVWFGSVVGH ISSPVVILPA VLLLFMLIYY
      LQSIARSLKL SNHQLKMQIQ NARSEDKKKV AQMVEARIQT QEESTKKLPN
      DSDLTSQLSS AHSGTPQNNG NVAHFDSGSS KSGRIETVAQ SMPQSPRPGD
      RAPSSPLPGV PKSRLEHETN RYLHGLCAST SDLHRNRSRT PMTFTTHIED
      VHSEPLFRKD FQQINPPHRG PQASTLLAQG PRPHAPRYYV INECDSYKKK
      HLNVWPERHF KIDASGDIVE LYPRNVRQYA SRVPRQPPSP QLSEEEEETP
      SRDWIKRSLP PRSLIDLRRA PHFYIGERSE SQTRDPEHQG RVHYKSWNED
      FEGHLERPAY VPRKPRSRNF QYPQPPLKPR GKPRFEPSLT ESDSVSAASS
      SDQQNSSADQ YLQVTHSQGR FPRSVGQPSR RKAKSGQELT VDLDDLICSD
      V
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="79.74">
    <Region from="1" to="141" loc="I"/>
    <Region from="142" to="164" loc="M"/>
    <Region from="165" to="224" loc="O"/>
    <Region from="225" to="245" loc="M"/>
    <Region from="246" to="316" loc="I"/>
    <Region from="317" to="337" loc="M"/>
    <Region from="338" to="362" loc="O"/>
    <Region from="363" to="382" loc="M"/>
    <Region from="383" to="394" loc="I"/>
    <Region from="395" to="416" loc="M"/>
    <Region from="417" to="571" loc="O"/>
    <Region from="572" to="593" loc="M"/>
    <Region from="594" to="619" loc="I"/>
    <Region from="620" to="640" loc="M"/>
    <Region from="641" to="680" loc="O"/>
    <Region from="681" to="701" loc="M"/>
    <Region from="702" to="1101" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="147" loc="O"/>
      <Region from="148" to="165" loc="M"/>
      <Region from="166" to="225" loc="I"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="684" loc="O"/>
      <Region from="685" to="705" loc="M"/>
      <Region from="706" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="169" loc="M"/>
      <Region from="170" to="225" loc="O"/>
      <Region from="226" to="249" loc="M"/>
      <Region from="250" to="315" loc="I"/>
      <Region from="316" to="340" loc="M"/>
      <Region from="341" to="362" loc="O"/>
      <Region from="363" to="380" loc="M"/>
      <Region from="381" to="394" loc="I"/>
      <Region from="395" to="417" loc="M"/>
      <Region from="418" to="508" loc="O"/>
      <Region from="509" to="539" loc="M"/>
      <Region from="540" to="563" loc="I"/>
      <Region from="564" to="585" loc="M"/>
      <Region from="586" to="588" loc="O"/>
      <Region from="589" to="604" loc="M"/>
      <Region from="605" to="618" loc="I"/>
      <Region from="619" to="641" loc="M"/>
      <Region from="642" to="678" loc="O"/>
      <Region from="679" to="704" loc="M"/>
      <Region from="705" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="136" loc="O"/>
      <Region from="137" to="167" loc="M"/>
      <Region from="168" to="186" loc="I"/>
      <Region from="187" to="207" loc="M"/>
      <Region from="208" to="224" loc="O"/>
      <Region from="225" to="245" loc="M"/>
      <Region from="246" to="317" loc="I"/>
      <Region from="318" to="338" loc="M"/>
      <Region from="339" to="358" loc="O"/>
      <Region from="359" to="379" loc="M"/>
      <Region from="380" to="388" loc="I"/>
      <Region from="389" to="419" loc="M"/>
      <Region from="420" to="507" loc="O"/>
      <Region from="508" to="522" loc="M"/>
      <Region from="523" to="523" loc="I"/>
      <Region from="524" to="538" loc="M"/>
      <Region from="539" to="563" loc="O"/>
      <Region from="564" to="594" loc="M"/>
      <Region from="595" to="616" loc="I"/>
      <Region from="617" to="637" loc="M"/>
      <Region from="638" to="673" loc="O"/>
      <Region from="674" to="704" loc="M"/>
      <Region from="705" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="142" loc="I"/>
      <Region from="143" to="165" loc="M"/>
      <Region from="166" to="195" loc="O"/>
      <Region from="196" to="214" loc="M"/>
      <Region from="215" to="225" loc="I"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="319" loc="O"/>
      <Region from="320" to="341" loc="M"/>
      <Region from="342" to="361" loc="I"/>
      <Region from="362" to="383" loc="M"/>
      <Region from="384" to="394" loc="O"/>
      <Region from="395" to="416" loc="M"/>
      <Region from="417" to="513" loc="I"/>
      <Region from="514" to="535" loc="M"/>
      <Region from="536" to="570" loc="O"/>
      <Region from="571" to="593" loc="M"/>
      <Region from="594" to="619" loc="I"/>
      <Region from="620" to="641" loc="M"/>
      <Region from="642" to="679" loc="O"/>
      <Region from="680" to="701" loc="M"/>
      <Region from="702" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="137" loc="I"/>
      <Region from="138" to="165" loc="M"/>
      <Region from="166" to="195" loc="O"/>
      <Region from="196" to="214" loc="M"/>
      <Region from="215" to="225" loc="I"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="319" loc="O"/>
      <Region from="320" to="341" loc="M"/>
      <Region from="342" to="361" loc="I"/>
      <Region from="362" to="384" loc="M"/>
      <Region from="385" to="395" loc="O"/>
      <Region from="396" to="416" loc="M"/>
      <Region from="417" to="516" loc="I"/>
      <Region from="517" to="538" loc="M"/>
      <Region from="539" to="569" loc="O"/>
      <Region from="570" to="588" loc="M"/>
      <Region from="589" to="619" loc="I"/>
      <Region from="620" to="641" loc="M"/>
      <Region from="642" to="680" loc="O"/>
      <Region from="681" to="701" loc="M"/>
      <Region from="702" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="143" loc="I"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="225" loc="O"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="319" loc="I"/>
      <Region from="320" to="340" loc="M"/>
      <Region from="341" to="362" loc="O"/>
      <Region from="363" to="383" loc="M"/>
      <Region from="384" to="394" loc="I"/>
      <Region from="395" to="415" loc="M"/>
      <Region from="416" to="579" loc="O"/>
      <Region from="580" to="600" loc="M"/>
      <Region from="601" to="620" loc="I"/>
      <Region from="621" to="641" loc="M"/>
      <Region from="642" to="680" loc="O"/>
      <Region from="681" to="701" loc="M"/>
      <Region from="702" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="141" loc="I"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="226" loc="O"/>
      <Region from="227" to="247" loc="M"/>
      <Region from="248" to="317" loc="I"/>
      <Region from="318" to="338" loc="M"/>
      <Region from="339" to="363" loc="O"/>
      <Region from="364" to="384" loc="M"/>
      <Region from="385" to="395" loc="I"/>
      <Region from="396" to="416" loc="M"/>
      <Region from="417" to="570" loc="O"/>
      <Region from="571" to="591" loc="M"/>
      <Region from="592" to="620" loc="I"/>
      <Region from="621" to="641" loc="M"/>
      <Region from="642" to="681" loc="O"/>
      <Region from="682" to="702" loc="M"/>
      <Region from="703" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="141" loc="O"/>
      <Region from="142" to="161" loc="M"/>
      <Region from="162" to="194" loc="I"/>
      <Region from="195" to="214" loc="M"/>
      <Region from="215" to="225" loc="O"/>
      <Region from="226" to="245" loc="M"/>
      <Region from="246" to="317" loc="I"/>
      <Region from="318" to="337" loc="M"/>
      <Region from="338" to="396" loc="O"/>
      <Region from="397" to="416" loc="M"/>
      <Region from="417" to="513" loc="I"/>
      <Region from="514" to="533" loc="M"/>
      <Region from="534" to="581" loc="O"/>
      <Region from="582" to="601" loc="M"/>
      <Region from="602" to="619" loc="I"/>
      <Region from="620" to="639" loc="M"/>
      <Region from="640" to="680" loc="O"/>
      <Region from="681" to="701" loc="M"/>
      <Region from="702" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="144" loc="I"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="225" loc="O"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="315" loc="I"/>
      <Region from="316" to="336" loc="M"/>
      <Region from="337" to="361" loc="O"/>
      <Region from="362" to="382" loc="M"/>
      <Region from="383" to="399" loc="I"/>
      <Region from="400" to="420" loc="M"/>
      <Region from="421" to="508" loc="O"/>
      <Region from="509" to="529" loc="M"/>
      <Region from="530" to="561" loc="I"/>
      <Region from="562" to="582" loc="M"/>
      <Region from="583" to="583" loc="O"/>
      <Region from="584" to="604" loc="M"/>
      <Region from="605" to="619" loc="I"/>
      <Region from="620" to="640" loc="M"/>
      <Region from="641" to="684" loc="O"/>
      <Region from="685" to="705" loc="M"/>
      <Region from="706" to="1101" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="142" loc="I"/>
      <Region from="143" to="165" loc="M"/>
      <Region from="166" to="194" loc="O"/>
      <Region from="195" to="214" loc="M"/>
      <Region from="215" to="226" loc="I"/>
      <Region from="227" to="246" loc="M"/>
      <Region from="247" to="319" loc="O"/>
      <Region from="320" to="342" loc="M"/>
      <Region from="343" to="362" loc="I"/>
      <Region from="363" to="382" loc="M"/>
      <Region from="383" to="396" loc="O"/>
      <Region from="397" to="416" loc="M"/>
      <Region from="417" to="511" loc="I"/>
      <Region from="512" to="534" loc="M"/>
      <Region from="535" to="570" loc="O"/>
      <Region from="571" to="593" loc="M"/>
      <Region from="594" to="618" loc="I"/>
      <Region from="619" to="641" loc="M"/>
      <Region from="642" to="678" loc="O"/>
      <Region from="679" to="701" loc="M"/>
      <Region from="702" to="1101" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
