<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H0YKZ9_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Gamma-secretase subunit APH-1 </Name>
  <CrossRef>
    <PDBTM id="8oqz">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5a63">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn2">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn3">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn4">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn5">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6idf">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6iyc">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6lqg">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6lr4">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7c9i">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7d8x">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5t">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5x">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5z">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8im7">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8k8e">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x52">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x53">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x54">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8oqy">
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="APH1A_HUMAN">
      <Alignment>
        <CrossRefSeq>VTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSL</CrossRefSeq>
        <OrigSeq>IIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAP-SMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCL</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="188" CheckSum="ba55b7684452f64a56726d8ea66d68f8">
    <Seq>
      MARVIIDNKD GPTQKYLLIF GAFVSVYIQE MFRFAYYKLL KKASEGLKSI
      NPGETAPSMR LLAYVSGLGF GIMSGVFSFV NTLSDSLGPG TVGIHGDSPQ
      FFLYSAFMTL VIILLHVFWG IVFFDGCEKK KWGILLIVLL THLLVSAQTF
      ISSYYGINLA SAFIILVLMG TWAFLAAGGS CRSLKLCL
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="90.89">
    <Region from="1" to="21" loc="O"/>
    <Region from="22" to="36" loc="M"/>
    <Region from="37" to="62" loc="I"/>
    <Region from="63" to="78" loc="M"/>
    <Region from="79" to="105" loc="O"/>
    <Region from="106" to="123" loc="M"/>
    <Region from="124" to="131" loc="I"/>
    <Region from="132" to="145" loc="M"/>
    <Region from="146" to="158" loc="O"/>
    <Region from="159" to="173" loc="M"/>
    <Region from="174" to="188" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="14" loc="O"/>
      <Region from="15" to="28" loc="M"/>
      <Region from="29" to="62" loc="I"/>
      <Region from="63" to="84" loc="M"/>
      <Region from="85" to="105" loc="O"/>
      <Region from="106" to="124" loc="M"/>
      <Region from="125" to="131" loc="I"/>
      <Region from="132" to="151" loc="M"/>
      <Region from="152" to="158" loc="O"/>
      <Region from="159" to="179" loc="M"/>
      <Region from="180" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="17" loc="O"/>
      <Region from="18" to="33" loc="M"/>
      <Region from="34" to="61" loc="I"/>
      <Region from="62" to="84" loc="M"/>
      <Region from="85" to="100" loc="O"/>
      <Region from="101" to="124" loc="M"/>
      <Region from="125" to="134" loc="I"/>
      <Region from="135" to="150" loc="M"/>
      <Region from="151" to="153" loc="O"/>
      <Region from="154" to="179" loc="M"/>
      <Region from="180" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="60" loc="I"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="87" loc="O"/>
      <Region from="88" to="93" loc="L"/>
      <Region from="94" to="102" loc="O"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="133" loc="I"/>
      <Region from="134" to="154" loc="M"/>
      <Region from="155" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="37" loc="M"/>
      <Region from="38" to="60" loc="I"/>
      <Region from="61" to="80" loc="M"/>
      <Region from="81" to="100" loc="O"/>
      <Region from="101" to="123" loc="M"/>
      <Region from="124" to="131" loc="I"/>
      <Region from="132" to="151" loc="M"/>
      <Region from="152" to="158" loc="O"/>
      <Region from="159" to="181" loc="M"/>
      <Region from="182" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="40" loc="M"/>
      <Region from="41" to="60" loc="I"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="100" loc="O"/>
      <Region from="101" to="125" loc="M"/>
      <Region from="126" to="131" loc="I"/>
      <Region from="132" to="151" loc="M"/>
      <Region from="152" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="63" loc="I"/>
      <Region from="64" to="84" loc="M"/>
      <Region from="85" to="99" loc="O"/>
      <Region from="100" to="120" loc="M"/>
      <Region from="121" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="37" loc="M"/>
      <Region from="38" to="63" loc="I"/>
      <Region from="64" to="84" loc="M"/>
      <Region from="85" to="100" loc="O"/>
      <Region from="101" to="122" loc="M"/>
      <Region from="123" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="35" loc="M"/>
      <Region from="36" to="59" loc="I"/>
      <Region from="60" to="79" loc="M"/>
      <Region from="80" to="100" loc="O"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="131" loc="I"/>
      <Region from="132" to="151" loc="M"/>
      <Region from="152" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="60" loc="I"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="100" loc="O"/>
      <Region from="101" to="121" loc="M"/>
      <Region from="122" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="156" loc="O"/>
      <Region from="157" to="177" loc="M"/>
      <Region from="178" to="188" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="14" loc="O"/>
      <Region from="15" to="37" loc="M"/>
      <Region from="38" to="57" loc="I"/>
      <Region from="58" to="80" loc="M"/>
      <Region from="81" to="99" loc="O"/>
      <Region from="100" to="122" loc="M"/>
      <Region from="123" to="134" loc="I"/>
      <Region from="135" to="157" loc="M"/>
      <Region from="158" to="161" loc="O"/>
      <Region from="162" to="184" loc="M"/>
      <Region from="185" to="188" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
