<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="H7C5K9_HUMAN" transmembrane="yes" evidence="3D">
  <Name>ATP binding cassette subfamily B member 8 </Name>
  <CrossRef>
    <PDBTM id="3b5x">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7rit">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7met">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qex">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7v5d">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7vfi">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7o9w">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7a65">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7a6c">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7a6e">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7a6f">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7a69">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7v5c">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6qee">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6c0v">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5kpi">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4m2s">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4m2t">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5ko2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5kpd">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3g60">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3g61">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ksb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ksc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ksd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6gdi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6q81">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7oti">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4m1m">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5kpj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9j">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9k">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9l">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6fn1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6fn4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5koy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3g5u">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4lsg">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7otg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9h">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4xwk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9i">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zk9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zkb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zk8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zka">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8pee">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zk4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8avy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zk5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zk6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6lr0">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="7dv5">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="7e1a">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="5och">
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="A"/>
      <Chain id="H"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8pm6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7niw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7niu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6s7p">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7niv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q4j">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8pmd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3qf4">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q4h">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q4a">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ayx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6quz">
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4ayw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3zdq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ayt">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7y48">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6qv0">
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y49">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qv2">
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6qv1">
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8pmj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8t1p">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8fmv">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7m33">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8szc">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8fpf">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8fhk">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="3wmg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3wmf">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a6n">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a6m">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3wme">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7fc9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7dqv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8t3k">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7vr5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7sgr">
      <Chain id="I"/>
      <Chain id="A"/>
      <Chain id="E"/>
      <Chain id="J"/>
      <Chain id="B"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="8dck">
      <Chain id="A"/>
      <Chain id="I"/>
      <Chain id="E"/>
      <Chain id="B"/>
      <Chain id="J"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="4a82">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2hyd">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2onj">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ehl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5u1d">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5mkk">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rai">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ran">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rag">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ram">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6raf">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rak">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ral">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6raj">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rah">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zo8">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7zoa">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7znu">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7zo9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8k4b">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t54">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf6">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8k7a">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t56">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t55">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t57">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6v9z">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ry2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4s0f">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8chb">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ow8">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8woi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wom">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8woo">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wp0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8y6h">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8qoe">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7ocy">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="MDR1B_MOUSE">
      <Alignment>
        <CrossRefSeq>LVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAV</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1_CRIGR">
      <Alignment>
        <CrossRefSeq>FTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVL</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1_HUMAN">
      <Alignment>
        <CrossRefSeq>FTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVL</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1A_MOUSE">
      <Alignment>
        <CrossRefSeq>FTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVL</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ABCBB_HUMAN">
      <Alignment>
        <CrossRefSeq>FFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVI</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAG-QQLTGGDLMSFLVASQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HLYBP_ECOLX">
      <Alignment>
        <CrossRefSeq>MWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQI</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HLYB3_ECOLX">
      <Alignment>
        <CrossRefSeq>MWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQI</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TAP1_HUMAN">
      <Alignment>
        <CrossRefSeq>MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQ</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR65_DROME">
      <Alignment>
        <CrossRefSeq>FSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVA------GQQLTGGDLMSFLVASQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LMRA_LACLA">
      <Alignment>
        <CrossRefSeq>MLQMQWRLTLAMIIAVPVVMLIMFPIMTFGQKIGRTRQDSLANFQGIASESLSEIRLVKSSNAEKQASKKAENDVNALYKIGVKEAIFDGLMSPVMMLSMMLMIFGLLAYGIYLISTGVMSLGTLLGMMMYLMNL</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TAP1_RAT">
      <Alignment>
        <CrossRefSeq>MIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLYQLQFTR</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MSBA_FRAT1">
      <Alignment>
        <CrossRefSeq>MFVSSWQLSLFLIVVGPFLGLFISIINKKFRNLSRNTQSSMGNVTHTAEETIRNYKEIRIFGAQQKQQNKFFKNLDYTYSQQIRTIALDALTSPVIQIIASLVLAFSLF</CrossRefSeq>
        <OrigSeq>LSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="STE6_YEAST">
      <Alignment>
        <CrossRefSeq>FYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIML</CrossRefSeq>
        <OrigSeq>SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="140" CheckSum="a6036245e7cf235373171f76ff75070f">
    <Seq>
      XSLSMLSTRL TLLLMVATPA LMGVGTLMGS GLRKLSRQCQ EQIARAMGVA
      DEALGNVRTV RAFAMEQREE ERYGAELEAC RCRAEELGRG IALFQGLSNI
      AFNCMVLGTL FIGGSLVAGQ QLTGGDLMSF LVASQTVQRL 
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="89.19">
    <Region from="1" to="8" loc="O"/>
    <Region from="9" to="32" loc="M"/>
    <Region from="33" to="86" loc="I"/>
    <Region from="87" to="109" loc="M"/>
    <Region from="110" to="140" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="32" loc="M"/>
      <Region from="33" to="99" loc="I"/>
      <Region from="100" to="118" loc="M"/>
      <Region from="119" to="140" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="6" loc="O"/>
      <Region from="7" to="29" loc="M"/>
      <Region from="30" to="89" loc="I"/>
      <Region from="90" to="113" loc="M"/>
      <Region from="114" to="140" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="5" loc="O"/>
      <Region from="6" to="26" loc="M"/>
      <Region from="27" to="86" loc="I"/>
      <Region from="87" to="117" loc="M"/>
      <Region from="118" to="140" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="32" loc="M"/>
      <Region from="33" to="98" loc="I"/>
      <Region from="99" to="119" loc="M"/>
      <Region from="120" to="140" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="92" loc="I"/>
      <Region from="93" to="113" loc="M"/>
      <Region from="114" to="140" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="92" loc="I"/>
      <Region from="93" to="113" loc="M"/>
      <Region from="114" to="117" loc="O"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="7" loc="O"/>
      <Region from="8" to="27" loc="M"/>
      <Region from="28" to="140" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="7" loc="O"/>
      <Region from="8" to="28" loc="M"/>
      <Region from="29" to="91" loc="I"/>
      <Region from="92" to="112" loc="M"/>
      <Region from="113" to="140" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="32" loc="M"/>
      <Region from="33" to="99" loc="I"/>
      <Region from="100" to="122" loc="M"/>
      <Region from="123" to="140" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6qee_A">
      <ConstraintRegion from="31" to="44" loc="I" subId="17262130" subSource="6qee_A"/>
      <ConstraintRegion from="45" to="69" loc="H" subId="17262132" subSource="6qee_A"/>
      <ConstraintRegion from="70" to="116" loc="O" subId="17262134" subSource="6qee_A"/>
      <ConstraintRegion from="117" to="139" loc="H" subId="17262136" subSource="6qee_A"/>
      <ConstraintRegion from="140" to="185" loc="I" subId="17262138" subSource="6qee_A"/>
      <ConstraintRegion from="186" to="207" loc="H" subId="17262140" subSource="6qee_A"/>
      <ConstraintRegion from="208" to="214" loc="O" subId="17262142" subSource="6qee_A"/>
      <ConstraintRegion from="215" to="238" loc="H" subId="17262144" subSource="6qee_A"/>
      <ConstraintRegion from="239" to="289" loc="I" subId="17262146" subSource="6qee_A"/>
      <ConstraintRegion from="290" to="312" loc="H" subId="17262148" subSource="6qee_A"/>
      <ConstraintRegion from="313" to="332" loc="O" subId="17262150" subSource="6qee_A"/>
      <ConstraintRegion from="333" to="355" loc="H" subId="17262152" subSource="6qee_A"/>
      <ConstraintRegion from="356" to="629" loc="I" subId="17262153" subSource="6qee_A"/>
      <ConstraintRegion from="693" to="695" loc="I" subId="17262155" subSource="6qee_A"/>
      <ConstraintRegion from="696" to="703" loc="F" subId="17262157" subSource="6qee_A"/>
      <ConstraintRegion from="704" to="706" loc="I" subId="17262158" subSource="6qee_A"/>
      <ConstraintRegion from="707" to="731" loc="H" subId="17262159" subSource="6qee_A"/>
      <ConstraintRegion from="732" to="755" loc="O" subId="17262161" subSource="6qee_A"/>
      <ConstraintRegion from="756" to="779" loc="H" subId="17262163" subSource="6qee_A"/>
      <ConstraintRegion from="780" to="827" loc="I" subId="17262165" subSource="6qee_A"/>
      <ConstraintRegion from="828" to="850" loc="H" subId="17262166" subSource="6qee_A"/>
      <ConstraintRegion from="851" to="856" loc="O" subId="17262167" subSource="6qee_A"/>
      <ConstraintRegion from="857" to="881" loc="H" subId="17262169" subSource="6qee_A"/>
      <ConstraintRegion from="882" to="931" loc="I" subId="17262171" subSource="6qee_A"/>
      <ConstraintRegion from="932" to="955" loc="H" subId="17262173" subSource="6qee_A"/>
      <ConstraintRegion from="956" to="975" loc="O" subId="17262174" subSource="6qee_A"/>
      <ConstraintRegion from="976" to="997" loc="H" subId="17262175" subSource="6qee_A"/>
      <ConstraintRegion from="998" to="1275" loc="I" subId="17262177" subSource="6qee_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3wmg_A">
      <ConstraintRegion from="102" to="102" loc="I" subId="17399872" subSource="3wmg_A"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="17399874" subSource="3wmg_A"/>
      <ConstraintRegion from="117" to="118" loc="I" subId="17399876" subSource="3wmg_A"/>
      <ConstraintRegion from="119" to="142" loc="H" subId="17399878" subSource="3wmg_A"/>
      <ConstraintRegion from="143" to="163" loc="O" subId="17399880" subSource="3wmg_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17399882" subSource="3wmg_A"/>
      <ConstraintRegion from="187" to="236" loc="I" subId="17399884" subSource="3wmg_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17399886" subSource="3wmg_A"/>
      <ConstraintRegion from="256" to="266" loc="O" subId="17399888" subSource="3wmg_A"/>
      <ConstraintRegion from="267" to="287" loc="H" subId="17399890" subSource="3wmg_A"/>
      <ConstraintRegion from="288" to="334" loc="I" subId="17399892" subSource="3wmg_A"/>
      <ConstraintRegion from="335" to="358" loc="H" subId="17399894" subSource="3wmg_A"/>
      <ConstraintRegion from="359" to="383" loc="O" subId="17399896" subSource="3wmg_A"/>
      <ConstraintRegion from="384" to="404" loc="H" subId="17399898" subSource="3wmg_A"/>
      <ConstraintRegion from="405" to="690" loc="I" subId="17399901" subSource="3wmg_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6a6n_A">
      <ConstraintRegion from="102" to="102" loc="I" subId="16963838" subSource="6a6n_A"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="16963839" subSource="6a6n_A"/>
      <ConstraintRegion from="117" to="117" loc="I" subId="16963840" subSource="6a6n_A"/>
      <ConstraintRegion from="118" to="142" loc="H" subId="16963841" subSource="6a6n_A"/>
      <ConstraintRegion from="143" to="165" loc="O" subId="16963842" subSource="6a6n_A"/>
      <ConstraintRegion from="166" to="188" loc="H" subId="16963843" subSource="6a6n_A"/>
      <ConstraintRegion from="189" to="235" loc="I" subId="16963844" subSource="6a6n_A"/>
      <ConstraintRegion from="236" to="256" loc="H" subId="16963845" subSource="6a6n_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="16963846" subSource="6a6n_A"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="16963847" subSource="6a6n_A"/>
      <ConstraintRegion from="285" to="337" loc="I" subId="16963848" subSource="6a6n_A"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="16963849" subSource="6a6n_A"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="16963850" subSource="6a6n_A"/>
      <ConstraintRegion from="382" to="403" loc="H" subId="16963851" subSource="6a6n_A"/>
      <ConstraintRegion from="404" to="688" loc="I" subId="16963852" subSource="6a6n_A"/>
      <ConstraintRegion from="102" to="102" loc="I" subId="16963853" subSource="6a6n_B"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="16963854" subSource="6a6n_B"/>
      <ConstraintRegion from="117" to="117" loc="I" subId="16963855" subSource="6a6n_B"/>
      <ConstraintRegion from="118" to="142" loc="H" subId="16963856" subSource="6a6n_B"/>
      <ConstraintRegion from="143" to="165" loc="O" subId="16963857" subSource="6a6n_B"/>
      <ConstraintRegion from="166" to="188" loc="H" subId="16963858" subSource="6a6n_B"/>
      <ConstraintRegion from="189" to="235" loc="I" subId="16963859" subSource="6a6n_B"/>
      <ConstraintRegion from="236" to="256" loc="H" subId="16963860" subSource="6a6n_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="16963861" subSource="6a6n_B"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="16963862" subSource="6a6n_B"/>
      <ConstraintRegion from="285" to="337" loc="I" subId="16963863" subSource="6a6n_B"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="16963864" subSource="6a6n_B"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="16963865" subSource="6a6n_B"/>
      <ConstraintRegion from="382" to="403" loc="H" subId="16963866" subSource="6a6n_B"/>
      <ConstraintRegion from="404" to="688" loc="I" subId="16963867" subSource="6a6n_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7dqv_A">
      <ConstraintRegion from="101" to="101" loc="I" subId="17036392" subSource="7dqv_A"/>
      <ConstraintRegion from="102" to="117" loc="F" subId="17036394" subSource="7dqv_A"/>
      <ConstraintRegion from="118" to="139" loc="H" subId="17036396" subSource="7dqv_A"/>
      <ConstraintRegion from="140" to="165" loc="O" subId="17036398" subSource="7dqv_A"/>
      <ConstraintRegion from="166" to="189" loc="H" subId="17036400" subSource="7dqv_A"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17036402" subSource="7dqv_A"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17036404" subSource="7dqv_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17036406" subSource="7dqv_A"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="17036408" subSource="7dqv_A"/>
      <ConstraintRegion from="285" to="338" loc="I" subId="17036410" subSource="7dqv_A"/>
      <ConstraintRegion from="339" to="361" loc="H" subId="17036412" subSource="7dqv_A"/>
      <ConstraintRegion from="362" to="382" loc="O" subId="17036414" subSource="7dqv_A"/>
      <ConstraintRegion from="383" to="405" loc="H" subId="17036416" subSource="7dqv_A"/>
      <ConstraintRegion from="406" to="689" loc="I" subId="17036418" subSource="7dqv_A"/>
      <ConstraintRegion from="101" to="101" loc="I" subId="17036422" subSource="7dqv_B"/>
      <ConstraintRegion from="102" to="117" loc="F" subId="17036424" subSource="7dqv_B"/>
      <ConstraintRegion from="118" to="139" loc="H" subId="17036426" subSource="7dqv_B"/>
      <ConstraintRegion from="140" to="165" loc="O" subId="17036429" subSource="7dqv_B"/>
      <ConstraintRegion from="166" to="189" loc="H" subId="17036430" subSource="7dqv_B"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17036432" subSource="7dqv_B"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17036434" subSource="7dqv_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17036437" subSource="7dqv_B"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="17036439" subSource="7dqv_B"/>
      <ConstraintRegion from="285" to="338" loc="I" subId="17036441" subSource="7dqv_B"/>
      <ConstraintRegion from="339" to="361" loc="H" subId="17036443" subSource="7dqv_B"/>
      <ConstraintRegion from="362" to="382" loc="O" subId="17036446" subSource="7dqv_B"/>
      <ConstraintRegion from="383" to="405" loc="H" subId="17036448" subSource="7dqv_B"/>
      <ConstraintRegion from="406" to="689" loc="I" subId="17036450" subSource="7dqv_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7vr5_A">
      <ConstraintRegion from="101" to="117" loc="I" subId="17369768" subSource="7vr5_A"/>
      <ConstraintRegion from="118" to="140" loc="H" subId="17369770" subSource="7vr5_A"/>
      <ConstraintRegion from="141" to="166" loc="O" subId="17369773" subSource="7vr5_A"/>
      <ConstraintRegion from="167" to="189" loc="H" subId="17369776" subSource="7vr5_A"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17369778" subSource="7vr5_A"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17369782" subSource="7vr5_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17369785" subSource="7vr5_A"/>
      <ConstraintRegion from="264" to="285" loc="H" subId="17369788" subSource="7vr5_A"/>
      <ConstraintRegion from="286" to="337" loc="I" subId="17369790" subSource="7vr5_A"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="17369792" subSource="7vr5_A"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="17369795" subSource="7vr5_A"/>
      <ConstraintRegion from="382" to="404" loc="H" subId="17369798" subSource="7vr5_A"/>
      <ConstraintRegion from="405" to="688" loc="I" subId="17369801" subSource="7vr5_A"/>
      <ConstraintRegion from="101" to="117" loc="I" subId="17369812" subSource="7vr5_B"/>
      <ConstraintRegion from="118" to="140" loc="H" subId="17369814" subSource="7vr5_B"/>
      <ConstraintRegion from="141" to="166" loc="O" subId="17369817" subSource="7vr5_B"/>
      <ConstraintRegion from="167" to="189" loc="H" subId="17369821" subSource="7vr5_B"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17369824" subSource="7vr5_B"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17369826" subSource="7vr5_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17369828" subSource="7vr5_B"/>
      <ConstraintRegion from="264" to="285" loc="H" subId="17369830" subSource="7vr5_B"/>
      <ConstraintRegion from="286" to="337" loc="I" subId="17369831" subSource="7vr5_B"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="17369833" subSource="7vr5_B"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="17369835" subSource="7vr5_B"/>
      <ConstraintRegion from="382" to="404" loc="H" subId="17369838" subSource="7vr5_B"/>
      <ConstraintRegion from="405" to="688" loc="I" subId="17369841" subSource="7vr5_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="Y2003_STAA8">
      <ConstraintRegion from="1" to="19" loc="I" subId="16964279" subSource="4a82_A"/>
      <ConstraintRegion from="20" to="34" loc="H" subId="16964280" subSource="4a82_A"/>
      <ConstraintRegion from="35" to="62" loc="O" subId="16964281" subSource="4a82_A"/>
      <ConstraintRegion from="63" to="78" loc="H" subId="16964282" subSource="4a82_A"/>
      <ConstraintRegion from="79" to="141" loc="I" subId="16964283" subSource="4a82_A"/>
      <ConstraintRegion from="142" to="156" loc="H" subId="16964284" subSource="4a82_A"/>
      <ConstraintRegion from="157" to="163" loc="O" subId="16964285" subSource="4a82_A"/>
      <ConstraintRegion from="164" to="177" loc="H" subId="16964286" subSource="4a82_A"/>
      <ConstraintRegion from="178" to="247" loc="I" subId="16964287" subSource="4a82_A"/>
      <ConstraintRegion from="248" to="261" loc="H" subId="16964288" subSource="4a82_A"/>
      <ConstraintRegion from="262" to="285" loc="O" subId="16964289" subSource="4a82_A"/>
      <ConstraintRegion from="286" to="298" loc="H" subId="16964290" subSource="4a82_A"/>
      <ConstraintRegion from="299" to="578" loc="I" subId="16964291" subSource="4a82_A"/>
      <ConstraintRegion from="1" to="16" loc="I" subId="16964292" subSource="4a82_B"/>
      <ConstraintRegion from="17" to="33" loc="H" subId="16964293" subSource="4a82_B"/>
      <ConstraintRegion from="34" to="65" loc="O" subId="16964294" subSource="4a82_B"/>
      <ConstraintRegion from="66" to="81" loc="H" subId="16964295" subSource="4a82_B"/>
      <ConstraintRegion from="82" to="140" loc="I" subId="16964296" subSource="4a82_B"/>
      <ConstraintRegion from="141" to="154" loc="H" subId="16964297" subSource="4a82_B"/>
      <ConstraintRegion from="155" to="163" loc="O" subId="16964298" subSource="4a82_B"/>
      <ConstraintRegion from="164" to="177" loc="H" subId="16964299" subSource="4a82_B"/>
      <ConstraintRegion from="178" to="248" loc="I" subId="16964300" subSource="4a82_B"/>
      <ConstraintRegion from="249" to="262" loc="H" subId="16964301" subSource="4a82_B"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="16964302" subSource="4a82_B"/>
      <ConstraintRegion from="286" to="298" loc="H" subId="16964303" subSource="4a82_B"/>
      <ConstraintRegion from="299" to="578" loc="I" subId="16964304" subSource="4a82_B"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17114821" subSource="2hyd_A"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17114823" subSource="2hyd_A"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17114825" subSource="2hyd_A"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17114827" subSource="2hyd_A"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17114829" subSource="2hyd_A"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17114832" subSource="2hyd_A"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17114834" subSource="2hyd_A"/>
      <ConstraintRegion from="158" to="163" loc="O" subId="17114837" subSource="2hyd_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17114839" subSource="2hyd_A"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17114841" subSource="2hyd_A"/>
      <ConstraintRegion from="241" to="262" loc="H" subId="17114842" subSource="2hyd_A"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="17114845" subSource="2hyd_A"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17114847" subSource="2hyd_A"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17114850" subSource="2hyd_A"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17114855" subSource="2hyd_B"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17114857" subSource="2hyd_B"/>
      <ConstraintRegion from="10" to="34" loc="H" subId="17114859" subSource="2hyd_B"/>
      <ConstraintRegion from="35" to="63" loc="O" subId="17114862" subSource="2hyd_B"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17114864" subSource="2hyd_B"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17114866" subSource="2hyd_B"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17114869" subSource="2hyd_B"/>
      <ConstraintRegion from="158" to="164" loc="O" subId="17114871" subSource="2hyd_B"/>
      <ConstraintRegion from="165" to="186" loc="H" subId="17114873" subSource="2hyd_B"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17114875" subSource="2hyd_B"/>
      <ConstraintRegion from="241" to="263" loc="H" subId="17114877" subSource="2hyd_B"/>
      <ConstraintRegion from="264" to="285" loc="O" subId="17114879" subSource="2hyd_B"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17114881" subSource="2hyd_B"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17114883" subSource="2hyd_B"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17230901" subSource="2onj_A"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17230902" subSource="2onj_A"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17230904" subSource="2onj_A"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17230906" subSource="2onj_A"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17230908" subSource="2onj_A"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17230910" subSource="2onj_A"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17230912" subSource="2onj_A"/>
      <ConstraintRegion from="158" to="163" loc="O" subId="17230914" subSource="2onj_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17230916" subSource="2onj_A"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17230918" subSource="2onj_A"/>
      <ConstraintRegion from="241" to="262" loc="H" subId="17230921" subSource="2onj_A"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="17230924" subSource="2onj_A"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17230927" subSource="2onj_A"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17230930" subSource="2onj_A"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17230935" subSource="2onj_B"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17230938" subSource="2onj_B"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17230940" subSource="2onj_B"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17230942" subSource="2onj_B"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17230945" subSource="2onj_B"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17230948" subSource="2onj_B"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17230950" subSource="2onj_B"/>
      <ConstraintRegion from="158" to="164" loc="O" subId="17230953" subSource="2onj_B"/>
      <ConstraintRegion from="165" to="186" loc="H" subId="17230956" subSource="2onj_B"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17230958" subSource="2onj_B"/>
      <ConstraintRegion from="241" to="263" loc="H" subId="17230961" subSource="2onj_B"/>
      <ConstraintRegion from="264" to="285" loc="O" subId="17230964" subSource="2onj_B"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17230966" subSource="2onj_B"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17230969" subSource="2onj_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6quz_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="17270724" subSource="6quz_A"/>
      <ConstraintRegion from="14" to="36" loc="H" subId="17270726" subSource="6quz_A"/>
      <ConstraintRegion from="37" to="55" loc="O" subId="17270728" subSource="6quz_A"/>
      <ConstraintRegion from="56" to="77" loc="H" subId="17270729" subSource="6quz_A"/>
      <ConstraintRegion from="78" to="128" loc="I" subId="17270730" subSource="6quz_A"/>
      <ConstraintRegion from="129" to="149" loc="H" subId="17270732" subSource="6quz_A"/>
      <ConstraintRegion from="150" to="156" loc="O" subId="17270734" subSource="6quz_A"/>
      <ConstraintRegion from="157" to="174" loc="H" subId="17270736" subSource="6quz_A"/>
      <ConstraintRegion from="175" to="234" loc="I" subId="17270738" subSource="6quz_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17270740" subSource="6quz_A"/>
      <ConstraintRegion from="255" to="275" loc="O" subId="17270742" subSource="6quz_A"/>
      <ConstraintRegion from="276" to="295" loc="H" subId="17270744" subSource="6quz_A"/>
      <ConstraintRegion from="296" to="569" loc="I" subId="17270746" subSource="6quz_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6qv1_A">
      <ConstraintRegion from="2" to="12" loc="I" subId="17270767" subSource="6qv1_A"/>
      <ConstraintRegion from="13" to="36" loc="H" subId="17270768" subSource="6qv1_A"/>
      <ConstraintRegion from="37" to="53" loc="O" subId="17270769" subSource="6qv1_A"/>
      <ConstraintRegion from="54" to="78" loc="H" subId="17270770" subSource="6qv1_A"/>
      <ConstraintRegion from="79" to="126" loc="I" subId="17270771" subSource="6qv1_A"/>
      <ConstraintRegion from="127" to="149" loc="H" subId="17270772" subSource="6qv1_A"/>
      <ConstraintRegion from="150" to="155" loc="O" subId="17270773" subSource="6qv1_A"/>
      <ConstraintRegion from="156" to="177" loc="H" subId="17270774" subSource="6qv1_A"/>
      <ConstraintRegion from="178" to="233" loc="I" subId="17270775" subSource="6qv1_A"/>
      <ConstraintRegion from="234" to="254" loc="H" subId="17270776" subSource="6qv1_A"/>
      <ConstraintRegion from="255" to="275" loc="O" subId="17270777" subSource="6qv1_A"/>
      <ConstraintRegion from="276" to="297" loc="H" subId="17270778" subSource="6qv1_A"/>
      <ConstraintRegion from="298" to="570" loc="I" subId="17270779" subSource="6qv1_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6qv0_A">
      <ConstraintRegion from="2" to="2" loc="I" subId="17270711" subSource="6qv0_A"/>
      <ConstraintRegion from="3" to="9" loc="F" subId="17270712" subSource="6qv0_A"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17270713" subSource="6qv0_A"/>
      <ConstraintRegion from="13" to="33" loc="H" subId="17270714" subSource="6qv0_A"/>
      <ConstraintRegion from="34" to="56" loc="O" subId="17270715" subSource="6qv0_A"/>
      <ConstraintRegion from="57" to="79" loc="H" subId="17270716" subSource="6qv0_A"/>
      <ConstraintRegion from="80" to="126" loc="I" subId="17270717" subSource="6qv0_A"/>
      <ConstraintRegion from="127" to="149" loc="H" subId="17270718" subSource="6qv0_A"/>
      <ConstraintRegion from="150" to="156" loc="O" subId="17270719" subSource="6qv0_A"/>
      <ConstraintRegion from="157" to="175" loc="H" subId="17270720" subSource="6qv0_A"/>
      <ConstraintRegion from="176" to="234" loc="I" subId="17270721" subSource="6qv0_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17270722" subSource="6qv0_A"/>
      <ConstraintRegion from="255" to="276" loc="O" subId="17270723" subSource="6qv0_A"/>
      <ConstraintRegion from="277" to="296" loc="H" subId="17270725" subSource="6qv0_A"/>
      <ConstraintRegion from="297" to="569" loc="I" subId="17270727" subSource="6qv0_A"/>
      <ConstraintRegion from="2" to="11" loc="I" subId="17270795" subSource="6qv2_A"/>
      <ConstraintRegion from="12" to="33" loc="H" subId="17270796" subSource="6qv2_A"/>
      <ConstraintRegion from="34" to="57" loc="O" subId="17270797" subSource="6qv2_A"/>
      <ConstraintRegion from="58" to="81" loc="H" subId="17270798" subSource="6qv2_A"/>
      <ConstraintRegion from="82" to="125" loc="I" subId="17270799" subSource="6qv2_A"/>
      <ConstraintRegion from="126" to="149" loc="H" subId="17270800" subSource="6qv2_A"/>
      <ConstraintRegion from="150" to="156" loc="O" subId="17270801" subSource="6qv2_A"/>
      <ConstraintRegion from="157" to="175" loc="H" subId="17270802" subSource="6qv2_A"/>
      <ConstraintRegion from="176" to="234" loc="I" subId="17270803" subSource="6qv2_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17270804" subSource="6qv2_A"/>
      <ConstraintRegion from="255" to="275" loc="O" subId="17270805" subSource="6qv2_A"/>
      <ConstraintRegion from="276" to="297" loc="H" subId="17270806" subSource="6qv2_A"/>
      <ConstraintRegion from="298" to="569" loc="I" subId="17270807" subSource="6qv2_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4q4j_A">
      <ConstraintRegion from="-2" to="12" loc="I" subId="17258895" subSource="4q4j_A"/>
      <ConstraintRegion from="13" to="35" loc="H" subId="17258899" subSource="4q4j_A"/>
      <ConstraintRegion from="36" to="57" loc="O" subId="17258901" subSource="4q4j_A"/>
      <ConstraintRegion from="58" to="78" loc="H" subId="17258903" subSource="4q4j_A"/>
      <ConstraintRegion from="79" to="128" loc="I" subId="17258905" subSource="4q4j_A"/>
      <ConstraintRegion from="129" to="150" loc="H" subId="17258907" subSource="4q4j_A"/>
      <ConstraintRegion from="151" to="156" loc="O" subId="17258908" subSource="4q4j_A"/>
      <ConstraintRegion from="157" to="177" loc="H" subId="17258909" subSource="4q4j_A"/>
      <ConstraintRegion from="178" to="230" loc="I" subId="17258910" subSource="4q4j_A"/>
      <ConstraintRegion from="231" to="254" loc="H" subId="17258912" subSource="4q4j_A"/>
      <ConstraintRegion from="255" to="274" loc="O" subId="17258914" subSource="4q4j_A"/>
      <ConstraintRegion from="275" to="295" loc="H" subId="17258916" subSource="4q4j_A"/>
      <ConstraintRegion from="296" to="569" loc="I" subId="17258918" subSource="4q4j_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rai_B">
      <ConstraintRegion from="3" to="6" loc="I" subId="17278127" subSource="6rai_B"/>
      <ConstraintRegion from="7" to="20" loc="F" subId="17278128" subSource="6rai_B"/>
      <ConstraintRegion from="21" to="25" loc="I" subId="17278130" subSource="6rai_B"/>
      <ConstraintRegion from="26" to="44" loc="H" subId="17278132" subSource="6rai_B"/>
      <ConstraintRegion from="45" to="62" loc="O" subId="17278133" subSource="6rai_B"/>
      <ConstraintRegion from="63" to="80" loc="H" subId="17278135" subSource="6rai_B"/>
      <ConstraintRegion from="81" to="137" loc="I" subId="17278137" subSource="6rai_B"/>
      <ConstraintRegion from="138" to="155" loc="H" subId="17278138" subSource="6rai_B"/>
      <ConstraintRegion from="156" to="162" loc="O" subId="17278140" subSource="6rai_B"/>
      <ConstraintRegion from="163" to="179" loc="H" subId="17278142" subSource="6rai_B"/>
      <ConstraintRegion from="180" to="241" loc="I" subId="17278143" subSource="6rai_B"/>
      <ConstraintRegion from="242" to="259" loc="H" subId="17278144" subSource="6rai_B"/>
      <ConstraintRegion from="260" to="281" loc="O" subId="17278146" subSource="6rai_B"/>
      <ConstraintRegion from="282" to="299" loc="H" subId="17278148" subSource="6rai_B"/>
      <ConstraintRegion from="300" to="575" loc="I" subId="17278149" subSource="6rai_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ran_B">
      <ConstraintRegion from="4" to="5" loc="I" subId="17279086" subSource="6ran_B"/>
      <ConstraintRegion from="6" to="18" loc="F" subId="17279087" subSource="6ran_B"/>
      <ConstraintRegion from="19" to="21" loc="I" subId="17279088" subSource="6ran_B"/>
      <ConstraintRegion from="22" to="42" loc="H" subId="17279089" subSource="6ran_B"/>
      <ConstraintRegion from="43" to="65" loc="O" subId="17279090" subSource="6ran_B"/>
      <ConstraintRegion from="66" to="84" loc="H" subId="17279091" subSource="6ran_B"/>
      <ConstraintRegion from="85" to="135" loc="I" subId="17279092" subSource="6ran_B"/>
      <ConstraintRegion from="136" to="153" loc="H" subId="17279093" subSource="6ran_B"/>
      <ConstraintRegion from="154" to="163" loc="O" subId="17279094" subSource="6ran_B"/>
      <ConstraintRegion from="164" to="180" loc="H" subId="17279095" subSource="6ran_B"/>
      <ConstraintRegion from="181" to="243" loc="I" subId="17279096" subSource="6ran_B"/>
      <ConstraintRegion from="244" to="259" loc="H" subId="17279097" subSource="6ran_B"/>
      <ConstraintRegion from="260" to="282" loc="O" subId="17279098" subSource="6ran_B"/>
      <ConstraintRegion from="283" to="299" loc="H" subId="17279099" subSource="6ran_B"/>
      <ConstraintRegion from="300" to="577" loc="I" subId="17279100" subSource="6ran_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rag_B">
      <ConstraintRegion from="4" to="5" loc="I" subId="17277802" subSource="6rag_B"/>
      <ConstraintRegion from="6" to="21" loc="F" subId="17277803" subSource="6rag_B"/>
      <ConstraintRegion from="22" to="45" loc="H" subId="17277804" subSource="6rag_B"/>
      <ConstraintRegion from="46" to="62" loc="O" subId="17277805" subSource="6rag_B"/>
      <ConstraintRegion from="63" to="84" loc="H" subId="17277806" subSource="6rag_B"/>
      <ConstraintRegion from="85" to="135" loc="I" subId="17277807" subSource="6rag_B"/>
      <ConstraintRegion from="136" to="155" loc="H" subId="17277808" subSource="6rag_B"/>
      <ConstraintRegion from="156" to="162" loc="O" subId="17277809" subSource="6rag_B"/>
      <ConstraintRegion from="163" to="181" loc="H" subId="17277810" subSource="6rag_B"/>
      <ConstraintRegion from="182" to="241" loc="I" subId="17277811" subSource="6rag_B"/>
      <ConstraintRegion from="242" to="261" loc="H" subId="17277812" subSource="6rag_B"/>
      <ConstraintRegion from="262" to="279" loc="O" subId="17277813" subSource="6rag_B"/>
      <ConstraintRegion from="280" to="299" loc="H" subId="17277814" subSource="6rag_B"/>
      <ConstraintRegion from="300" to="578" loc="I" subId="17277815" subSource="6rag_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ram_B">
      <ConstraintRegion from="4" to="6" loc="I" subId="17278974" subSource="6ram_B"/>
      <ConstraintRegion from="7" to="14" loc="F" subId="17278976" subSource="6ram_B"/>
      <ConstraintRegion from="15" to="22" loc="I" subId="17278978" subSource="6ram_B"/>
      <ConstraintRegion from="23" to="43" loc="H" subId="17278980" subSource="6ram_B"/>
      <ConstraintRegion from="44" to="64" loc="O" subId="17278982" subSource="6ram_B"/>
      <ConstraintRegion from="65" to="84" loc="H" subId="17278984" subSource="6ram_B"/>
      <ConstraintRegion from="85" to="135" loc="I" subId="17278987" subSource="6ram_B"/>
      <ConstraintRegion from="136" to="155" loc="H" subId="17278988" subSource="6ram_B"/>
      <ConstraintRegion from="156" to="161" loc="O" subId="17278989" subSource="6ram_B"/>
      <ConstraintRegion from="162" to="180" loc="H" subId="17278991" subSource="6ram_B"/>
      <ConstraintRegion from="181" to="241" loc="I" subId="17278993" subSource="6ram_B"/>
      <ConstraintRegion from="242" to="261" loc="H" subId="17278995" subSource="6ram_B"/>
      <ConstraintRegion from="262" to="280" loc="O" subId="17278997" subSource="6ram_B"/>
      <ConstraintRegion from="281" to="299" loc="H" subId="17278999" subSource="6ram_B"/>
      <ConstraintRegion from="300" to="575" loc="I" subId="17279001" subSource="6ram_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6raf_B">
      <ConstraintRegion from="5" to="21" loc="I" subId="17277643" subSource="6raf_B"/>
      <ConstraintRegion from="22" to="42" loc="H" subId="17277646" subSource="6raf_B"/>
      <ConstraintRegion from="43" to="64" loc="O" subId="17277648" subSource="6raf_B"/>
      <ConstraintRegion from="65" to="86" loc="H" subId="17277651" subSource="6raf_B"/>
      <ConstraintRegion from="87" to="132" loc="I" subId="17277654" subSource="6raf_B"/>
      <ConstraintRegion from="133" to="156" loc="H" subId="17277658" subSource="6raf_B"/>
      <ConstraintRegion from="157" to="162" loc="O" subId="17277660" subSource="6raf_B"/>
      <ConstraintRegion from="163" to="186" loc="H" subId="17277664" subSource="6raf_B"/>
      <ConstraintRegion from="187" to="235" loc="I" subId="17277668" subSource="6raf_B"/>
      <ConstraintRegion from="236" to="258" loc="H" subId="17277672" subSource="6raf_B"/>
      <ConstraintRegion from="259" to="281" loc="O" subId="17277676" subSource="6raf_B"/>
      <ConstraintRegion from="282" to="303" loc="H" subId="17277679" subSource="6raf_B"/>
      <ConstraintRegion from="304" to="575" loc="I" subId="17277682" subSource="6raf_B"/>
      <ConstraintRegion from="5" to="25" loc="I" subId="17278540" subSource="6rak_B"/>
      <ConstraintRegion from="26" to="42" loc="H" subId="17278542" subSource="6rak_B"/>
      <ConstraintRegion from="43" to="65" loc="O" subId="17278544" subSource="6rak_B"/>
      <ConstraintRegion from="66" to="80" loc="H" subId="17278548" subSource="6rak_B"/>
      <ConstraintRegion from="81" to="138" loc="I" subId="17278551" subSource="6rak_B"/>
      <ConstraintRegion from="139" to="155" loc="H" subId="17278554" subSource="6rak_B"/>
      <ConstraintRegion from="156" to="161" loc="O" subId="17278556" subSource="6rak_B"/>
      <ConstraintRegion from="162" to="175" loc="H" subId="17278558" subSource="6rak_B"/>
      <ConstraintRegion from="176" to="244" loc="I" subId="17278562" subSource="6rak_B"/>
      <ConstraintRegion from="245" to="260" loc="H" subId="17278565" subSource="6rak_B"/>
      <ConstraintRegion from="261" to="281" loc="O" subId="17278568" subSource="6rak_B"/>
      <ConstraintRegion from="282" to="296" loc="H" subId="17278571" subSource="6rak_B"/>
      <ConstraintRegion from="297" to="575" loc="I" subId="17278575" subSource="6rak_B"/>
      <ConstraintRegion from="5" to="13" loc="I" subId="17278766" subSource="6ral_B"/>
      <ConstraintRegion from="14" to="21" loc="F" subId="17278768" subSource="6ral_B"/>
      <ConstraintRegion from="22" to="42" loc="H" subId="17278770" subSource="6ral_B"/>
      <ConstraintRegion from="43" to="63" loc="O" subId="17278772" subSource="6ral_B"/>
      <ConstraintRegion from="64" to="84" loc="H" subId="17278774" subSource="6ral_B"/>
      <ConstraintRegion from="85" to="134" loc="I" subId="17278775" subSource="6ral_B"/>
      <ConstraintRegion from="135" to="154" loc="H" subId="17278778" subSource="6ral_B"/>
      <ConstraintRegion from="155" to="163" loc="O" subId="17278780" subSource="6ral_B"/>
      <ConstraintRegion from="164" to="183" loc="H" subId="17278782" subSource="6ral_B"/>
      <ConstraintRegion from="184" to="239" loc="I" subId="17278783" subSource="6ral_B"/>
      <ConstraintRegion from="240" to="258" loc="H" subId="17278786" subSource="6ral_B"/>
      <ConstraintRegion from="259" to="282" loc="O" subId="17278788" subSource="6ral_B"/>
      <ConstraintRegion from="283" to="302" loc="H" subId="17278790" subSource="6ral_B"/>
      <ConstraintRegion from="303" to="575" loc="I" subId="17278791" subSource="6ral_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6raj_B">
      <ConstraintRegion from="4" to="6" loc="I" subId="17278345" subSource="6raj_B"/>
      <ConstraintRegion from="7" to="20" loc="F" subId="17278349" subSource="6raj_B"/>
      <ConstraintRegion from="21" to="22" loc="I" subId="17278353" subSource="6raj_B"/>
      <ConstraintRegion from="23" to="42" loc="H" subId="17278356" subSource="6raj_B"/>
      <ConstraintRegion from="43" to="63" loc="O" subId="17278358" subSource="6raj_B"/>
      <ConstraintRegion from="64" to="83" loc="H" subId="17278363" subSource="6raj_B"/>
      <ConstraintRegion from="84" to="135" loc="I" subId="17278365" subSource="6raj_B"/>
      <ConstraintRegion from="136" to="155" loc="H" subId="17278368" subSource="6raj_B"/>
      <ConstraintRegion from="156" to="159" loc="O" subId="17278372" subSource="6raj_B"/>
      <ConstraintRegion from="160" to="180" loc="H" subId="17278376" subSource="6raj_B"/>
      <ConstraintRegion from="181" to="239" loc="I" subId="17278380" subSource="6raj_B"/>
      <ConstraintRegion from="240" to="260" loc="H" subId="17278384" subSource="6raj_B"/>
      <ConstraintRegion from="261" to="283" loc="O" subId="17278388" subSource="6raj_B"/>
      <ConstraintRegion from="284" to="302" loc="H" subId="17278390" subSource="6raj_B"/>
      <ConstraintRegion from="303" to="576" loc="I" subId="17278393" subSource="6raj_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rah_B">
      <ConstraintRegion from="5" to="5" loc="I" subId="17277972" subSource="6rah_B"/>
      <ConstraintRegion from="6" to="18" loc="F" subId="17277974" subSource="6rah_B"/>
      <ConstraintRegion from="19" to="21" loc="I" subId="17277976" subSource="6rah_B"/>
      <ConstraintRegion from="22" to="41" loc="H" subId="17277978" subSource="6rah_B"/>
      <ConstraintRegion from="42" to="65" loc="O" subId="17277980" subSource="6rah_B"/>
      <ConstraintRegion from="66" to="84" loc="H" subId="17277981" subSource="6rah_B"/>
      <ConstraintRegion from="85" to="135" loc="I" subId="17277983" subSource="6rah_B"/>
      <ConstraintRegion from="136" to="155" loc="H" subId="17277985" subSource="6rah_B"/>
      <ConstraintRegion from="156" to="159" loc="O" subId="17277987" subSource="6rah_B"/>
      <ConstraintRegion from="160" to="177" loc="H" subId="17277989" subSource="6rah_B"/>
      <ConstraintRegion from="178" to="243" loc="I" subId="17277991" subSource="6rah_B"/>
      <ConstraintRegion from="244" to="263" loc="H" subId="17277993" subSource="6rah_B"/>
      <ConstraintRegion from="264" to="282" loc="O" subId="17277995" subSource="6rah_B"/>
      <ConstraintRegion from="283" to="299" loc="H" subId="17277997" subSource="6rah_B"/>
      <ConstraintRegion from="300" to="574" loc="I" subId="17277999" subSource="6rah_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ral_A">
      <ConstraintRegion from="11" to="13" loc="I" subId="17278739" subSource="6ral_A"/>
      <ConstraintRegion from="14" to="26" loc="F" subId="17278740" subSource="6ral_A"/>
      <ConstraintRegion from="27" to="47" loc="H" subId="17278741" subSource="6ral_A"/>
      <ConstraintRegion from="48" to="80" loc="O" subId="17278743" subSource="6ral_A"/>
      <ConstraintRegion from="81" to="100" loc="H" subId="17278745" subSource="6ral_A"/>
      <ConstraintRegion from="101" to="148" loc="I" subId="17278747" subSource="6ral_A"/>
      <ConstraintRegion from="149" to="171" loc="H" subId="17278748" subSource="6ral_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17278750" subSource="6ral_A"/>
      <ConstraintRegion from="178" to="195" loc="H" subId="17278752" subSource="6ral_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17278754" subSource="6ral_A"/>
      <ConstraintRegion from="256" to="275" loc="H" subId="17278756" subSource="6ral_A"/>
      <ConstraintRegion from="276" to="296" loc="O" subId="17278758" subSource="6ral_A"/>
      <ConstraintRegion from="297" to="314" loc="H" subId="17278760" subSource="6ral_A"/>
      <ConstraintRegion from="315" to="593" loc="I" subId="17278763" subSource="6ral_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rag_A">
      <ConstraintRegion from="11" to="30" loc="I" subId="17277789" subSource="6rag_A"/>
      <ConstraintRegion from="31" to="50" loc="H" subId="17277790" subSource="6rag_A"/>
      <ConstraintRegion from="51" to="76" loc="O" subId="17277791" subSource="6rag_A"/>
      <ConstraintRegion from="77" to="96" loc="H" subId="17277792" subSource="6rag_A"/>
      <ConstraintRegion from="97" to="153" loc="I" subId="17277793" subSource="6rag_A"/>
      <ConstraintRegion from="154" to="175" loc="H" subId="17277794" subSource="6rag_A"/>
      <ConstraintRegion from="176" to="176" loc="O" subId="17277795" subSource="6rag_A"/>
      <ConstraintRegion from="177" to="195" loc="H" subId="17277796" subSource="6rag_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17277797" subSource="6rag_A"/>
      <ConstraintRegion from="256" to="276" loc="H" subId="17277798" subSource="6rag_A"/>
      <ConstraintRegion from="277" to="294" loc="O" subId="17277799" subSource="6rag_A"/>
      <ConstraintRegion from="295" to="312" loc="H" subId="17277800" subSource="6rag_A"/>
      <ConstraintRegion from="313" to="596" loc="I" subId="17277801" subSource="6rag_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6raf_A">
      <ConstraintRegion from="11" to="22" loc="I" subId="17277596" subSource="6raf_A"/>
      <ConstraintRegion from="23" to="46" loc="H" subId="17277599" subSource="6raf_A"/>
      <ConstraintRegion from="47" to="81" loc="O" subId="17277602" subSource="6raf_A"/>
      <ConstraintRegion from="82" to="104" loc="H" subId="17277604" subSource="6raf_A"/>
      <ConstraintRegion from="105" to="146" loc="I" subId="17277605" subSource="6raf_A"/>
      <ConstraintRegion from="147" to="169" loc="H" subId="17277606" subSource="6raf_A"/>
      <ConstraintRegion from="170" to="180" loc="O" subId="17277608" subSource="6raf_A"/>
      <ConstraintRegion from="181" to="200" loc="H" subId="17277611" subSource="6raf_A"/>
      <ConstraintRegion from="201" to="252" loc="I" subId="17277613" subSource="6raf_A"/>
      <ConstraintRegion from="253" to="273" loc="H" subId="17277616" subSource="6raf_A"/>
      <ConstraintRegion from="274" to="297" loc="O" subId="17277618" subSource="6raf_A"/>
      <ConstraintRegion from="298" to="317" loc="H" subId="17277622" subSource="6raf_A"/>
      <ConstraintRegion from="318" to="598" loc="I" subId="17277626" subSource="6raf_A"/>
      <ConstraintRegion from="11" to="11" loc="I" subId="17278284" subSource="6raj_A"/>
      <ConstraintRegion from="12" to="25" loc="F" subId="17278287" subSource="6raj_A"/>
      <ConstraintRegion from="26" to="46" loc="H" subId="17278290" subSource="6raj_A"/>
      <ConstraintRegion from="47" to="77" loc="O" subId="17278293" subSource="6raj_A"/>
      <ConstraintRegion from="78" to="99" loc="H" subId="17278297" subSource="6raj_A"/>
      <ConstraintRegion from="100" to="147" loc="I" subId="17278301" subSource="6raj_A"/>
      <ConstraintRegion from="148" to="170" loc="H" subId="17278306" subSource="6raj_A"/>
      <ConstraintRegion from="171" to="177" loc="O" subId="17278314" subSource="6raj_A"/>
      <ConstraintRegion from="178" to="196" loc="H" subId="17278317" subSource="6raj_A"/>
      <ConstraintRegion from="197" to="255" loc="I" subId="17278322" subSource="6raj_A"/>
      <ConstraintRegion from="256" to="274" loc="H" subId="17278326" subSource="6raj_A"/>
      <ConstraintRegion from="275" to="298" loc="O" subId="17278329" subSource="6raj_A"/>
      <ConstraintRegion from="299" to="317" loc="H" subId="17278333" subSource="6raj_A"/>
      <ConstraintRegion from="318" to="598" loc="I" subId="17278335" subSource="6raj_A"/>
      <ConstraintRegion from="11" to="30" loc="I" subId="17278499" subSource="6rak_A"/>
      <ConstraintRegion from="31" to="47" loc="H" subId="17278502" subSource="6rak_A"/>
      <ConstraintRegion from="48" to="78" loc="O" subId="17278504" subSource="6rak_A"/>
      <ConstraintRegion from="79" to="94" loc="H" subId="17278506" subSource="6rak_A"/>
      <ConstraintRegion from="95" to="153" loc="I" subId="17278509" subSource="6rak_A"/>
      <ConstraintRegion from="154" to="170" loc="H" subId="17278512" subSource="6rak_A"/>
      <ConstraintRegion from="171" to="180" loc="O" subId="17278515" subSource="6rak_A"/>
      <ConstraintRegion from="181" to="194" loc="H" subId="17278518" subSource="6rak_A"/>
      <ConstraintRegion from="195" to="258" loc="I" subId="17278521" subSource="6rak_A"/>
      <ConstraintRegion from="259" to="273" loc="H" subId="17278524" subSource="6rak_A"/>
      <ConstraintRegion from="274" to="296" loc="O" subId="17278527" subSource="6rak_A"/>
      <ConstraintRegion from="297" to="312" loc="H" subId="17278530" subSource="6rak_A"/>
      <ConstraintRegion from="313" to="598" loc="I" subId="17278533" subSource="6rak_A"/>
      <ConstraintRegion from="11" to="11" loc="I" subId="17278944" subSource="6ram_A"/>
      <ConstraintRegion from="12" to="19" loc="F" subId="17278946" subSource="6ram_A"/>
      <ConstraintRegion from="20" to="27" loc="I" subId="17278948" subSource="6ram_A"/>
      <ConstraintRegion from="28" to="48" loc="H" subId="17278950" subSource="6ram_A"/>
      <ConstraintRegion from="49" to="77" loc="O" subId="17278952" subSource="6ram_A"/>
      <ConstraintRegion from="78" to="98" loc="H" subId="17278954" subSource="6ram_A"/>
      <ConstraintRegion from="99" to="150" loc="I" subId="17278956" subSource="6ram_A"/>
      <ConstraintRegion from="151" to="171" loc="H" subId="17278958" subSource="6ram_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17278960" subSource="6ram_A"/>
      <ConstraintRegion from="178" to="197" loc="H" subId="17278961" subSource="6ram_A"/>
      <ConstraintRegion from="198" to="254" loc="I" subId="17278962" subSource="6ram_A"/>
      <ConstraintRegion from="255" to="274" loc="H" subId="17278964" subSource="6ram_A"/>
      <ConstraintRegion from="275" to="296" loc="O" subId="17278966" subSource="6ram_A"/>
      <ConstraintRegion from="297" to="314" loc="H" subId="17278968" subSource="6ram_A"/>
      <ConstraintRegion from="315" to="598" loc="I" subId="17278970" subSource="6ram_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rah_A">
      <ConstraintRegion from="11" to="12" loc="I" subId="17277943" subSource="6rah_A"/>
      <ConstraintRegion from="13" to="26" loc="F" subId="17277946" subSource="6rah_A"/>
      <ConstraintRegion from="27" to="47" loc="H" subId="17277948" subSource="6rah_A"/>
      <ConstraintRegion from="48" to="74" loc="O" subId="17277950" subSource="6rah_A"/>
      <ConstraintRegion from="75" to="98" loc="H" subId="17277952" subSource="6rah_A"/>
      <ConstraintRegion from="99" to="149" loc="I" subId="17277954" subSource="6rah_A"/>
      <ConstraintRegion from="150" to="168" loc="H" subId="17277955" subSource="6rah_A"/>
      <ConstraintRegion from="169" to="180" loc="O" subId="17277957" subSource="6rah_A"/>
      <ConstraintRegion from="181" to="198" loc="H" subId="17277959" subSource="6rah_A"/>
      <ConstraintRegion from="199" to="254" loc="I" subId="17277961" subSource="6rah_A"/>
      <ConstraintRegion from="255" to="272" loc="H" subId="17277963" subSource="6rah_A"/>
      <ConstraintRegion from="273" to="299" loc="O" subId="17277965" subSource="6rah_A"/>
      <ConstraintRegion from="300" to="317" loc="H" subId="17277968" subSource="6rah_A"/>
      <ConstraintRegion from="318" to="596" loc="I" subId="17277969" subSource="6rah_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ran_A">
      <ConstraintRegion from="11" to="30" loc="I" subId="17279068" subSource="6ran_A"/>
      <ConstraintRegion from="31" to="48" loc="H" subId="17279070" subSource="6ran_A"/>
      <ConstraintRegion from="49" to="78" loc="O" subId="17279072" subSource="6ran_A"/>
      <ConstraintRegion from="79" to="95" loc="H" subId="17279074" subSource="6ran_A"/>
      <ConstraintRegion from="96" to="153" loc="I" subId="17279076" subSource="6ran_A"/>
      <ConstraintRegion from="154" to="171" loc="H" subId="17279078" subSource="6ran_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17279079" subSource="6ran_A"/>
      <ConstraintRegion from="178" to="195" loc="H" subId="17279080" subSource="6ran_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17279081" subSource="6ran_A"/>
      <ConstraintRegion from="256" to="274" loc="H" subId="17279082" subSource="6ran_A"/>
      <ConstraintRegion from="275" to="296" loc="O" subId="17279083" subSource="6ran_A"/>
      <ConstraintRegion from="297" to="312" loc="H" subId="17279084" subSource="6ran_A"/>
      <ConstraintRegion from="313" to="602" loc="I" subId="17279085" subSource="6ran_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rai_A">
      <ConstraintRegion from="11" to="13" loc="I" subId="17278103" subSource="6rai_A"/>
      <ConstraintRegion from="14" to="23" loc="F" subId="17278104" subSource="6rai_A"/>
      <ConstraintRegion from="24" to="27" loc="I" subId="17278105" subSource="6rai_A"/>
      <ConstraintRegion from="28" to="47" loc="H" subId="17278107" subSource="6rai_A"/>
      <ConstraintRegion from="48" to="80" loc="O" subId="17278108" subSource="6rai_A"/>
      <ConstraintRegion from="81" to="98" loc="H" subId="17278110" subSource="6rai_A"/>
      <ConstraintRegion from="99" to="151" loc="I" subId="17278112" subSource="6rai_A"/>
      <ConstraintRegion from="152" to="170" loc="H" subId="17278113" subSource="6rai_A"/>
      <ConstraintRegion from="171" to="177" loc="O" subId="17278114" subSource="6rai_A"/>
      <ConstraintRegion from="178" to="194" loc="H" subId="17278116" subSource="6rai_A"/>
      <ConstraintRegion from="195" to="258" loc="I" subId="17278118" subSource="6rai_A"/>
      <ConstraintRegion from="259" to="275" loc="H" subId="17278120" subSource="6rai_A"/>
      <ConstraintRegion from="276" to="296" loc="O" subId="17278121" subSource="6rai_A"/>
      <ConstraintRegion from="297" to="314" loc="H" subId="17278122" subSource="6rai_A"/>
      <ConstraintRegion from="315" to="597" loc="I" subId="17278124" subSource="6rai_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
