<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H3BNW8_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>RQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPR------------AEEASAANFGVLYDF---NGLAQYSVLFYGYYDNK-RTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTF-NFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEER-----AAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEM----NMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYC---WCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKM</CrossRefSeq>
        <OrigSeq>NLSSHSLRNYALNISEK-RRLRDIQETQMKYLSE--------WDQWKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPVLLTKYKITNSSFVLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNFTYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERMRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLFILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSCDDDT------------CDLCGYNQK---------------------LYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQ-------EFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTVS-TFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLVRKHSSRGSWLG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>ASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLN---LYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVS</CrossRefSeq>
        <OrigSeq>TSCDDDTCDLCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQ-------EFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTV-STFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLVRKHSSRGS-WLGTFTQDTARKVLFSWEGVKLLQPSLTTTSP</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="758" CheckSum="7fdb7b7911e5bf90a43e299579b1b0f8">
    <Seq>
      MSESSGSALQ PGRPSRQPAV HPENLSLDSS CFSSPPVNFL QELPSYRSIA
      RRRTTVHSRD KQSGTLLKPT DSYSSQLEDR IAENLSSHSL RNYALNISEK
      RRLRDIQETQ MKYLSEWDQW KRYSSKSWKR FLEKAREMTT HLELWREDIR
      SIEGKFGTGI QSYFSFLRFL VLLNLVIFLI IFMLVLLPVL LTKYKITNSS
      FVLIPFKDMD KQCTVYPVSS SGLIYFYSYI IDLLSGTGFL EETSLFYGHY
      TIDGVKFQNF TYDLPLAYLL STIASLALSL LWIVKRSVEG FKINLIRSEE
      HFQSYCNKIF AGWDFCITNR SMADLKHSSL RYELRADLEE ERMRQKIAER
      TSEETIRIYS LRLFLNCIVL AVLGACFYAI YVATVFSQEH MKKEIDKMVF
      GENLFILYLP SIVITLANFI TPMIFAKIIR YEDYSPGFEI RLTILRCVFM
      RLATICVLVF TLGSKITSCD DDTCDLCGYN QKLYPCWETQ VGQEMYKLMI
      FDFIIILAVT LFVDFPRKLL VTYCSSCKLI QCWGQQEFAI PDNVLGIVYG
      QTICWIGAFF SPLLPAIATL KFIIIFYVKE WSLLYTCRPS PRPFRASNSN
      FFFLLVLLIG LCLAIIPLTI SISRIPSSKA CGPFTNFNTT WEVIPKTVST
      FPSSLQSFIH GVTSEAFAVP FFMIICLIMF YFIALAGAHK RVVIQLREQL
      SLVRKHSSRG SWLGTFTQDT ARKVLFSWEG VKLLQPSLTT TSPKLCLEAQ
      PRPASLIH
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="81.42">
    <Region from="1" to="165" loc="I"/>
    <Region from="166" to="187" loc="M"/>
    <Region from="188" to="263" loc="O"/>
    <Region from="264" to="283" loc="M"/>
    <Region from="284" to="360" loc="I"/>
    <Region from="361" to="382" loc="M"/>
    <Region from="383" to="403" loc="O"/>
    <Region from="404" to="425" loc="M"/>
    <Region from="426" to="446" loc="I"/>
    <Region from="447" to="462" loc="M"/>
    <Region from="463" to="551" loc="O"/>
    <Region from="552" to="578" loc="M"/>
    <Region from="579" to="599" loc="I"/>
    <Region from="600" to="620" loc="M"/>
    <Region from="621" to="665" loc="O"/>
    <Region from="666" to="685" loc="M"/>
    <Region from="686" to="758" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="169" loc="I"/>
      <Region from="170" to="191" loc="M"/>
      <Region from="192" to="265" loc="O"/>
      <Region from="266" to="284" loc="M"/>
      <Region from="285" to="362" loc="I"/>
      <Region from="363" to="386" loc="M"/>
      <Region from="387" to="552" loc="O"/>
      <Region from="553" to="578" loc="M"/>
      <Region from="579" to="600" loc="I"/>
      <Region from="601" to="625" loc="M"/>
      <Region from="626" to="665" loc="O"/>
      <Region from="666" to="688" loc="M"/>
      <Region from="689" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="159" loc="I"/>
      <Region from="160" to="190" loc="M"/>
      <Region from="191" to="262" loc="O"/>
      <Region from="263" to="285" loc="M"/>
      <Region from="286" to="359" loc="I"/>
      <Region from="360" to="384" loc="M"/>
      <Region from="385" to="407" loc="O"/>
      <Region from="408" to="426" loc="M"/>
      <Region from="427" to="441" loc="I"/>
      <Region from="442" to="463" loc="M"/>
      <Region from="464" to="495" loc="O"/>
      <Region from="496" to="523" loc="M"/>
      <Region from="524" to="545" loc="I"/>
      <Region from="546" to="567" loc="M"/>
      <Region from="568" to="570" loc="O"/>
      <Region from="571" to="586" loc="M"/>
      <Region from="587" to="600" loc="I"/>
      <Region from="601" to="623" loc="M"/>
      <Region from="624" to="660" loc="O"/>
      <Region from="661" to="685" loc="M"/>
      <Region from="686" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="157" loc="I"/>
      <Region from="158" to="172" loc="M"/>
      <Region from="173" to="173" loc="O"/>
      <Region from="174" to="188" loc="M"/>
      <Region from="189" to="218" loc="I"/>
      <Region from="219" to="249" loc="M"/>
      <Region from="250" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="354" loc="I"/>
      <Region from="355" to="385" loc="M"/>
      <Region from="386" to="405" loc="O"/>
      <Region from="406" to="426" loc="M"/>
      <Region from="427" to="440" loc="I"/>
      <Region from="441" to="461" loc="M"/>
      <Region from="462" to="498" loc="O"/>
      <Region from="499" to="519" loc="M"/>
      <Region from="520" to="545" loc="I"/>
      <Region from="546" to="560" loc="M"/>
      <Region from="561" to="561" loc="O"/>
      <Region from="562" to="576" loc="M"/>
      <Region from="577" to="598" loc="I"/>
      <Region from="599" to="619" loc="M"/>
      <Region from="620" to="663" loc="O"/>
      <Region from="664" to="684" loc="M"/>
      <Region from="685" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="169" loc="O"/>
      <Region from="170" to="192" loc="M"/>
      <Region from="193" to="212" loc="I"/>
      <Region from="213" to="231" loc="M"/>
      <Region from="232" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="362" loc="I"/>
      <Region from="363" to="382" loc="M"/>
      <Region from="383" to="404" loc="O"/>
      <Region from="405" to="426" loc="M"/>
      <Region from="427" to="446" loc="I"/>
      <Region from="447" to="463" loc="M"/>
      <Region from="464" to="552" loc="O"/>
      <Region from="553" to="578" loc="M"/>
      <Region from="579" to="598" loc="I"/>
      <Region from="599" to="620" loc="M"/>
      <Region from="621" to="665" loc="O"/>
      <Region from="666" to="687" loc="M"/>
      <Region from="688" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="168" loc="O"/>
      <Region from="169" to="192" loc="M"/>
      <Region from="193" to="212" loc="I"/>
      <Region from="213" to="231" loc="M"/>
      <Region from="232" to="265" loc="O"/>
      <Region from="266" to="284" loc="M"/>
      <Region from="285" to="362" loc="I"/>
      <Region from="363" to="384" loc="M"/>
      <Region from="385" to="403" loc="O"/>
      <Region from="404" to="425" loc="M"/>
      <Region from="426" to="494" loc="I"/>
      <Region from="495" to="513" loc="M"/>
      <Region from="514" to="554" loc="O"/>
      <Region from="555" to="578" loc="M"/>
      <Region from="579" to="598" loc="I"/>
      <Region from="599" to="620" loc="M"/>
      <Region from="621" to="666" loc="O"/>
      <Region from="667" to="688" loc="M"/>
      <Region from="689" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="168" loc="I"/>
      <Region from="169" to="189" loc="M"/>
      <Region from="190" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="362" loc="I"/>
      <Region from="363" to="383" loc="M"/>
      <Region from="384" to="403" loc="O"/>
      <Region from="404" to="424" loc="M"/>
      <Region from="425" to="439" loc="I"/>
      <Region from="440" to="460" loc="M"/>
      <Region from="461" to="557" loc="O"/>
      <Region from="558" to="578" loc="M"/>
      <Region from="579" to="598" loc="I"/>
      <Region from="599" to="619" loc="M"/>
      <Region from="620" to="665" loc="O"/>
      <Region from="666" to="686" loc="M"/>
      <Region from="687" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="165" loc="I"/>
      <Region from="166" to="186" loc="M"/>
      <Region from="187" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="357" loc="I"/>
      <Region from="358" to="378" loc="M"/>
      <Region from="379" to="407" loc="O"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="439" loc="I"/>
      <Region from="440" to="460" loc="M"/>
      <Region from="461" to="558" loc="O"/>
      <Region from="559" to="579" loc="M"/>
      <Region from="580" to="599" loc="I"/>
      <Region from="600" to="620" loc="M"/>
      <Region from="621" to="665" loc="O"/>
      <Region from="666" to="686" loc="M"/>
      <Region from="687" to="758" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="161" loc="I"/>
      <Region from="162" to="182" loc="M"/>
      <Region from="183" to="263" loc="O"/>
      <Region from="264" to="283" loc="M"/>
      <Region from="284" to="357" loc="I"/>
      <Region from="358" to="377" loc="M"/>
      <Region from="378" to="403" loc="O"/>
      <Region from="404" to="423" loc="M"/>
      <Region from="424" to="446" loc="I"/>
      <Region from="447" to="466" loc="M"/>
      <Region from="467" to="495" loc="O"/>
      <Region from="496" to="515" loc="M"/>
      <Region from="516" to="543" loc="I"/>
      <Region from="544" to="563" loc="M"/>
      <Region from="564" to="565" loc="O"/>
      <Region from="566" to="585" loc="M"/>
      <Region from="586" to="600" loc="I"/>
      <Region from="601" to="620" loc="M"/>
      <Region from="621" to="665" loc="O"/>
      <Region from="666" to="686" loc="M"/>
      <Region from="687" to="758" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="166" loc="I"/>
      <Region from="167" to="187" loc="M"/>
      <Region from="188" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="355" loc="I"/>
      <Region from="356" to="376" loc="M"/>
      <Region from="377" to="404" loc="O"/>
      <Region from="405" to="425" loc="M"/>
      <Region from="426" to="446" loc="I"/>
      <Region from="447" to="467" loc="M"/>
      <Region from="468" to="495" loc="O"/>
      <Region from="496" to="516" loc="M"/>
      <Region from="517" to="543" loc="I"/>
      <Region from="544" to="564" loc="M"/>
      <Region from="565" to="565" loc="O"/>
      <Region from="566" to="586" loc="M"/>
      <Region from="587" to="601" loc="I"/>
      <Region from="602" to="622" loc="M"/>
      <Region from="623" to="665" loc="O"/>
      <Region from="666" to="686" loc="M"/>
      <Region from="687" to="758" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="168" loc="O"/>
      <Region from="169" to="191" loc="M"/>
      <Region from="192" to="217" loc="I"/>
      <Region from="218" to="240" loc="M"/>
      <Region from="241" to="259" loc="O"/>
      <Region from="260" to="282" loc="M"/>
      <Region from="283" to="362" loc="I"/>
      <Region from="363" to="385" loc="M"/>
      <Region from="386" to="397" loc="O"/>
      <Region from="398" to="420" loc="M"/>
      <Region from="421" to="497" loc="I"/>
      <Region from="498" to="515" loc="M"/>
      <Region from="516" to="555" loc="O"/>
      <Region from="556" to="578" loc="M"/>
      <Region from="579" to="598" loc="I"/>
      <Region from="599" to="621" loc="M"/>
      <Region from="622" to="665" loc="O"/>
      <Region from="666" to="688" loc="M"/>
      <Region from="689" to="758" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
