<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H3BN68_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>ENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKK-------------------WFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLA--QYSVLFYGYYDN---KRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEER--AAQVEENIHLIRFLRFLANFFVFL-TLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVL-YMIVSLPPSFDCGPFSGK----NRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLN-ATAKGQKAANLDLKKKMKQQALENKMRNKKM</CrossRefSeq>
        <OrigSeq>TSRDRIKAIRNQPRTMEEKRNLSRGGLTITTEDEGRAKAHLTWWKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKK---------------NTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSN---PGAVLLLPFVVSCINLAVPCIYSMFRLVERYE------MPRHEVYVLLIRNIFLKISII----------------GILCY-----------------------YWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLR----RIIGMQLITSLGLQ-----EFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>SQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTL-PVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSL-----SPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVSSDDDSQHNRSTAKSV</CrossRefSeq>
        <OrigSeq>LSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLR----RIIGMQLIT-----SLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="689" CheckSum="17e900dd5e7b180e7e307a985b786efd">
    <Seq>
      MLSDDHVNEI IIQKLIASLI PMTSRDRIKA IRNQPRTMEE KRNLSRGGLT
      ITTEDEGRAK AHLTWWKIVD KEKSKQTHRI LQLNCCIQCL NSISRAYRRS
      KNSLSEILNS ISLWQKTLKI IGGKFGTSVL SYFNFLRWLL KFNIFSFILN
      FSFIIIPQFT VAKKNTLQFT GLEFFTGVGY FRDTVMYYGF YTNSTIQHGN
      SGASYNMQLA YIFTIGACLT TCFFSLLFSM AKYFRNNFIN PHIYSGGITK
      LIFCWDFTVT HEKAVKLKQK NLSTEIRENL SELRQENSKL TFNQLLTRFS
      AYMVAWVVST GVAIACCAAV YYLAEYNLEF LKTHSNPGAV LLLPFVVSCI
      NLAVPCIYSM FRLVERYEMP RHEVYVLLIR NIFLKISIIG ILCYYWLNTV
      ALSGEECWET LIGQDIYRLL LMDFVFSLVN SFLGEFLRRI IGMQLITSLG
      LQEFDIARNV LELIYAQTLV WIGIFFCPLL PFIQMIMLFI MFYSKNISLM
      MNFQPPSKAW RASQMMTFFI FLLFFPSFTG VLCTLAITIW RLKPSADCGP
      FRGLPLFIHS IYSWIDTLST RPGYLWVVWI YRNLIGSVHF FFILTLIVLI
      ITYLYWQITE GRKIMIRLLH EQIINEGKDK MFLIEKLIKL QDMEKKANPS
      SLVLERREVE QQGFLHLGEH DGSLDLRSRR SVQEGNPRA
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="86.24">
    <Region from="1" to="137" loc="I"/>
    <Region from="138" to="156" loc="M"/>
    <Region from="157" to="207" loc="O"/>
    <Region from="208" to="228" loc="M"/>
    <Region from="229" to="298" loc="I"/>
    <Region from="299" to="320" loc="M"/>
    <Region from="321" to="337" loc="O"/>
    <Region from="338" to="357" loc="M"/>
    <Region from="358" to="375" loc="I"/>
    <Region from="376" to="397" loc="M"/>
    <Region from="398" to="468" loc="O"/>
    <Region from="469" to="492" loc="M"/>
    <Region from="493" to="515" loc="I"/>
    <Region from="516" to="537" loc="M"/>
    <Region from="538" to="583" loc="O"/>
    <Region from="584" to="605" loc="M"/>
    <Region from="606" to="689" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="143" loc="I"/>
      <Region from="144" to="162" loc="M"/>
      <Region from="163" to="208" loc="O"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="300" loc="I"/>
      <Region from="301" to="321" loc="M"/>
      <Region from="322" to="337" loc="O"/>
      <Region from="338" to="355" loc="M"/>
      <Region from="356" to="385" loc="I"/>
      <Region from="386" to="404" loc="M"/>
      <Region from="405" to="468" loc="O"/>
      <Region from="469" to="490" loc="M"/>
      <Region from="491" to="517" loc="I"/>
      <Region from="518" to="539" loc="M"/>
      <Region from="540" to="583" loc="O"/>
      <Region from="584" to="604" loc="M"/>
      <Region from="605" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="128" loc="I"/>
      <Region from="129" to="157" loc="M"/>
      <Region from="158" to="206" loc="O"/>
      <Region from="207" to="230" loc="M"/>
      <Region from="231" to="298" loc="I"/>
      <Region from="299" to="324" loc="M"/>
      <Region from="325" to="340" loc="O"/>
      <Region from="341" to="359" loc="M"/>
      <Region from="360" to="375" loc="I"/>
      <Region from="376" to="397" loc="M"/>
      <Region from="398" to="417" loc="O"/>
      <Region from="418" to="442" loc="M"/>
      <Region from="443" to="461" loc="I"/>
      <Region from="462" to="483" loc="M"/>
      <Region from="484" to="486" loc="O"/>
      <Region from="487" to="502" loc="M"/>
      <Region from="503" to="516" loc="I"/>
      <Region from="517" to="540" loc="M"/>
      <Region from="541" to="582" loc="O"/>
      <Region from="583" to="607" loc="M"/>
      <Region from="608" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="125" loc="O"/>
      <Region from="126" to="156" loc="M"/>
      <Region from="157" to="168" loc="I"/>
      <Region from="169" to="189" loc="M"/>
      <Region from="190" to="205" loc="O"/>
      <Region from="206" to="226" loc="M"/>
      <Region from="227" to="295" loc="I"/>
      <Region from="296" to="326" loc="M"/>
      <Region from="327" to="338" loc="O"/>
      <Region from="339" to="359" loc="M"/>
      <Region from="360" to="368" loc="I"/>
      <Region from="369" to="399" loc="M"/>
      <Region from="400" to="418" loc="O"/>
      <Region from="419" to="439" loc="M"/>
      <Region from="440" to="461" loc="I"/>
      <Region from="462" to="476" loc="M"/>
      <Region from="477" to="477" loc="O"/>
      <Region from="478" to="492" loc="M"/>
      <Region from="493" to="508" loc="I"/>
      <Region from="509" to="539" loc="M"/>
      <Region from="540" to="577" loc="O"/>
      <Region from="578" to="608" loc="M"/>
      <Region from="609" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="161" loc="M"/>
      <Region from="162" to="208" loc="O"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="301" loc="I"/>
      <Region from="302" to="324" loc="M"/>
      <Region from="325" to="339" loc="O"/>
      <Region from="340" to="361" loc="M"/>
      <Region from="362" to="376" loc="I"/>
      <Region from="377" to="398" loc="M"/>
      <Region from="399" to="415" loc="O"/>
      <Region from="416" to="437" loc="M"/>
      <Region from="438" to="467" loc="I"/>
      <Region from="468" to="493" loc="M"/>
      <Region from="494" to="516" loc="O"/>
      <Region from="517" to="540" loc="M"/>
      <Region from="541" to="547" loc="I"/>
      <Region from="548" to="568" loc="M"/>
      <Region from="569" to="584" loc="O"/>
      <Region from="585" to="607" loc="M"/>
      <Region from="608" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="137" loc="I"/>
      <Region from="138" to="159" loc="M"/>
      <Region from="160" to="208" loc="O"/>
      <Region from="209" to="228" loc="M"/>
      <Region from="229" to="298" loc="I"/>
      <Region from="299" to="324" loc="M"/>
      <Region from="325" to="338" loc="O"/>
      <Region from="339" to="361" loc="M"/>
      <Region from="362" to="372" loc="I"/>
      <Region from="373" to="397" loc="M"/>
      <Region from="398" to="416" loc="O"/>
      <Region from="417" to="437" loc="M"/>
      <Region from="438" to="467" loc="I"/>
      <Region from="468" to="493" loc="M"/>
      <Region from="494" to="512" loc="O"/>
      <Region from="513" to="537" loc="M"/>
      <Region from="538" to="548" loc="I"/>
      <Region from="549" to="565" loc="M"/>
      <Region from="566" to="584" loc="O"/>
      <Region from="585" to="606" loc="M"/>
      <Region from="607" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="141" loc="I"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="210" loc="O"/>
      <Region from="211" to="231" loc="M"/>
      <Region from="232" to="303" loc="I"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="339" loc="O"/>
      <Region from="340" to="360" loc="M"/>
      <Region from="361" to="380" loc="I"/>
      <Region from="381" to="401" loc="M"/>
      <Region from="402" to="473" loc="O"/>
      <Region from="474" to="494" loc="M"/>
      <Region from="495" to="514" loc="I"/>
      <Region from="515" to="535" loc="M"/>
      <Region from="536" to="583" loc="O"/>
      <Region from="584" to="604" loc="M"/>
      <Region from="605" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="141" loc="I"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="207" loc="O"/>
      <Region from="208" to="228" loc="M"/>
      <Region from="229" to="303" loc="I"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="340" loc="O"/>
      <Region from="341" to="361" loc="M"/>
      <Region from="362" to="376" loc="I"/>
      <Region from="377" to="397" loc="M"/>
      <Region from="398" to="474" loc="O"/>
      <Region from="475" to="495" loc="M"/>
      <Region from="496" to="515" loc="I"/>
      <Region from="516" to="536" loc="M"/>
      <Region from="537" to="587" loc="O"/>
      <Region from="588" to="608" loc="M"/>
      <Region from="609" to="689" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="134" loc="I"/>
      <Region from="135" to="155" loc="M"/>
      <Region from="156" to="208" loc="O"/>
      <Region from="209" to="228" loc="M"/>
      <Region from="229" to="300" loc="I"/>
      <Region from="301" to="320" loc="M"/>
      <Region from="321" to="337" loc="O"/>
      <Region from="338" to="357" loc="M"/>
      <Region from="358" to="381" loc="I"/>
      <Region from="382" to="401" loc="M"/>
      <Region from="402" to="416" loc="O"/>
      <Region from="417" to="436" loc="M"/>
      <Region from="437" to="456" loc="I"/>
      <Region from="457" to="476" loc="M"/>
      <Region from="477" to="478" loc="O"/>
      <Region from="479" to="498" loc="M"/>
      <Region from="499" to="514" loc="I"/>
      <Region from="515" to="534" loc="M"/>
      <Region from="535" to="587" loc="O"/>
      <Region from="588" to="608" loc="M"/>
      <Region from="609" to="689" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="134" loc="I"/>
      <Region from="135" to="155" loc="M"/>
      <Region from="156" to="206" loc="O"/>
      <Region from="207" to="227" loc="M"/>
      <Region from="228" to="295" loc="I"/>
      <Region from="296" to="316" loc="M"/>
      <Region from="317" to="337" loc="O"/>
      <Region from="338" to="358" loc="M"/>
      <Region from="359" to="376" loc="I"/>
      <Region from="377" to="397" loc="M"/>
      <Region from="398" to="415" loc="O"/>
      <Region from="416" to="436" loc="M"/>
      <Region from="437" to="459" loc="I"/>
      <Region from="460" to="480" loc="M"/>
      <Region from="481" to="481" loc="O"/>
      <Region from="482" to="502" loc="M"/>
      <Region from="503" to="516" loc="I"/>
      <Region from="517" to="537" loc="M"/>
      <Region from="538" to="588" loc="O"/>
      <Region from="589" to="609" loc="M"/>
      <Region from="610" to="689" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="161" loc="M"/>
      <Region from="162" to="206" loc="O"/>
      <Region from="207" to="229" loc="M"/>
      <Region from="230" to="301" loc="I"/>
      <Region from="302" to="324" loc="M"/>
      <Region from="325" to="338" loc="O"/>
      <Region from="339" to="361" loc="M"/>
      <Region from="362" to="373" loc="I"/>
      <Region from="374" to="396" loc="M"/>
      <Region from="397" to="469" loc="O"/>
      <Region from="470" to="492" loc="M"/>
      <Region from="493" to="517" loc="I"/>
      <Region from="518" to="540" loc="M"/>
      <Region from="541" to="583" loc="O"/>
      <Region from="584" to="606" loc="M"/>
      <Region from="607" to="689" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
