<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H7BXN9_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Organic anion transporter 3 </Name>
  <CrossRef>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jts">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zha">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ju0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jty">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ja4">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ja3">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4qiq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6m2l">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6rw3">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6m20">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8yf0">
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQ</CrossRefSeq>
        <OrigSeq>MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG-----PWVLPMGPNGKPERCLRFVHPPNASLP-----NDTQRAMEPCLDGWVYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRSGPRAF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPLDKQGRPESCLRFPFPHNGT-EANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQDLKSRSR</CrossRefSeq>
        <OrigSeq>MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG-----PWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A2_RABIT">
      <Alignment>
        <CrossRefSeq>TVDDILEQVGHFHFFQKQTFFLLALISAAFTPIYVGIVFLGFTPDHRCRSPGVAELSQRCGWSPGEELNYTVPGLGAADGAFARQCMRYEVDWNQSSPGCVDPLASLAPNRSHLPLGPCQHGWVYDTPGSSIVTEFNLVCARSWMLDLFQSAVNIGFFIGSVGIGYLADRFGRKLCLLVTILINAAAGVLMAVSPNYTWMLIFRLIQGLVSKAGWLIGYILITEFVGLNYRRTVGILYQVAFTVGLLVLAGVAYALPRWRWLQLTVTLPYFCFLLYYWCIPESPRWLISQNKNAKAMRIMEHIAKKNGKSLP------VSLQSLRAAEDVGEKLNPSFLDLVRTPQIRKHTCILMYNWFTSSVLYQGLIMHLGLAGGDIYLDFFYSALVEFPAAFLIIATIDRVGRRYPWAVSNMVAGAACLASVFVPDDLQGLRITVACLGRMGITMAYEMVCLVNAELYPTFIRNLGVLVCSSLCDVGGIVTPFLVYRLTAIWLQLPLVVFAVVGLVAGGLVLMLPETKGRTLPETIEEAENLQRPRKNREKVIYVHVRKA</CrossRefSeq>
        <OrigSeq>TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG-----------PWVLPMGPNGK---PERCLRF-----------VHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRSG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCTN2_HUMAN">
      <Alignment>
        <CrossRefSeq>DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEL----QDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQER</CrossRefSeq>
        <OrigSeq>TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVL-------PMGPNGKPERCLRFVHPPNASLPNDTQRA----------MEPCLDGWVY--NSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA-LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRSGPRA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORCT_DROME">
      <Alignment>
        <CrossRefSeq>MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPEN---ERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQE</CrossRefSeq>
        <OrigSeq>MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP----HNASTGP--WVLPMGPNGKPERCLRFVHPP-----NASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLS---LEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVR--RPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN</CrossRefSeq>
        <OrigSeq>MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNAST-------GPWVLPMGPNGKPERCLRFVHPPNASLPNDTQ-----------RAMEPCLDGWVYNST----KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRSG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22AB_HUMAN">
      <Alignment>
        <CrossRefSeq>MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEA-KNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTS</CrossRefSeq>
        <OrigSeq>MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP------------WVLPMGPNGKPERCLRFVHPPN------ASLPNDTQRAMEPCLDGWVYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAA-LFLPETLNQPLPETIEDLENWSVTASGPISAPPWGSRSGP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCT1_CAEEL">
      <Alignment>
        <CrossRefSeq>DFDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHTCHIP---EGKEYLRPLTNDTQILSCKQYNETQINVFRAFTSAPVDTYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNGKSNVDVDELVDSMKNHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLPETLGAPLPMTIEDAENFGKKPEPDSGMFTQAAKKRESQPLLEP</CrossRefSeq>
        <OrigSeq>TFSEILDRVGSMGHFQFLHVAILGLP-ILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQR---------AMEPCLDGWVYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNL-QKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSVTASGPI---SAPPWGSRSGPRAFP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YDJE_ECOLI">
      <Alignment>
        <CrossRefSeq>SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAECQLREVEQ----QIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRR-TLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASA-----VYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISE</CrossRefSeq>
        <OrigSeq>NSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIP---QWRWLQLTVSIPFFV-FFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYIL---QIIFGGVDVPAK----FITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQT------VRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPL--VKITGEVQPFIPNIIYGITALLGGSA-ALFLPETLNQPLPETIE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YGCS_ECOLI">
      <Alignment>
        <CrossRefSeq>FMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYF---------------GPHVLLGDEVVTATHKH-IKTLFSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALT---ASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAA-TLVVMACLPSG-SSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLWAPETKALPL</CrossRefSeq>
        <OrigSeq>KLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAI-----PQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTF------CLSLAWFA--TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMV-SPLVKITGEVQPFIPNIIYGITALLGGSAALFL--PETLNQPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2A_HUMAN">
      <Alignment>
        <CrossRefSeq>VTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSE--SAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL</CrossRefSeq>
        <OrigSeq>AMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVS-PLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_HUMAN">
      <Alignment>
        <CrossRefSeq>IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE--SMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVL</CrossRefSeq>
        <OrigSeq>LYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVK-ITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_RAT">
      <Alignment>
        <CrossRefSeq>IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE--SMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVL</CrossRefSeq>
        <OrigSeq>LYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVK-ITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MAL11_YEASC">
      <Alignment>
        <CrossRefSeq>SQWQIGLNM-CVLCGEMIGLQITTYMVEFMGNRYTMITALGLLTAYIFILYYCKSLAMIAVGQILSAIPWGCFQSLAVTYASEVCPLALRYYMTSYSNICWLFGQIFASGIMKNSQENLGNSDLGYKLPFALQWIW--------PAPLMIGIFFAPESPWWLVRKDRVAEARKSLSRILSGKGAEKDIQVDLTLKQIELTIEKERLLASKSGSFFNCFK-GVNGRRTRLACLTWVAQNSSGAVLLGYSTYFFERAGMATDKAFTFSLIQYCLG---LAGTLCSWVISGRVGRWTILTYGLAFQMVCLFIIGGMGFGSGSSASNGAGGLLLALSFFYNAGIGA---VVYCIVAEIPSAELRTKTIVLARICYNLMAVINAILTPYMLNVSDWNWGAKTGLYWGGFTAVTLAWVIIDLPETTGRTFSE-INELFNQGVPARK</CrossRefSeq>
        <OrigSeq>SNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPG-------------LAYAIP---QWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNG-KKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFA----------YYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILAL--------TFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVS----NLWTRVGSMVSPLVKITGEVQPFIPNIIY--GITALLGGSAALFLPETLNQPLPETIEDLENWSVTASG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="533" CheckSum="e9cb1b35b2a4d2daa9e052bbd79c33b6">
    <Seq>
      MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR
      PPHNASTGPW VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV
      YNSTKDSIVT EWDLVCNSNK LKEMAQSIFM AGILIGGLVL GDLSDRFGRR
      PILTCSYLLL AASGSGAAFS PTFPIYMVFR FLCGFGISGI TLSTVILNVE
      WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL TVSIPFFVFF
      LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN
      LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE
      FGVNLYILQI IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL
      TFVPLDLQTV RTVLAVFGKG CLSSSFSCLF LYTSELYPTV IRQTGMGVSN
      LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI TALLGGSAAL FLPETLNQPL
      PETIEDLENW SVTASGPISA PPWGSRSGPR AFP
    </Seq>
  </Sequence>
  <Topology numTm="10" reliability="83.44">
    <Region from="1" to="14" loc="I"/>
    <Region from="15" to="32" loc="M"/>
    <Region from="33" to="123" loc="O"/>
    <Region from="124" to="143" loc="M"/>
    <Region from="144" to="150" loc="I"/>
    <Region from="151" to="169" loc="M"/>
    <Region from="170" to="176" loc="O"/>
    <Region from="177" to="197" loc="M"/>
    <Region from="198" to="207" loc="I"/>
    <Region from="208" to="229" loc="M"/>
    <Region from="230" to="236" loc="O"/>
    <Region from="237" to="255" loc="M"/>
    <Region from="256" to="325" loc="I"/>
    <Region from="326" to="345" loc="M"/>
    <Region from="346" to="354" loc="O"/>
    <Region from="355" to="376" loc="M"/>
    <Region from="377" to="383" loc="I"/>
    <Region from="384" to="404" loc="M"/>
    <Region from="405" to="411" loc="O"/>
    <Region from="412" to="431" loc="M"/>
    <Region from="432" to="533" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="31" loc="M"/>
      <Region from="32" to="126" loc="O"/>
      <Region from="127" to="144" loc="M"/>
      <Region from="145" to="151" loc="I"/>
      <Region from="152" to="170" loc="M"/>
      <Region from="171" to="177" loc="O"/>
      <Region from="178" to="199" loc="M"/>
      <Region from="200" to="207" loc="I"/>
      <Region from="208" to="232" loc="M"/>
      <Region from="233" to="239" loc="O"/>
      <Region from="240" to="256" loc="M"/>
      <Region from="257" to="325" loc="I"/>
      <Region from="326" to="348" loc="M"/>
      <Region from="349" to="355" loc="O"/>
      <Region from="356" to="377" loc="M"/>
      <Region from="378" to="386" loc="I"/>
      <Region from="387" to="405" loc="M"/>
      <Region from="406" to="412" loc="O"/>
      <Region from="413" to="431" loc="M"/>
      <Region from="432" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="41" loc="M"/>
      <Region from="42" to="122" loc="O"/>
      <Region from="123" to="142" loc="M"/>
      <Region from="143" to="149" loc="I"/>
      <Region from="150" to="169" loc="M"/>
      <Region from="170" to="174" loc="O"/>
      <Region from="175" to="199" loc="M"/>
      <Region from="200" to="206" loc="I"/>
      <Region from="207" to="230" loc="M"/>
      <Region from="231" to="237" loc="O"/>
      <Region from="238" to="262" loc="M"/>
      <Region from="263" to="322" loc="I"/>
      <Region from="323" to="346" loc="M"/>
      <Region from="347" to="353" loc="O"/>
      <Region from="354" to="375" loc="M"/>
      <Region from="376" to="384" loc="I"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="408" loc="O"/>
      <Region from="409" to="439" loc="M"/>
      <Region from="440" to="442" loc="I"/>
      <Region from="443" to="466" loc="M"/>
      <Region from="467" to="472" loc="O"/>
      <Region from="473" to="492" loc="M"/>
      <Region from="493" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="17" loc="I"/>
      <Region from="18" to="38" loc="M"/>
      <Region from="39" to="120" loc="O"/>
      <Region from="121" to="141" loc="M"/>
      <Region from="142" to="152" loc="I"/>
      <Region from="153" to="173" loc="M"/>
      <Region from="174" to="175" loc="O"/>
      <Region from="176" to="196" loc="M"/>
      <Region from="197" to="208" loc="I"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="236" loc="O"/>
      <Region from="237" to="257" loc="M"/>
      <Region from="258" to="325" loc="I"/>
      <Region from="326" to="346" loc="M"/>
      <Region from="347" to="353" loc="O"/>
      <Region from="354" to="374" loc="M"/>
      <Region from="375" to="384" loc="I"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="412" loc="O"/>
      <Region from="413" to="433" loc="M"/>
      <Region from="434" to="443" loc="I"/>
      <Region from="444" to="464" loc="M"/>
      <Region from="465" to="470" loc="O"/>
      <Region from="471" to="491" loc="M"/>
      <Region from="492" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="34" loc="M"/>
      <Region from="35" to="123" loc="O"/>
      <Region from="124" to="143" loc="M"/>
      <Region from="144" to="151" loc="I"/>
      <Region from="152" to="171" loc="M"/>
      <Region from="172" to="177" loc="O"/>
      <Region from="178" to="199" loc="M"/>
      <Region from="200" to="208" loc="I"/>
      <Region from="209" to="232" loc="M"/>
      <Region from="233" to="236" loc="O"/>
      <Region from="237" to="256" loc="M"/>
      <Region from="257" to="325" loc="I"/>
      <Region from="326" to="345" loc="M"/>
      <Region from="346" to="354" loc="O"/>
      <Region from="355" to="374" loc="M"/>
      <Region from="375" to="384" loc="I"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="412" loc="O"/>
      <Region from="413" to="433" loc="M"/>
      <Region from="434" to="471" loc="I"/>
      <Region from="472" to="492" loc="M"/>
      <Region from="493" to="533" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="123" loc="O"/>
      <Region from="124" to="140" loc="M"/>
      <Region from="141" to="151" loc="I"/>
      <Region from="152" to="169" loc="M"/>
      <Region from="170" to="174" loc="O"/>
      <Region from="175" to="197" loc="M"/>
      <Region from="198" to="208" loc="I"/>
      <Region from="209" to="231" loc="M"/>
      <Region from="232" to="236" loc="O"/>
      <Region from="237" to="256" loc="M"/>
      <Region from="257" to="325" loc="I"/>
      <Region from="326" to="344" loc="M"/>
      <Region from="345" to="355" loc="O"/>
      <Region from="356" to="380" loc="M"/>
      <Region from="381" to="386" loc="I"/>
      <Region from="387" to="407" loc="M"/>
      <Region from="408" to="412" loc="O"/>
      <Region from="413" to="432" loc="M"/>
      <Region from="433" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="123" loc="O"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="150" loc="I"/>
      <Region from="151" to="171" loc="M"/>
      <Region from="172" to="175" loc="O"/>
      <Region from="176" to="196" loc="M"/>
      <Region from="197" to="211" loc="I"/>
      <Region from="212" to="232" loc="M"/>
      <Region from="233" to="236" loc="O"/>
      <Region from="237" to="257" loc="M"/>
      <Region from="258" to="325" loc="I"/>
      <Region from="326" to="346" loc="M"/>
      <Region from="347" to="356" loc="O"/>
      <Region from="357" to="377" loc="M"/>
      <Region from="378" to="386" loc="I"/>
      <Region from="387" to="407" loc="M"/>
      <Region from="408" to="411" loc="O"/>
      <Region from="412" to="432" loc="M"/>
      <Region from="433" to="447" loc="I"/>
      <Region from="448" to="468" loc="M"/>
      <Region from="469" to="472" loc="O"/>
      <Region from="473" to="493" loc="M"/>
      <Region from="494" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="123" loc="O"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="153" loc="I"/>
      <Region from="154" to="174" loc="M"/>
      <Region from="175" to="178" loc="O"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="210" loc="I"/>
      <Region from="211" to="231" loc="M"/>
      <Region from="232" to="235" loc="O"/>
      <Region from="236" to="256" loc="M"/>
      <Region from="257" to="328" loc="I"/>
      <Region from="329" to="349" loc="M"/>
      <Region from="350" to="354" loc="O"/>
      <Region from="355" to="375" loc="M"/>
      <Region from="376" to="384" loc="I"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="409" loc="O"/>
      <Region from="410" to="430" loc="M"/>
      <Region from="431" to="445" loc="I"/>
      <Region from="446" to="466" loc="M"/>
      <Region from="467" to="471" loc="O"/>
      <Region from="472" to="492" loc="M"/>
      <Region from="493" to="533" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="123" loc="O"/>
      <Region from="124" to="143" loc="M"/>
      <Region from="144" to="152" loc="I"/>
      <Region from="153" to="172" loc="M"/>
      <Region from="173" to="176" loc="O"/>
      <Region from="177" to="196" loc="M"/>
      <Region from="197" to="211" loc="I"/>
      <Region from="212" to="231" loc="M"/>
      <Region from="232" to="235" loc="O"/>
      <Region from="236" to="255" loc="M"/>
      <Region from="256" to="320" loc="I"/>
      <Region from="321" to="340" loc="M"/>
      <Region from="341" to="354" loc="O"/>
      <Region from="355" to="374" loc="M"/>
      <Region from="375" to="386" loc="I"/>
      <Region from="387" to="406" loc="M"/>
      <Region from="407" to="412" loc="O"/>
      <Region from="413" to="432" loc="M"/>
      <Region from="433" to="475" loc="I"/>
      <Region from="476" to="495" loc="M"/>
      <Region from="496" to="533" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="123" loc="O"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="150" loc="I"/>
      <Region from="151" to="171" loc="M"/>
      <Region from="172" to="176" loc="O"/>
      <Region from="177" to="197" loc="M"/>
      <Region from="198" to="211" loc="I"/>
      <Region from="212" to="232" loc="M"/>
      <Region from="233" to="235" loc="O"/>
      <Region from="236" to="256" loc="M"/>
      <Region from="257" to="325" loc="I"/>
      <Region from="326" to="346" loc="M"/>
      <Region from="347" to="356" loc="O"/>
      <Region from="357" to="377" loc="M"/>
      <Region from="378" to="384" loc="I"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="411" loc="O"/>
      <Region from="412" to="432" loc="M"/>
      <Region from="433" to="471" loc="I"/>
      <Region from="472" to="492" loc="M"/>
      <Region from="493" to="533" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="14" loc="O"/>
      <Region from="15" to="37" loc="M"/>
      <Region from="38" to="126" loc="I"/>
      <Region from="127" to="144" loc="M"/>
      <Region from="145" to="176" loc="O"/>
      <Region from="177" to="199" loc="M"/>
      <Region from="200" to="210" loc="I"/>
      <Region from="211" to="233" loc="M"/>
      <Region from="234" to="242" loc="O"/>
      <Region from="243" to="265" loc="M"/>
      <Region from="266" to="325" loc="I"/>
      <Region from="326" to="348" loc="M"/>
      <Region from="349" to="357" loc="O"/>
      <Region from="358" to="380" loc="M"/>
      <Region from="381" to="386" loc="I"/>
      <Region from="387" to="409" loc="M"/>
      <Region from="410" to="533" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et6_A">
      <ConstraintRegion from="2" to="22" loc="I" subId="17063776" subSource="8et6_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063778" subSource="8et6_A"/>
      <ConstraintRegion from="40" to="150" loc="O" subId="17063780" subSource="8et6_A"/>
      <ConstraintRegion from="151" to="167" loc="H" subId="17063782" subSource="8et6_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063784" subSource="8et6_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063786" subSource="8et6_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063788" subSource="8et6_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063790" subSource="8et6_A"/>
      <ConstraintRegion from="222" to="234" loc="I" subId="17063792" subSource="8et6_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17063794" subSource="8et6_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063796" subSource="8et6_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063798" subSource="8et6_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063800" subSource="8et6_A"/>
      <ConstraintRegion from="349" to="366" loc="H" subId="17063802" subSource="8et6_A"/>
      <ConstraintRegion from="367" to="379" loc="O" subId="17063804" subSource="8et6_A"/>
      <ConstraintRegion from="380" to="397" loc="H" subId="17063805" subSource="8et6_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063806" subSource="8et6_A"/>
      <ConstraintRegion from="403" to="422" loc="H" subId="17063807" subSource="8et6_A"/>
      <ConstraintRegion from="423" to="433" loc="O" subId="17063808" subSource="8et6_A"/>
      <ConstraintRegion from="434" to="453" loc="H" subId="17063809" subSource="8et6_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063810" subSource="8et6_A"/>
      <ConstraintRegion from="467" to="484" loc="H" subId="17063811" subSource="8et6_A"/>
      <ConstraintRegion from="485" to="494" loc="O" subId="17063812" subSource="8et6_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="17063813" subSource="8et6_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063814" subSource="8et6_A"/>
      <ConstraintRegion from="2" to="22" loc="I" subId="17063817" subSource="8et7_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063818" subSource="8et7_A"/>
      <ConstraintRegion from="40" to="151" loc="O" subId="17063819" subSource="8et7_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17063820" subSource="8et7_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063821" subSource="8et7_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063822" subSource="8et7_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063823" subSource="8et7_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063824" subSource="8et7_A"/>
      <ConstraintRegion from="222" to="235" loc="I" subId="17063825" subSource="8et7_A"/>
      <ConstraintRegion from="236" to="254" loc="H" subId="17063826" subSource="8et7_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063827" subSource="8et7_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063828" subSource="8et7_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063829" subSource="8et7_A"/>
      <ConstraintRegion from="349" to="365" loc="H" subId="17063830" subSource="8et7_A"/>
      <ConstraintRegion from="366" to="380" loc="O" subId="17063831" subSource="8et7_A"/>
      <ConstraintRegion from="381" to="397" loc="H" subId="17063832" subSource="8et7_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063833" subSource="8et7_A"/>
      <ConstraintRegion from="403" to="419" loc="H" subId="17063834" subSource="8et7_A"/>
      <ConstraintRegion from="420" to="434" loc="O" subId="17063835" subSource="8et7_A"/>
      <ConstraintRegion from="435" to="453" loc="H" subId="17063836" subSource="8et7_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063837" subSource="8et7_A"/>
      <ConstraintRegion from="467" to="483" loc="H" subId="17063838" subSource="8et7_A"/>
      <ConstraintRegion from="484" to="495" loc="O" subId="17063839" subSource="8et7_A"/>
      <ConstraintRegion from="496" to="511" loc="H" subId="17063840" subSource="8et7_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063841" subSource="8et7_A"/>
      <ConstraintRegion from="2" to="20" loc="I" subId="17063877" subSource="8et8_A"/>
      <ConstraintRegion from="21" to="41" loc="H" subId="17063878" subSource="8et8_A"/>
      <ConstraintRegion from="42" to="150" loc="O" subId="17063879" subSource="8et8_A"/>
      <ConstraintRegion from="151" to="170" loc="H" subId="17063880" subSource="8et8_A"/>
      <ConstraintRegion from="171" to="175" loc="I" subId="17063881" subSource="8et8_A"/>
      <ConstraintRegion from="176" to="196" loc="H" subId="17063882" subSource="8et8_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063883" subSource="8et8_A"/>
      <ConstraintRegion from="201" to="222" loc="H" subId="17063884" subSource="8et8_A"/>
      <ConstraintRegion from="223" to="234" loc="I" subId="17063885" subSource="8et8_A"/>
      <ConstraintRegion from="235" to="255" loc="H" subId="17063886" subSource="8et8_A"/>
      <ConstraintRegion from="256" to="262" loc="O" subId="17063887" subSource="8et8_A"/>
      <ConstraintRegion from="263" to="281" loc="H" subId="17063888" subSource="8et8_A"/>
      <ConstraintRegion from="282" to="347" loc="I" subId="17063889" subSource="8et8_A"/>
      <ConstraintRegion from="348" to="368" loc="H" subId="17063890" subSource="8et8_A"/>
      <ConstraintRegion from="369" to="377" loc="O" subId="17063891" subSource="8et8_A"/>
      <ConstraintRegion from="378" to="397" loc="H" subId="17063892" subSource="8et8_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063893" subSource="8et8_A"/>
      <ConstraintRegion from="403" to="423" loc="H" subId="17063894" subSource="8et8_A"/>
      <ConstraintRegion from="424" to="430" loc="O" subId="17063895" subSource="8et8_A"/>
      <ConstraintRegion from="431" to="454" loc="H" subId="17063896" subSource="8et8_A"/>
      <ConstraintRegion from="455" to="463" loc="I" subId="17063897" subSource="8et8_A"/>
      <ConstraintRegion from="464" to="484" loc="H" subId="17063898" subSource="8et8_A"/>
      <ConstraintRegion from="485" to="493" loc="O" subId="17063899" subSource="8et8_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="17063900" subSource="8et8_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063901" subSource="8et8_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
