Extended synaptotagmin 2 LRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPS---------------------GKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT MSGARGEGPEAGAGGAGG--------RAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT GGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVARWYDLMDNKDK ASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTR GMLVVIVHSAEDVEGKH---------HTNPYVRIYFKGEERKTKHVKKNRDPRWNEEFTFMLEEPPVREKLHVEVLSTSSRIGLLHPKETLGYVDIPVVDVVNNKRMNQKFHLIDSKNGKIQIELEW GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQ-ELEIELFDEDPD-----KDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEW SLQLNIPQLLSGSNLSIGILEITVKNAKGLKRTSSILNESIDPY----LSFEFNDISIAKTRTVRDTLNPVWDETLYVLLNSF---TDPLTISVYDKRAKLKDK--VLGRIQYNLNTL QSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSE---DGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASE SKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFVG--SNATGTELRHWSDMLANPRRPIA PTPSIASDISLPIATQELRQR---LRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA SKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFVG--SNATGTELRHWSDMLANPRRPIA PTPSIASDISLPIATQELRQR---LRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA SKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA--IGKVFVGYNS--TGAELRHWSDMLANPRRPIA PTPSIASDISLPIATQELRQ---RLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA SKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA--IGKVFVGYNS--TGAELRHWSDMLANPRRPIA PTPSIASDISLPIATQELRQ---RLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA SKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDA--IGKVFVGYNS--TGAELRHWSDMLANPRRPIA PTPSIASDISLPIATQELRQ---RLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQA GRIQFSVGYNFQESTLTVKIMKAQELPAKDF------SGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNP--------------------------SANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRV-----------------EKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQ EVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENLSPKWNEVYEAL---VYEHPGQELEIELFDED-PDKDDFLGSLMIDLIEVEKERLLDEWFTLDEV-----PKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHN--PKRQDLEVEVRDEQ---HQCSLGNLKV----------PLSQLLTSEDMTVSQRFQ PPEPSYLDMDSYPEAAVASVVAAGVKPSQTSPELPSEGGTGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTTQADPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRTGGGSGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHD--LIGQVVLDNLLELAEQPPDRPLWRDILEGGSEKADL LHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISL---------PIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVA--LASEELAKGWTQWYDLTEDGTRPQAM GRIQFSVGYNFQESTLTVKVMKAQELPAKDF------SGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRVLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNP--------------------------SANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKK-----------------RNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQ EVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENLSPKWNEVYEAL---VYEHPGQELEIELFDED-PDKDDFLGSLMIDLIEVEKERLLDEWFTLDEV-----PKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHN--PKRQDLEVEVRDEQ---HQCSLGNLKV----------PLSQLLTSEDMTVSQRFQ GRIQFSVGYNFQESTLTVKVMKAQELPAKDF------SGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNP--------------------------SANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKK-----------------RNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQ EVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV---GNQIFQSRVIKENLSPKWNEVYEAL---VYEHPGQELEIELFDED-PDKDDFLGSLMIDLIEVEKERLLDEWFTLDEV-----PKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHN--PKRQDLEVEVRDEQ---HQCSLGNLKV----------PLSQLLTSEDMTVSQRFQ LQNSLKDVKDVGILQVKVLKAADLLAADF------SGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPN--CYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQW QIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEVEKERLLDEWFTLDEVP-----KG--KLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSS---ALLILYLDSARNLPSNPLEFNPD SYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRR--RYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDA--IGEVRVPMSSVDLGRPVQAWRELQAAPRE SDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGS-DPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTR WICCQRKSSKSNKTPPYKFVHVLKGVDIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGLPAMDEQSMTSDPYIKMTILPEKKH--KVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHFTILSFDRFSRDD--IIGEVLIPLSGIELSEG AQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSP--LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG--SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKG WICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEKRDLNGNFPKTNPKAGSSSDLENVTPKLFPETEKEAVSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKH--KVKTRVLRKTLDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDD--VIGEVLVPLSGIELSDG AQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSP--LGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDG--SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKG VPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENI----------DPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDL--------VDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDG VPLVSEVQIAQLRFPVPKGVLR-------IHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHP----GQELEIELFDEDPDKDDFLGSLMIDLIEV---EKERLLDEWFTLDE------VPKGKLHLRLEWLT------LMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTF-FIHNPKRQDLEVEVRDEQH--QCSLGNLKVPLSQLLTSEDM LRVFILYAENVHTPDTDISDAYCSAVFAGV-----KKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNR--FLGEAKVPLREVLATPSLSASFNAPLLDTKKQP LIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEV-QRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWY--DLTEDGTRP LRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTK-----KVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQNK--LIGTATVALKDLTGDQSRSLPYKLIS LIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQ-RRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTE MSGARGEGPE AGAGGAGGRA APENPGGVLS VELPGLLAQL ARSFALLLPV YALGYLGLSF SWVLLALALL AWCRRSRGLK ALRLCRALAL LEDEERVVRL GVRACDLPAW VHFPDTERAE WLNKTVKHMW PFICQFIEKL FRETIEPAVR GANTHLSTFS FTKVDVGQQP LRINGVKVYT ENVDKRQIIL DLQISFVGNC EIDLEIKRYF CRAGVKSIQI HGTMRVILEP LIGDMPLVGA LSIFFLRKPL LEINWTGLTN LLDVPGLNGL SDTIILDIIS NYLVLPNRIT VPLVSEVQIA QLRFPVPKGV LRIHFIEAQD LQGKDTYLKG LVKGKSDPYG IIRVGNQIFQ SRVIKENLSP KWNEVYEALV YEHPGQELEI ELFDEDPDKD DFLGSLMIDL IEVEKERLLD EWFTLDEVPK GKLHLRLEWL TLMPNASNLD KVLTDIKADK DQANDGLSSA LLILYLDSAR NLPSNPLEFN PDVLKKTAVQ RALKSGKKIS SNPNPVVQMS VGHKAQESKI RYKTNEPVWE ENFTFFIHNP KRQDLEVEVR DEQHQCSLGN LKVPLSQLLT SEDMTVSQRF QLSNSGPNST IKMKIALRVL HLEKRERPPD HQHSAQVKRP SVSKEGRKTS IKSHMSGSPG PGGSNTAPST PVIGGSDKPG MEEKAQPPEA GPQGLHDLGR SSSSLLASPG HISVKEPTPS IASDISLPIA TQELRQRLRQ LENGTTLGQS PLGQIQLTIR HSSQRNKLIV VVHACRNLIA FSEDGSDPYV RMYLLPDKRR SGRRKTHVSK KTLNPVFDQS FDFSVSLPEV QRRTLDVAVK NSGGFLSKDK GLLGKVLVAL ASEELAKGWT QWYDLTEDGT RPQAMT