<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H7BZC0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 22 member 5 </Name>
  <CrossRef>
    <PDBTM id="8et6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zha">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jty">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ju0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jts">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8yf0">
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8yf1">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7wsm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7wsn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7sp5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8fvz">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8jlf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jlh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8js8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ja3">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="OCTN2_HUMAN">
      <Alignment>
        <CrossRefSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLG-----------------------------------------------------MAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLP---RDRQGQPESCLRFTSPQWGLPFLNGTEA-----NGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSM</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSE----LQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A2_RABIT">
      <Alignment>
        <CrossRefSeq>MPTVDDILEQVGHFHFFQKQTFFLLALISAAFTPIYVGIVFLGFTPDHRCRSPGVAELSQRCGWSPGEELNYTVPGLGAADGAFARQCMRYEVDWNQSSPGCVDPLASLAPNRSHLPLGPCQHGWVYDTPG--SSIVTEFNLVCARSWMLDLFQSAVNIGFFIGSVGIGYLADRFGRKLCLLVTILINAAAGVLMAVSPNYTWMLIFRLIQGLVSKAGWLIGYILITEFVGLNYRRTVGILYQVAFTVGLLVLAGVAYALPRWRWLQLTVTLPYFCFLLYYWCIPESPRWLISQNKNAKAMRIMEHIAKKNGKSLPVSLQSLRAAEDVGEKL--NPSFLDLVRTPQIRKHTCILMYNWFTSSVLYQGLIMHLGLAGGDIYLDFFYSALVEFPAAFLIIATIDRVGRRYPWAVSNMVAGAACLASVFVPDDLQGLRITVACLGRMGITMAYEMVCLVNAELYPTFIRNLGVLVCSSLCDVGGIVTPFLVY</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS--SAW-----RNHTVPLRLRDGREVPHSCRRYRLATIAN-FSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPL---DKQGRPESCLRFPFPHNG-----------TEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISM</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQ----DLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLD</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPD---AANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLE-QESCLDGWEFSQDVYLSTIVT--EWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLS--SKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22AB_HUMAN">
      <Alignment>
        <CrossRefSeq>FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSW----SEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILM</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHT-----VPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSEL---QDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORCT_DROME">
      <Alignment>
        <CrossRefSeq>YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPEN----ERCSYYDVDYTEEYLNGSI------PRSSNETKTC-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLL</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFD-------PSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCT1_CAEEL">
      <Alignment>
        <CrossRefSeq>PDFDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHTCHIPEGKEYLRPLTNDTQIL----------SCKQYNETQINVFRAF-TSAPVDTYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNGKSNVDVDELVDSMKNHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNL</CrossRefSeq>
        <OrigSeq>RDYDEVTAFLGEWGPFQRLIFFLLSAS-IIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL----------------------------------------------------VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIF-----DPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT13_YEAST">
      <Alignment>
        <CrossRefSeq>SNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYDNTAQWRVPLGLCFLWALIIIIGMLLVPESPRYLIECERHEEARAS---IAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFIT</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQ------------------------------------------IFSKNFEMFVVLFVLVGMG-----------------QISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQ----DLSSKKQQSHNILDLL--RTWNIRMVTIMSIM-----LWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV--------------PPDLYYLATVLVMVGKFGVTAAF-SMVYVYTAELYPTVVRNMGVGVSSTASRLG----SILSPYFV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GLUT4_HUMAN">
      <Alignment>
        <CrossRefSeq>PQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWAL----------SVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAEL---KDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFII</CrossRefSeq>
        <OrigSeq>PGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSK---NFEMFVVLFVLVGM-----------------------------------------------GQISNYVAAFVLGM----------AIRFIPESPRWLISQGRFE-EAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMS------IMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATAL-------FLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YGCS_ECOLI">
      <Alignment>
        <CrossRefSeq>LLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHR------------YFGPHVLLGDEVVTATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVI-YTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACL--PSGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVS</CrossRefSeq>
        <OrigSeq>FVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQIS---------------------------NYVAAFVLG------------------------------MAIRFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI------MSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YDJE_ECOLI">
      <Alignment>
        <CrossRefSeq>YSGNVVLAKLVSNGW----SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAECQLREVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRR-TLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGV</CrossRefSeq>
        <OrigSeq>FSQDVYLSTIVTE-WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG---------------------------------------------------QISNYVAAFVLGMAIRFI-----PESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVN---CFLSAMVEVPAY----VLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTA-AFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_RAT">
      <Alignment>
        <CrossRefSeq>SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTME</CrossRefSeq>
        <OrigSeq>SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNF--------------------------------------EMFVVLFVLVGM------------------------------GQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIR--------------KAAKANGIVVPSTIFDPSELQDLSSK---------KQQSHNI-LDLLRTWN--IRMVTIMSIMLWMTISVGYFGLSLDTP----NLHGDIFVNCFLSAMVEVPAYVLAWLLLQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_HUMAN">
      <Alignment>
        <CrossRefSeq>SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTME</CrossRefSeq>
        <OrigSeq>SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNF--------------------------------------EMFVVLFVLVGM------------------------------GQISNYVAAFVLGMAIRFIPESPRWLISQGRFEEAEVIIR--------------KAAKANGIVVPSTIFDPSELQDLSSK---------KQQSHNI-LDLLRTWN--IRMVTIMSIMLWMTISVGYFGLSLDTPN----LHGDIFVNCFLSAMVEVPAYVLAWLLLQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MHPT_ECOLI">
      <Alignment>
        <CrossRefSeq>SAGILGLLPGALVGGMLADRYGRKRILIGSVALFGLFSLATAIAWDFPSLVFARLMTGVGLGAALPNLIALTSEAAGPRFRGTAVSLMYCGVPIGAALAATLGFAGANLAWQTVFWVGGVVPL-ILVPLLMRWLPESAVFAGEKQSAPPLRALFAPETATATLLLWLCYFFTLLVVYMLINWLPLLLVEQGFQPSQAAGVMFALQMGAASGTLMLGALMDKLRPVTMSLLIYSGMLASLLALGTVSSFNGMLLAGFVAGLFATGGQSVLYALAPLFYSSQIRATGVGTAVAVGRLGAMSGPLLA</CrossRefSeq>
        <OrigSeq>SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVL--VGMGQISNYVAAFVLGMAIRFIPESPRWLISQGRF-EEAEVIIRKAAKAN---------GIVVPSTIFDPSELQDLSSK-----KQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDI-FVNCFLSAMV---EVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLV-MVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GTR12_MOUSE">
      <Alignment>
        <CrossRefSeq>LTCHEQ---EMVVSSLLIGAFLASLTGGVLIDRYGRRLAIILSSCLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEESAGKVLRKLRVI------SDTTEELTLIKSSLKDEYQYSFWDLFRSKDNMRTRILIGLTLVFFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHIGSKTFLCIGSSVMSASLLTMGIV</CrossRefSeq>
        <OrigSeq>LVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGM---------------------------------------GQISNYVAA-------FVLGMAI----------RFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTW-NIRMVTIM-SIMLWMTISVG------YFGLSLDTPNLHGDIFVNCFLS--AMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2A_HUMAN">
      <Alignment>
        <CrossRefSeq>CLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWL</CrossRefSeq>
        <OrigSeq>CEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGM---GQISNYVAAFVLGMAIRFIPESPRWL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT9_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINKWYQYFIGRIISGLGVGGIAVLSPMLI</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEM-FVVLFVLVGMGQISNYVAAFVLG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT8_YEAST">
      <Alignment>
        <CrossRefSeq>SNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGIVIQIASIDKWYQYFIGRIIAGIGAGSISVLAPMLI</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEM-FVVLFVLVGMGQISNYVAAFVLG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT11_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINKWYQYFIGRIISGLGVGGIAVLSPMLI</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEM-FVVLFVLVGMGQISNYVAAFVLG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT2_YEAST">
      <Alignment>
        <CrossRefSeq>SDVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGMGVGGIAVLSPTLI</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEM-FVVLFVLVGMGQISNYVAAFVLG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="431" CheckSum="c2347c286c08a5d66c305cc0688767c8">
    <Seq>
      MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFTGLSSV FLIATPEHRC
      RVPDAANLSS AWRNHTVPLR LRDGREVPHS CRRYRLATIA NFSALGLEPG
      RDVDLGQLEQ ESCLDGWEFS QDVYLSTIVT EWNLVCEDDW KAPLTISLFF
      VGVLLGSFIS GQLSDRFGRK NVLFVTMGMQ TGFSFLQIFS KNFEMFVVLF
      VLVGMGQISN YVAAFVLGMA IRFIPESPRW LISQGRFEEA EVIIRKAAKA
      NGIVVPSTIF DPSELQDLSS KKQQSHNILD LLRTWNIRMV TIMSIMLWMT
      ISVGYFGLSL DTPNLHGDIF VNCFLSAMVE VPAYVLAWLL LQYLPRRYSM
      ATALFLGGSV LLFMQLVPPD LYYLATVLVM VGKFGVTAAF SMVYVYTAEL
      YPTVVRNMGV GVSSTASRLG SILSPYFVYL E
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="87.33">
    <Region from="1" to="19" loc="I"/>
    <Region from="20" to="42" loc="M"/>
    <Region from="43" to="142" loc="O"/>
    <Region from="143" to="163" loc="M"/>
    <Region from="164" to="170" loc="I"/>
    <Region from="171" to="189" loc="M"/>
    <Region from="190" to="196" loc="O"/>
    <Region from="197" to="220" loc="M"/>
    <Region from="221" to="288" loc="I"/>
    <Region from="289" to="309" loc="M"/>
    <Region from="310" to="318" loc="O"/>
    <Region from="319" to="340" loc="M"/>
    <Region from="341" to="347" loc="I"/>
    <Region from="348" to="366" loc="M"/>
    <Region from="367" to="373" loc="O"/>
    <Region from="374" to="395" loc="M"/>
    <Region from="396" to="431" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="171" loc="I"/>
      <Region from="172" to="191" loc="M"/>
      <Region from="192" to="196" loc="O"/>
      <Region from="197" to="221" loc="M"/>
      <Region from="222" to="288" loc="I"/>
      <Region from="289" to="310" loc="M"/>
      <Region from="311" to="318" loc="O"/>
      <Region from="319" to="341" loc="M"/>
      <Region from="342" to="348" loc="I"/>
      <Region from="349" to="367" loc="M"/>
      <Region from="368" to="374" loc="O"/>
      <Region from="375" to="396" loc="M"/>
      <Region from="397" to="431" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="43" loc="M"/>
      <Region from="44" to="144" loc="O"/>
      <Region from="145" to="163" loc="M"/>
      <Region from="164" to="169" loc="I"/>
      <Region from="170" to="190" loc="M"/>
      <Region from="191" to="194" loc="O"/>
      <Region from="195" to="225" loc="M"/>
      <Region from="226" to="285" loc="I"/>
      <Region from="286" to="310" loc="M"/>
      <Region from="311" to="318" loc="O"/>
      <Region from="319" to="340" loc="M"/>
      <Region from="341" to="348" loc="I"/>
      <Region from="349" to="367" loc="M"/>
      <Region from="368" to="370" loc="O"/>
      <Region from="371" to="401" loc="M"/>
      <Region from="402" to="404" loc="I"/>
      <Region from="405" to="428" loc="M"/>
      <Region from="429" to="431" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="46" loc="M"/>
      <Region from="47" to="141" loc="O"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="171" loc="I"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="193" loc="O"/>
      <Region from="194" to="224" loc="M"/>
      <Region from="225" to="289" loc="I"/>
      <Region from="290" to="310" loc="M"/>
      <Region from="311" to="316" loc="O"/>
      <Region from="317" to="337" loc="M"/>
      <Region from="338" to="347" loc="I"/>
      <Region from="348" to="368" loc="M"/>
      <Region from="369" to="376" loc="O"/>
      <Region from="377" to="397" loc="M"/>
      <Region from="398" to="407" loc="I"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="431" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="43" loc="M"/>
      <Region from="44" to="141" loc="O"/>
      <Region from="142" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="189" loc="M"/>
      <Region from="190" to="196" loc="O"/>
      <Region from="197" to="221" loc="M"/>
      <Region from="222" to="286" loc="I"/>
      <Region from="287" to="308" loc="M"/>
      <Region from="309" to="318" loc="O"/>
      <Region from="319" to="341" loc="M"/>
      <Region from="342" to="347" loc="I"/>
      <Region from="348" to="367" loc="M"/>
      <Region from="368" to="373" loc="O"/>
      <Region from="374" to="396" loc="M"/>
      <Region from="397" to="407" loc="I"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="431" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="139" loc="O"/>
      <Region from="140" to="159" loc="M"/>
      <Region from="160" to="170" loc="I"/>
      <Region from="171" to="189" loc="M"/>
      <Region from="190" to="194" loc="O"/>
      <Region from="195" to="221" loc="M"/>
      <Region from="222" to="284" loc="I"/>
      <Region from="285" to="307" loc="M"/>
      <Region from="308" to="318" loc="O"/>
      <Region from="319" to="341" loc="M"/>
      <Region from="342" to="347" loc="I"/>
      <Region from="348" to="366" loc="M"/>
      <Region from="367" to="371" loc="O"/>
      <Region from="372" to="396" loc="M"/>
      <Region from="397" to="431" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="173" loc="I"/>
      <Region from="174" to="194" loc="M"/>
      <Region from="195" to="204" loc="O"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="289" loc="I"/>
      <Region from="290" to="310" loc="M"/>
      <Region from="311" to="320" loc="O"/>
      <Region from="321" to="341" loc="M"/>
      <Region from="342" to="350" loc="I"/>
      <Region from="351" to="371" loc="M"/>
      <Region from="372" to="375" loc="O"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="407" loc="I"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="431" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="141" loc="O"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="171" loc="I"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="200" loc="O"/>
      <Region from="201" to="221" loc="M"/>
      <Region from="222" to="289" loc="I"/>
      <Region from="290" to="310" loc="M"/>
      <Region from="311" to="318" loc="O"/>
      <Region from="319" to="339" loc="M"/>
      <Region from="340" to="348" loc="I"/>
      <Region from="349" to="369" loc="M"/>
      <Region from="370" to="377" loc="O"/>
      <Region from="378" to="398" loc="M"/>
      <Region from="399" to="407" loc="I"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="431" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="36" loc="M"/>
      <Region from="37" to="142" loc="I"/>
      <Region from="143" to="162" loc="M"/>
      <Region from="163" to="192" loc="O"/>
      <Region from="193" to="212" loc="M"/>
      <Region from="213" to="280" loc="I"/>
      <Region from="281" to="300" loc="M"/>
      <Region from="301" to="323" loc="O"/>
      <Region from="324" to="343" loc="M"/>
      <Region from="344" to="347" loc="I"/>
      <Region from="348" to="367" loc="M"/>
      <Region from="368" to="369" loc="O"/>
      <Region from="370" to="390" loc="M"/>
      <Region from="391" to="431" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="37" loc="M"/>
      <Region from="38" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="204" loc="O"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="289" loc="I"/>
      <Region from="290" to="310" loc="M"/>
      <Region from="311" to="320" loc="O"/>
      <Region from="321" to="341" loc="M"/>
      <Region from="342" to="348" loc="I"/>
      <Region from="349" to="369" loc="M"/>
      <Region from="370" to="375" loc="O"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="431" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="43" loc="M"/>
      <Region from="44" to="141" loc="O"/>
      <Region from="142" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="194" loc="O"/>
      <Region from="195" to="217" loc="M"/>
      <Region from="218" to="286" loc="I"/>
      <Region from="287" to="309" loc="M"/>
      <Region from="310" to="318" loc="O"/>
      <Region from="319" to="341" loc="M"/>
      <Region from="342" to="347" loc="I"/>
      <Region from="348" to="367" loc="M"/>
      <Region from="368" to="371" loc="O"/>
      <Region from="372" to="394" loc="M"/>
      <Region from="395" to="431" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et6_A">
      <ConstraintRegion from="2" to="22" loc="I" subId="17063776" subSource="8et6_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063778" subSource="8et6_A"/>
      <ConstraintRegion from="40" to="150" loc="O" subId="17063780" subSource="8et6_A"/>
      <ConstraintRegion from="151" to="167" loc="H" subId="17063782" subSource="8et6_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063784" subSource="8et6_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063786" subSource="8et6_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063788" subSource="8et6_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063790" subSource="8et6_A"/>
      <ConstraintRegion from="222" to="234" loc="I" subId="17063792" subSource="8et6_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17063794" subSource="8et6_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063796" subSource="8et6_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063798" subSource="8et6_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063800" subSource="8et6_A"/>
      <ConstraintRegion from="349" to="366" loc="H" subId="17063802" subSource="8et6_A"/>
      <ConstraintRegion from="367" to="379" loc="O" subId="17063804" subSource="8et6_A"/>
      <ConstraintRegion from="380" to="397" loc="H" subId="17063805" subSource="8et6_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063806" subSource="8et6_A"/>
      <ConstraintRegion from="403" to="422" loc="H" subId="17063807" subSource="8et6_A"/>
      <ConstraintRegion from="423" to="433" loc="O" subId="17063808" subSource="8et6_A"/>
      <ConstraintRegion from="434" to="453" loc="H" subId="17063809" subSource="8et6_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063810" subSource="8et6_A"/>
      <ConstraintRegion from="467" to="484" loc="H" subId="17063811" subSource="8et6_A"/>
      <ConstraintRegion from="485" to="494" loc="O" subId="17063812" subSource="8et6_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="17063813" subSource="8et6_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063814" subSource="8et6_A"/>
      <ConstraintRegion from="2" to="22" loc="I" subId="17063817" subSource="8et7_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063818" subSource="8et7_A"/>
      <ConstraintRegion from="40" to="151" loc="O" subId="17063819" subSource="8et7_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17063820" subSource="8et7_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063821" subSource="8et7_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063822" subSource="8et7_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063823" subSource="8et7_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063824" subSource="8et7_A"/>
      <ConstraintRegion from="222" to="235" loc="I" subId="17063825" subSource="8et7_A"/>
      <ConstraintRegion from="236" to="254" loc="H" subId="17063826" subSource="8et7_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063827" subSource="8et7_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063828" subSource="8et7_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063829" subSource="8et7_A"/>
      <ConstraintRegion from="349" to="365" loc="H" subId="17063830" subSource="8et7_A"/>
      <ConstraintRegion from="366" to="380" loc="O" subId="17063831" subSource="8et7_A"/>
      <ConstraintRegion from="381" to="397" loc="H" subId="17063832" subSource="8et7_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063833" subSource="8et7_A"/>
      <ConstraintRegion from="403" to="419" loc="H" subId="17063834" subSource="8et7_A"/>
      <ConstraintRegion from="420" to="434" loc="O" subId="17063835" subSource="8et7_A"/>
      <ConstraintRegion from="435" to="453" loc="H" subId="17063836" subSource="8et7_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063837" subSource="8et7_A"/>
      <ConstraintRegion from="467" to="483" loc="H" subId="17063838" subSource="8et7_A"/>
      <ConstraintRegion from="484" to="495" loc="O" subId="17063839" subSource="8et7_A"/>
      <ConstraintRegion from="496" to="511" loc="H" subId="17063840" subSource="8et7_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063841" subSource="8et7_A"/>
      <ConstraintRegion from="2" to="20" loc="I" subId="17063877" subSource="8et8_A"/>
      <ConstraintRegion from="21" to="41" loc="H" subId="17063878" subSource="8et8_A"/>
      <ConstraintRegion from="42" to="150" loc="O" subId="17063879" subSource="8et8_A"/>
      <ConstraintRegion from="151" to="170" loc="H" subId="17063880" subSource="8et8_A"/>
      <ConstraintRegion from="171" to="175" loc="I" subId="17063881" subSource="8et8_A"/>
      <ConstraintRegion from="176" to="196" loc="H" subId="17063882" subSource="8et8_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063883" subSource="8et8_A"/>
      <ConstraintRegion from="201" to="222" loc="H" subId="17063884" subSource="8et8_A"/>
      <ConstraintRegion from="223" to="234" loc="I" subId="17063885" subSource="8et8_A"/>
      <ConstraintRegion from="235" to="255" loc="H" subId="17063886" subSource="8et8_A"/>
      <ConstraintRegion from="256" to="262" loc="O" subId="17063887" subSource="8et8_A"/>
      <ConstraintRegion from="263" to="281" loc="H" subId="17063888" subSource="8et8_A"/>
      <ConstraintRegion from="282" to="347" loc="I" subId="17063889" subSource="8et8_A"/>
      <ConstraintRegion from="348" to="368" loc="H" subId="17063890" subSource="8et8_A"/>
      <ConstraintRegion from="369" to="377" loc="O" subId="17063891" subSource="8et8_A"/>
      <ConstraintRegion from="378" to="397" loc="H" subId="17063892" subSource="8et8_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063893" subSource="8et8_A"/>
      <ConstraintRegion from="403" to="423" loc="H" subId="17063894" subSource="8et8_A"/>
      <ConstraintRegion from="424" to="430" loc="O" subId="17063895" subSource="8et8_A"/>
      <ConstraintRegion from="431" to="454" loc="H" subId="17063896" subSource="8et8_A"/>
      <ConstraintRegion from="455" to="463" loc="I" subId="17063897" subSource="8et8_A"/>
      <ConstraintRegion from="464" to="484" loc="H" subId="17063898" subSource="8et8_A"/>
      <ConstraintRegion from="485" to="493" loc="O" subId="17063899" subSource="8et8_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="17063900" subSource="8et8_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063901" subSource="8et8_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
