<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H7C1B9_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 6 member 6 </Name>
  <CrossRef>
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    <TOPDB id="SC6A6_HUMAN">
      <Alignment>
        <CrossRefSeq>PWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPN</CrossRefSeq>
        <OrigSeq>SILFFIMLLLLGLDSQGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DAT_DROME">
      <Alignment>
        <CrossRefSeq>PPGRYWQ---VCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQ</CrossRefSeq>
        <OrigSeq>PLPTFWSILFFIMLLLLGLDSQGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A1_MOUSE">
      <Alignment>
        <CrossRefSeq>WWKLCWSFFTPIIVAGVFLFSAVQMTPLTMG-SYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSED</CrossRefSeq>
        <OrigSeq>ILFFIMLLLLGLDSQGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="INE_DROME">
      <Alignment>
        <CrossRefSeq>PSFY--LRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRSSGDTFWERIRNTLRP</CrossRefSeq>
        <OrigSeq>PTFWSILFFIMLLLLGLDSQGCFIFSLVKYVPLTY-NKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEG-PFLVRVKYLLTP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A4_RAT">
      <Alignment>
        <CrossRefSeq>PGWFW---RICWVAISPLFLLFIICSFLMSPPQLRLFQYN----YPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETP</CrossRefSeq>
        <OrigSeq>LPTFWSILFFIMLLLLGLDSQGC---FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A4_HUMAN">
      <Alignment>
        <CrossRefSeq>PGWFW---RICWVAISPLFLLFIICSFLMSPPQLRLFQYN----YPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP</CrossRefSeq>
        <OrigSeq>LPTFWSILFFIMLLLLGLDSQGC---FIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREP</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="95" CheckSum="50e6070390e4ec9215f47f9154544c48">
    <Seq>
      XTMMPLPTFW SILFFIMLLL LGLDSQGCFI FSLVKYVPLT YNKTYVYPNW
      AIGLGWSLAL SSMLCVPLVI VIRLCQTEGP FLVRVKYLLT PREPN
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="76.91">
    <Region from="1" to="10" loc="I"/>
    <Region from="11" to="33" loc="M"/>
    <Region from="34" to="50" loc="O"/>
    <Region from="51" to="72" loc="M"/>
    <Region from="73" to="95" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="14" loc="O"/>
      <Region from="15" to="34" loc="M"/>
      <Region from="35" to="50" loc="I"/>
      <Region from="51" to="75" loc="M"/>
      <Region from="76" to="95" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="20" loc="O"/>
      <Region from="21" to="36" loc="M"/>
      <Region from="37" to="50" loc="I"/>
      <Region from="51" to="75" loc="M"/>
      <Region from="76" to="95" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="8" loc="O"/>
      <Region from="9" to="23" loc="M"/>
      <Region from="24" to="24" loc="I"/>
      <Region from="25" to="39" loc="M"/>
      <Region from="40" to="49" loc="O"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="95" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="8" loc="I"/>
      <Region from="9" to="33" loc="M"/>
      <Region from="34" to="51" loc="O"/>
      <Region from="52" to="75" loc="M"/>
      <Region from="76" to="95" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="11" loc="O"/>
      <Region from="12" to="23" loc="O"/>
      <Region from="24" to="27" loc="O"/>
      <Region from="28" to="50" loc="O"/>
      <Region from="51" to="74" loc="M"/>
      <Region from="75" to="95" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="51" loc="O"/>
      <Region from="52" to="72" loc="M"/>
      <Region from="73" to="95" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="52" loc="O"/>
      <Region from="53" to="73" loc="M"/>
      <Region from="74" to="95" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="3" loc="I"/>
      <Region from="4" to="24" loc="M"/>
      <Region from="25" to="53" loc="O"/>
      <Region from="54" to="74" loc="M"/>
      <Region from="75" to="95" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="13" loc="I"/>
      <Region from="14" to="34" loc="M"/>
      <Region from="35" to="53" loc="O"/>
      <Region from="54" to="74" loc="M"/>
      <Region from="75" to="95" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="34" loc="M"/>
      <Region from="35" to="48" loc="O"/>
      <Region from="49" to="71" loc="M"/>
      <Region from="72" to="95" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8de3_A">
      <ConstraintRegion from="116" to="123" loc="I" subId="17028566" subSource="8de3_A"/>
      <ConstraintRegion from="124" to="142" loc="H" subId="17028568" subSource="8de3_A"/>
      <ConstraintRegion from="143" to="154" loc="O" subId="17028570" subSource="8de3_A"/>
      <ConstraintRegion from="155" to="174" loc="H" subId="17028572" subSource="8de3_A"/>
      <ConstraintRegion from="175" to="197" loc="I" subId="17028574" subSource="8de3_A"/>
      <ConstraintRegion from="198" to="222" loc="H" subId="17028576" subSource="8de3_A"/>
      <ConstraintRegion from="223" to="288" loc="O" subId="17028578" subSource="8de3_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028580" subSource="8de3_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028582" subSource="8de3_A"/>
      <ConstraintRegion from="314" to="333" loc="H" subId="17028584" subSource="8de3_A"/>
      <ConstraintRegion from="334" to="360" loc="O" subId="17028587" subSource="8de3_A"/>
      <ConstraintRegion from="361" to="382" loc="H" subId="17028589" subSource="8de3_A"/>
      <ConstraintRegion from="383" to="395" loc="I" subId="17028592" subSource="8de3_A"/>
      <ConstraintRegion from="396" to="413" loc="H" subId="17028595" subSource="8de3_A"/>
      <ConstraintRegion from="414" to="462" loc="O" subId="17028598" subSource="8de3_A"/>
      <ConstraintRegion from="463" to="484" loc="H" subId="17028601" subSource="8de3_A"/>
      <ConstraintRegion from="485" to="503" loc="I" subId="17028604" subSource="8de3_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028607" subSource="8de3_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028610" subSource="8de3_A"/>
      <ConstraintRegion from="526" to="548" loc="H" subId="17028613" subSource="8de3_A"/>
      <ConstraintRegion from="549" to="572" loc="I" subId="17028616" subSource="8de3_A"/>
      <ConstraintRegion from="573" to="595" loc="H" subId="17028619" subSource="8de3_A"/>
      <ConstraintRegion from="596" to="612" loc="O" subId="17028622" subSource="8de3_A"/>
      <ConstraintRegion from="613" to="631" loc="H" subId="17028625" subSource="8de3_A"/>
      <ConstraintRegion from="632" to="654" loc="I" subId="17028628" subSource="8de3_A"/>
      <ConstraintRegion from="116" to="123" loc="I" subId="17028648" subSource="8de4_A"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17028651" subSource="8de4_A"/>
      <ConstraintRegion from="140" to="155" loc="O" subId="17028655" subSource="8de4_A"/>
      <ConstraintRegion from="156" to="173" loc="H" subId="17028660" subSource="8de4_A"/>
      <ConstraintRegion from="174" to="201" loc="I" subId="17028664" subSource="8de4_A"/>
      <ConstraintRegion from="202" to="221" loc="H" subId="17028668" subSource="8de4_A"/>
      <ConstraintRegion from="222" to="288" loc="O" subId="17028673" subSource="8de4_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028678" subSource="8de4_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028682" subSource="8de4_A"/>
      <ConstraintRegion from="314" to="330" loc="H" subId="17028685" subSource="8de4_A"/>
      <ConstraintRegion from="331" to="363" loc="O" subId="17028690" subSource="8de4_A"/>
      <ConstraintRegion from="364" to="381" loc="H" subId="17028695" subSource="8de4_A"/>
      <ConstraintRegion from="382" to="395" loc="I" subId="17028699" subSource="8de4_A"/>
      <ConstraintRegion from="396" to="412" loc="H" subId="17028706" subSource="8de4_A"/>
      <ConstraintRegion from="413" to="465" loc="O" subId="17028710" subSource="8de4_A"/>
      <ConstraintRegion from="466" to="483" loc="H" subId="17028713" subSource="8de4_A"/>
      <ConstraintRegion from="484" to="503" loc="I" subId="17028717" subSource="8de4_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028720" subSource="8de4_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028721" subSource="8de4_A"/>
      <ConstraintRegion from="526" to="546" loc="H" subId="17028722" subSource="8de4_A"/>
      <ConstraintRegion from="547" to="576" loc="I" subId="17028723" subSource="8de4_A"/>
      <ConstraintRegion from="577" to="598" loc="H" subId="17028725" subSource="8de4_A"/>
      <ConstraintRegion from="599" to="610" loc="O" subId="17028727" subSource="8de4_A"/>
      <ConstraintRegion from="611" to="625" loc="H" subId="17028729" subSource="8de4_A"/>
      <ConstraintRegion from="626" to="654" loc="I" subId="17028731" subSource="8de4_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
