<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H7C140_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Purinergic receptor P2X 6 </Name>
  <CrossRef>
    <PDBTM id="5svk">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6ah4">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6ah5">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6u9v">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6u9w">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4dw0">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3h9v">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="5svl">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3i5d">
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4dw1">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="5wzy">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5svq">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5svj">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5svs">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5svt">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5svr">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5yve">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8jv5">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5svm">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5svp">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8jv6">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5f1c">
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5u1w">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="5u1x">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8jv7">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8jv8">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5u1v">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="5u1l">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5u1y">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5u2h">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="5u1u">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5xw6">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="P2RX4_HUMAN">
      <Alignment>
        <CrossRefSeq>MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP</CrossRefSeq>
        <OrigSeq>MGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQAAG---------FRPFQSTRAQPGQP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="P2RX4_RAT">
      <Alignment>
        <CrossRefSeq>MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVIPAQEENSLFIMTNMIVTVNQTQSTCPEIP</CrossRefSeq>
        <OrigSeq>MGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQAAG---------FRPFQSTRAQPGQP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="P2RX7_HUMAN">
      <Alignment>
        <CrossRefSeq>PACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVC-FALVSDKLYQRKEPVI-SSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYP</CrossRefSeq>
        <OrigSeq>PGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQ-------IKELGNRLWDVADFVKPPQAAGF--------RPFQSTRAQPGQP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="P2RX7_MOUSE">
      <Alignment>
        <CrossRefSeq>PACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVI-SSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYP</CrossRefSeq>
        <OrigSeq>PGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQ-------IKELGNRLWDVADFVKPPQAAGF--------RPFQSTRAQPGQP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="P2RX3_HUMAN">
      <Alignment>
        <CrossRefSeq>SDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPE</CrossRefSeq>
        <OrigSeq>WGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQAAG---------FRPFQSTRAQPG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="120" CheckSum="714675b24204361be2752d69438f947b">
    <Seq>
      XQLAGAGSMG SPGATTGWGL LDYKTEKYVM TRNWRVGALQ RLLQFGIVVY
      VVGWALLAKK GYQERDLEPQ FSIITKLKGV SVTQIKELGN RLWDVADFVK
      PPQAAGFRPF QSTRAQPGQP 
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="63.98">
    <Region from="1" to="35" loc="I"/>
    <Region from="36" to="57" loc="M"/>
    <Region from="58" to="120" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="21" loc="M"/>
      <Region from="22" to="44" loc="I"/>
      <Region from="45" to="58" loc="M"/>
      <Region from="59" to="120" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="37" loc="O"/>
      <Region from="38" to="57" loc="M"/>
      <Region from="58" to="120" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="22" loc="M"/>
      <Region from="23" to="35" loc="I"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="120" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="37" loc="I"/>
      <Region from="38" to="58" loc="M"/>
      <Region from="59" to="120" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="37" loc="O"/>
      <Region from="38" to="57" loc="M"/>
      <Region from="58" to="120" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="37" loc="I"/>
      <Region from="38" to="58" loc="M"/>
      <Region from="59" to="120" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="35" loc="I"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="120" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="37" loc="O"/>
      <Region from="38" to="57" loc="M"/>
      <Region from="58" to="120" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="37" loc="I"/>
      <Region from="38" to="58" loc="M"/>
      <Region from="59" to="120" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="35" loc="O"/>
      <Region from="36" to="58" loc="M"/>
      <Region from="59" to="120" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="4dw0_A">
      <ConstraintRegion from="32" to="36" loc="I" subId="17040452" subSource="4dw0_A"/>
      <ConstraintRegion from="37" to="55" loc="H" subId="17040453" subSource="4dw0_A"/>
      <ConstraintRegion from="56" to="331" loc="O" subId="17040454" subSource="4dw0_A"/>
      <ConstraintRegion from="332" to="356" loc="H" subId="17040455" subSource="4dw0_A"/>
      <ConstraintRegion from="357" to="361" loc="I" subId="17040456" subSource="4dw0_A"/>
      <ConstraintRegion from="32" to="36" loc="I" subId="17040459" subSource="4dw0_C"/>
      <ConstraintRegion from="37" to="55" loc="H" subId="17040460" subSource="4dw0_C"/>
      <ConstraintRegion from="56" to="331" loc="O" subId="17040461" subSource="4dw0_C"/>
      <ConstraintRegion from="332" to="356" loc="H" subId="17040462" subSource="4dw0_C"/>
      <ConstraintRegion from="357" to="361" loc="I" subId="17040463" subSource="4dw0_C"/>
      <ConstraintRegion from="32" to="36" loc="I" subId="17040466" subSource="4dw0_D"/>
      <ConstraintRegion from="37" to="55" loc="H" subId="17040467" subSource="4dw0_D"/>
      <ConstraintRegion from="56" to="331" loc="O" subId="17040468" subSource="4dw0_D"/>
      <ConstraintRegion from="332" to="356" loc="H" subId="17040469" subSource="4dw0_D"/>
      <ConstraintRegion from="357" to="361" loc="I" subId="17040470" subSource="4dw0_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3h9v_A">
      <ConstraintRegion from="32" to="34" loc="I" subId="17103800" subSource="3h9v_A"/>
      <ConstraintRegion from="35" to="55" loc="H" subId="17103802" subSource="3h9v_A"/>
      <ConstraintRegion from="56" to="136" loc="O" subId="17103804" subSource="3h9v_A"/>
      <ConstraintRegion from="138" to="331" loc="O" subId="17103806" subSource="3h9v_A"/>
      <ConstraintRegion from="332" to="360" loc="H" subId="17103808" subSource="3h9v_A"/>
      <ConstraintRegion from="361" to="361" loc="I" subId="17103810" subSource="3h9v_A"/>
      <ConstraintRegion from="32" to="34" loc="I" subId="17103812" subSource="3h9v_D"/>
      <ConstraintRegion from="35" to="55" loc="H" subId="17103814" subSource="3h9v_D"/>
      <ConstraintRegion from="56" to="136" loc="O" subId="17103816" subSource="3h9v_D"/>
      <ConstraintRegion from="138" to="331" loc="O" subId="17103818" subSource="3h9v_D"/>
      <ConstraintRegion from="332" to="360" loc="H" subId="17103819" subSource="3h9v_D"/>
      <ConstraintRegion from="361" to="361" loc="I" subId="17103821" subSource="3h9v_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3i5d_B">
      <ConstraintRegion from="34" to="38" loc="I" subId="17117020" subSource="3i5d_B"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17117022" subSource="3i5d_B"/>
      <ConstraintRegion from="56" to="331" loc="O" subId="17117024" subSource="3i5d_B"/>
      <ConstraintRegion from="332" to="352" loc="H" subId="17117026" subSource="3i5d_B"/>
      <ConstraintRegion from="353" to="361" loc="I" subId="17117028" subSource="3i5d_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3i5d_C">
      <ConstraintRegion from="34" to="38" loc="I" subId="17117036" subSource="3i5d_C"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17117038" subSource="3i5d_C"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17117040" subSource="3i5d_C"/>
      <ConstraintRegion from="331" to="352" loc="H" subId="17117042" subSource="3i5d_C"/>
      <ConstraintRegion from="353" to="358" loc="I" subId="17117044" subSource="3i5d_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3i5d_A">
      <ConstraintRegion from="36" to="38" loc="I" subId="17117013" subSource="3i5d_A"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17117014" subSource="3i5d_A"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17117015" subSource="3i5d_A"/>
      <ConstraintRegion from="331" to="352" loc="H" subId="17117016" subSource="3i5d_A"/>
      <ConstraintRegion from="353" to="359" loc="I" subId="17117017" subSource="3i5d_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4dw1_A">
      <ConstraintRegion from="36" to="40" loc="I" subId="17040473" subSource="4dw1_A"/>
      <ConstraintRegion from="41" to="55" loc="H" subId="17040474" subSource="4dw1_A"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17040475" subSource="4dw1_A"/>
      <ConstraintRegion from="331" to="349" loc="H" subId="17040476" subSource="4dw1_A"/>
      <ConstraintRegion from="350" to="359" loc="I" subId="17040477" subSource="4dw1_A"/>
      <ConstraintRegion from="36" to="38" loc="I" subId="17409601" subSource="5wzy_A"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17409602" subSource="5wzy_A"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17409603" subSource="5wzy_A"/>
      <ConstraintRegion from="331" to="352" loc="H" subId="17409605" subSource="5wzy_A"/>
      <ConstraintRegion from="353" to="359" loc="I" subId="17409607" subSource="5wzy_A"/>
      <ConstraintRegion from="36" to="40" loc="I" subId="17040480" subSource="4dw1_C"/>
      <ConstraintRegion from="41" to="55" loc="H" subId="17040481" subSource="4dw1_C"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17040482" subSource="4dw1_C"/>
      <ConstraintRegion from="331" to="349" loc="H" subId="17040483" subSource="4dw1_C"/>
      <ConstraintRegion from="350" to="359" loc="I" subId="17040484" subSource="4dw1_C"/>
      <ConstraintRegion from="36" to="40" loc="I" subId="17040494" subSource="4dw1_D"/>
      <ConstraintRegion from="41" to="55" loc="H" subId="17040497" subSource="4dw1_D"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17040500" subSource="4dw1_D"/>
      <ConstraintRegion from="331" to="349" loc="H" subId="17040503" subSource="4dw1_D"/>
      <ConstraintRegion from="350" to="359" loc="I" subId="17040505" subSource="4dw1_D"/>
      <ConstraintRegion from="36" to="38" loc="I" subId="17409609" subSource="5wzy_B"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17409611" subSource="5wzy_B"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17409612" subSource="5wzy_B"/>
      <ConstraintRegion from="331" to="352" loc="H" subId="17409613" subSource="5wzy_B"/>
      <ConstraintRegion from="353" to="359" loc="I" subId="17409614" subSource="5wzy_B"/>
      <ConstraintRegion from="36" to="38" loc="I" subId="17409618" subSource="5wzy_C"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17409620" subSource="5wzy_C"/>
      <ConstraintRegion from="56" to="330" loc="O" subId="17409622" subSource="5wzy_C"/>
      <ConstraintRegion from="331" to="352" loc="H" subId="17409623" subSource="5wzy_C"/>
      <ConstraintRegion from="353" to="359" loc="I" subId="17409624" subSource="5wzy_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5f1c_B">
      <ConstraintRegion from="19" to="30" loc="I" subId="17066681" subSource="5f1c_B"/>
      <ConstraintRegion from="31" to="51" loc="H" subId="17066683" subSource="5f1c_B"/>
      <ConstraintRegion from="52" to="342" loc="O" subId="17066684" subSource="5f1c_B"/>
      <ConstraintRegion from="343" to="366" loc="H" subId="17066685" subSource="5f1c_B"/>
      <ConstraintRegion from="367" to="373" loc="I" subId="17066686" subSource="5f1c_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5f1c_C">
      <ConstraintRegion from="29" to="30" loc="I" subId="17066687" subSource="5f1c_C"/>
      <ConstraintRegion from="31" to="51" loc="H" subId="17066688" subSource="5f1c_C"/>
      <ConstraintRegion from="52" to="342" loc="O" subId="17066689" subSource="5f1c_C"/>
      <ConstraintRegion from="343" to="366" loc="H" subId="17066690" subSource="5f1c_C"/>
      <ConstraintRegion from="367" to="372" loc="I" subId="17066692" subSource="5f1c_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5f1c_A">
      <ConstraintRegion from="30" to="30" loc="I" subId="17066670" subSource="5f1c_A"/>
      <ConstraintRegion from="31" to="51" loc="H" subId="17066672" subSource="5f1c_A"/>
      <ConstraintRegion from="52" to="342" loc="O" subId="17066674" subSource="5f1c_A"/>
      <ConstraintRegion from="343" to="366" loc="H" subId="17066676" subSource="5f1c_A"/>
      <ConstraintRegion from="367" to="372" loc="I" subId="17066678" subSource="5f1c_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5xw6_C">
      <ConstraintRegion from="27" to="29" loc="I" subId="17429365" subSource="5xw6_C"/>
      <ConstraintRegion from="30" to="49" loc="H" subId="17429368" subSource="5xw6_C"/>
      <ConstraintRegion from="50" to="313" loc="O" subId="17429371" subSource="5xw6_C"/>
      <ConstraintRegion from="314" to="338" loc="H" subId="17429373" subSource="5xw6_C"/>
      <ConstraintRegion from="339" to="346" loc="I" subId="17429376" subSource="5xw6_C"/>
      <ConstraintRegion from="27" to="29" loc="I" subId="17429383" subSource="5xw6_A"/>
      <ConstraintRegion from="30" to="49" loc="H" subId="17429386" subSource="5xw6_A"/>
      <ConstraintRegion from="50" to="314" loc="O" subId="17429388" subSource="5xw6_A"/>
      <ConstraintRegion from="315" to="338" loc="H" subId="17429391" subSource="5xw6_A"/>
      <ConstraintRegion from="339" to="346" loc="I" subId="17429394" subSource="5xw6_A"/>
      <ConstraintRegion from="27" to="29" loc="I" subId="17429397" subSource="5xw6_B"/>
      <ConstraintRegion from="30" to="49" loc="H" subId="17429399" subSource="5xw6_B"/>
      <ConstraintRegion from="50" to="313" loc="O" subId="17429401" subSource="5xw6_B"/>
      <ConstraintRegion from="314" to="338" loc="H" subId="17429403" subSource="5xw6_B"/>
      <ConstraintRegion from="339" to="346" loc="I" subId="17429405" subSource="5xw6_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
