<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="I3L391_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Calcium voltage-gated channel subunit alpha1 A </Name>
  <CrossRef>
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      <Chain id="A"/>
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      <Chain id="C"/>
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      <Chain id="A"/>
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      <Chain id="H"/>
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    <PDBTM id="7eeb">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="CAC1D_HUMAN">
      <Alignment>
        <CrossRefSeq>SNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG</CrossRefSeq>
        <OrigSeq>SVAYENALRVFNIVFTSLFSLECVLKVMAFG----ILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRAT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1C_RABIT">
      <Alignment>
        <CrossRefSeq>NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN4A_HUMAN">
      <Alignment>
        <CrossRefSeq>NQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1C_HUMAN">
      <Alignment>
        <CrossRefSeq>KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR</CrossRefSeq>
        <OrigSeq>NALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN5A_RAT">
      <Alignment>
        <CrossRefSeq>DQSPEKVNILAKINLLFVAIFTGECIVKMAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN1A_RAT">
      <Alignment>
        <CrossRefSeq>DQSDYVTSILSRINLVFIVLFTGECVLKLISLRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN9A_HUMAN">
      <Alignment>
        <CrossRefSeq>KTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRT</CrossRefSeq>
        <OrigSeq>VAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPRS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN5A_HUMAN">
      <Alignment>
        <CrossRefSeq>DQSPEKINILAKINLLFVAIFTGECIVKLAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1S_MOUSE">
      <Alignment>
        <CrossRefSeq>NQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLR</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN2A_RAT">
      <Alignment>
        <CrossRefSeq>DQSQEMTNILYWINLVFIVLFTGECVLKLISLRHY-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN2A_HUMAN">
      <Alignment>
        <CrossRefSeq>YIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRT</CrossRefSeq>
        <OrigSeq>FYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPRS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1C_RAT">
      <Alignment>
        <CrossRefSeq>NHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_HUMAN">
      <Alignment>
        <CrossRefSeq>QHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLR</CrossRefSeq>
        <OrigSeq>KFYGASVA--YENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_MOUSE">
      <Alignment>
        <CrossRefSeq>QHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLR</CrossRefSeq>
        <OrigSeq>KFYGASVA--YENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_RABIT">
      <Alignment>
        <CrossRefSeq>PMSERLDDTEPY----FIGIFCFEAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_RAT">
      <Alignment>
        <CrossRefSeq>PMSERLDDTEPY----FIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRTLRAVRVLR</CrossRefSeq>
        <OrigSeq>GASVAYENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_HUMAN">
      <Alignment>
        <CrossRefSeq>MSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLR</CrossRefSeq>
        <OrigSeq>YENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1S_HUMAN">
      <Alignment>
        <CrossRefSeq>YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAP</CrossRefSeq>
        <OrigSeq>FYGASVAYENALRVF----NIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1E_HUMAN">
      <Alignment>
        <CrossRefSeq>NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFGAWSRA----TPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNAA_RAT">
      <Alignment>
        <CrossRefSeq>TDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRA</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFGI----LNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPRS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_DROME">
      <Alignment>
        <CrossRefSeq>NKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLR</CrossRefSeq>
        <OrigSeq>ENALRVFNIVFTSLFSLECVLKVMAFG----ILNYFRDAWNIFDFVTVLGSITDILVTEFG---AWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TPC1_MOUSE">
      <Alignment>
        <CrossRefSeq>LVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFYFIVVLR</CrossRefSeq>
        <OrigSeq>IVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGAWSRATPPSPR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="79" CheckSum="6dbce329b6ec426034b7fea4f4f9ecb6">
    <Seq>
      XKFYGASVAY ENALRVFNIV FTSLFSLECV LKVMAFGILN YFRDAWNIFD
      FVTVLGSITD ILVTEFGAWS RATPPSPRS
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="78.89">
    <Region from="1" to="15" loc="O"/>
    <Region from="16" to="31" loc="M"/>
    <Region from="32" to="47" loc="I"/>
    <Region from="48" to="63" loc="M"/>
    <Region from="64" to="79" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="39" loc="M"/>
      <Region from="40" to="51" loc="O"/>
      <Region from="52" to="77" loc="M"/>
      <Region from="78" to="79" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="13" loc="O"/>
      <Region from="14" to="36" loc="M"/>
      <Region from="37" to="48" loc="I"/>
      <Region from="49" to="64" loc="M"/>
      <Region from="65" to="79" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="37" loc="M"/>
      <Region from="38" to="47" loc="I"/>
      <Region from="48" to="68" loc="M"/>
      <Region from="69" to="79" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="39" loc="M"/>
      <Region from="40" to="47" loc="O"/>
      <Region from="48" to="69" loc="M"/>
      <Region from="70" to="79" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="19" loc="O"/>
      <Region from="20" to="42" loc="M"/>
      <Region from="43" to="48" loc="I"/>
      <Region from="49" to="69" loc="M"/>
      <Region from="70" to="79" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="79" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="51" loc="O"/>
      <Region from="52" to="72" loc="M"/>
      <Region from="73" to="79" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="19" loc="O"/>
      <Region from="20" to="42" loc="M"/>
      <Region from="43" to="79" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6n4i_C">
      <ConstraintRegion from="720" to="720" loc="I" subId="17201037" subSource="6n4i_C"/>
      <ConstraintRegion from="721" to="731" loc="F" subId="17201039" subSource="6n4i_C"/>
      <ConstraintRegion from="732" to="735" loc="I" subId="17201041" subSource="6n4i_C"/>
      <ConstraintRegion from="736" to="753" loc="H" subId="17201043" subSource="6n4i_C"/>
      <ConstraintRegion from="754" to="765" loc="O" subId="17201045" subSource="6n4i_C"/>
      <ConstraintRegion from="766" to="784" loc="H" subId="17201047" subSource="6n4i_C"/>
      <ConstraintRegion from="785" to="795" loc="I" subId="17201049" subSource="6n4i_C"/>
      <ConstraintRegion from="796" to="813" loc="H" subId="17201051" subSource="6n4i_C"/>
      <ConstraintRegion from="814" to="821" loc="O" subId="17201053" subSource="6n4i_C"/>
      <ConstraintRegion from="822" to="837" loc="H" subId="17201056" subSource="6n4i_C"/>
      <ConstraintRegion from="838" to="854" loc="F" subId="17201058" subSource="6n4i_C"/>
      <ConstraintRegion from="855" to="874" loc="H" subId="17201060" subSource="6n4i_C"/>
      <ConstraintRegion from="875" to="887" loc="O" subId="17201062" subSource="6n4i_C"/>
      <ConstraintRegion from="888" to="904" loc="L" subId="17201064" subSource="6n4i_C"/>
      <ConstraintRegion from="905" to="918" loc="O" subId="17201066" subSource="6n4i_C"/>
      <ConstraintRegion from="919" to="937" loc="H" subId="17201068" subSource="6n4i_C"/>
      <ConstraintRegion from="938" to="945" loc="I" subId="17201069" subSource="6n4i_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8pd3_A">
      <ConstraintRegion from="70" to="74" loc="O" subId="19147969" subSource="8pd3_A"/>
      <ConstraintRegion from="75" to="95" loc="H" subId="19147970" subSource="8pd3_A"/>
      <ConstraintRegion from="96" to="98" loc="I" subId="19147971" subSource="8pd3_A"/>
      <ConstraintRegion from="99" to="114" loc="H" subId="19147972" subSource="8pd3_A"/>
      <ConstraintRegion from="115" to="135" loc="O" subId="19147973" subSource="8pd3_A"/>
      <ConstraintRegion from="136" to="151" loc="H" subId="19147974" subSource="8pd3_A"/>
      <ConstraintRegion from="152" to="167" loc="I" subId="19147975" subSource="8pd3_A"/>
      <ConstraintRegion from="168" to="185" loc="H" subId="19147976" subSource="8pd3_A"/>
      <ConstraintRegion from="186" to="198" loc="O" subId="19147977" subSource="8pd3_A"/>
      <ConstraintRegion from="199" to="212" loc="H" subId="19147978" subSource="8pd3_A"/>
      <ConstraintRegion from="213" to="233" loc="I" subId="19147979" subSource="8pd3_A"/>
      <ConstraintRegion from="234" to="249" loc="H" subId="19147980" subSource="8pd3_A"/>
      <ConstraintRegion from="250" to="261" loc="O" subId="19147981" subSource="8pd3_A"/>
      <ConstraintRegion from="262" to="283" loc="H" subId="19147982" subSource="8pd3_A"/>
      <ConstraintRegion from="284" to="302" loc="I" subId="19147983" subSource="8pd3_A"/>
      <ConstraintRegion from="303" to="319" loc="H" subId="19147984" subSource="8pd3_A"/>
      <ConstraintRegion from="321" to="331" loc="H" subId="19147985" subSource="8pd3_A"/>
      <ConstraintRegion from="332" to="353" loc="I" subId="19147986" subSource="8pd3_A"/>
      <ConstraintRegion from="354" to="372" loc="H" subId="19147987" subSource="8pd3_A"/>
      <ConstraintRegion from="373" to="385" loc="O" subId="19147988" subSource="8pd3_A"/>
      <ConstraintRegion from="386" to="406" loc="H" subId="19147989" subSource="8pd3_A"/>
      <ConstraintRegion from="407" to="426" loc="I" subId="19147990" subSource="8pd3_A"/>
      <ConstraintRegion from="427" to="441" loc="H" subId="19147991" subSource="8pd3_A"/>
      <ConstraintRegion from="442" to="455" loc="O" subId="19147992" subSource="8pd3_A"/>
      <ConstraintRegion from="456" to="473" loc="H" subId="19147993" subSource="8pd3_A"/>
      <ConstraintRegion from="474" to="537" loc="I" subId="19147994" subSource="8pd3_A"/>
      <ConstraintRegion from="570" to="654" loc="I" subId="19147996" subSource="8pd3_A"/>
      <ConstraintRegion from="676" to="686" loc="I" subId="19147998" subSource="8pd3_A"/>
      <ConstraintRegion from="687" to="701" loc="H" subId="19147999" subSource="8pd3_A"/>
      <ConstraintRegion from="702" to="706" loc="O" subId="19148000" subSource="8pd3_A"/>
      <ConstraintRegion from="725" to="729" loc="O" subId="19148002" subSource="8pd3_A"/>
      <ConstraintRegion from="730" to="745" loc="H" subId="19148003" subSource="8pd3_A"/>
      <ConstraintRegion from="746" to="768" loc="I" subId="19148004" subSource="8pd3_A"/>
      <ConstraintRegion from="769" to="784" loc="H" subId="19148005" subSource="8pd3_A"/>
      <ConstraintRegion from="794" to="796" loc="O" subId="19148007" subSource="8pd3_A"/>
      <ConstraintRegion from="797" to="812" loc="H" subId="19148008" subSource="8pd3_A"/>
      <ConstraintRegion from="813" to="1012" loc="I" subId="19148009" subSource="8pd3_A"/>
      <ConstraintRegion from="1030" to="1194" loc="I" subId="19148011" subSource="8pd3_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5hvd_A">
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17113487" subSource="5hvd_A"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17113488" subSource="5hvd_A"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17113490" subSource="5hvd_A"/>
      <ConstraintRegion from="13" to="34" loc="H" subId="17113492" subSource="5hvd_A"/>
      <ConstraintRegion from="35" to="40" loc="O" subId="17113494" subSource="5hvd_A"/>
      <ConstraintRegion from="41" to="65" loc="H" subId="17113496" subSource="5hvd_A"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113498" subSource="5hvd_A"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113500" subSource="5hvd_A"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113502" subSource="5hvd_A"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113504" subSource="5hvd_A"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113506" subSource="5hvd_A"/>
      <ConstraintRegion from="120" to="153" loc="H" subId="17113508" subSource="5hvd_A"/>
      <ConstraintRegion from="154" to="163" loc="O" subId="17113510" subSource="5hvd_A"/>
      <ConstraintRegion from="164" to="182" loc="L" subId="17113511" subSource="5hvd_A"/>
      <ConstraintRegion from="183" to="191" loc="F" subId="17113512" subSource="5hvd_A"/>
      <ConstraintRegion from="192" to="194" loc="O" subId="17113514" subSource="5hvd_A"/>
      <ConstraintRegion from="195" to="222" loc="H" subId="17113516" subSource="5hvd_A"/>
      <ConstraintRegion from="223" to="261" loc="I" subId="17113518" subSource="5hvd_A"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17113522" subSource="5hvd_B"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17113524" subSource="5hvd_B"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17113526" subSource="5hvd_B"/>
      <ConstraintRegion from="13" to="34" loc="H" subId="17113528" subSource="5hvd_B"/>
      <ConstraintRegion from="35" to="40" loc="O" subId="17113530" subSource="5hvd_B"/>
      <ConstraintRegion from="41" to="65" loc="H" subId="17113532" subSource="5hvd_B"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113533" subSource="5hvd_B"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113534" subSource="5hvd_B"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113536" subSource="5hvd_B"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113538" subSource="5hvd_B"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113540" subSource="5hvd_B"/>
      <ConstraintRegion from="120" to="153" loc="H" subId="17113542" subSource="5hvd_B"/>
      <ConstraintRegion from="154" to="163" loc="O" subId="17113544" subSource="5hvd_B"/>
      <ConstraintRegion from="164" to="182" loc="L" subId="17113546" subSource="5hvd_B"/>
      <ConstraintRegion from="183" to="191" loc="F" subId="17113548" subSource="5hvd_B"/>
      <ConstraintRegion from="192" to="194" loc="O" subId="17113550" subSource="5hvd_B"/>
      <ConstraintRegion from="195" to="222" loc="H" subId="17113552" subSource="5hvd_B"/>
      <ConstraintRegion from="223" to="261" loc="I" subId="17113554" subSource="5hvd_B"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17113558" subSource="5hvd_C"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17113561" subSource="5hvd_C"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17113564" subSource="5hvd_C"/>
      <ConstraintRegion from="13" to="34" loc="H" subId="17113567" subSource="5hvd_C"/>
      <ConstraintRegion from="35" to="40" loc="O" subId="17113570" subSource="5hvd_C"/>
      <ConstraintRegion from="41" to="65" loc="H" subId="17113573" subSource="5hvd_C"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113576" subSource="5hvd_C"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113579" subSource="5hvd_C"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113582" subSource="5hvd_C"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113585" subSource="5hvd_C"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113588" subSource="5hvd_C"/>
      <ConstraintRegion from="120" to="153" loc="H" subId="17113590" subSource="5hvd_C"/>
      <ConstraintRegion from="154" to="163" loc="O" subId="17113593" subSource="5hvd_C"/>
      <ConstraintRegion from="164" to="182" loc="L" subId="17113596" subSource="5hvd_C"/>
      <ConstraintRegion from="183" to="191" loc="F" subId="17113599" subSource="5hvd_C"/>
      <ConstraintRegion from="192" to="194" loc="O" subId="17113602" subSource="5hvd_C"/>
      <ConstraintRegion from="195" to="222" loc="H" subId="17113605" subSource="5hvd_C"/>
      <ConstraintRegion from="223" to="261" loc="I" subId="17113607" subSource="5hvd_C"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17113612" subSource="5hvd_D"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17113614" subSource="5hvd_D"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17113615" subSource="5hvd_D"/>
      <ConstraintRegion from="13" to="34" loc="H" subId="17113616" subSource="5hvd_D"/>
      <ConstraintRegion from="35" to="40" loc="O" subId="17113618" subSource="5hvd_D"/>
      <ConstraintRegion from="41" to="65" loc="H" subId="17113620" subSource="5hvd_D"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113622" subSource="5hvd_D"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113624" subSource="5hvd_D"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113626" subSource="5hvd_D"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113628" subSource="5hvd_D"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113630" subSource="5hvd_D"/>
      <ConstraintRegion from="120" to="153" loc="H" subId="17113632" subSource="5hvd_D"/>
      <ConstraintRegion from="154" to="163" loc="O" subId="17113634" subSource="5hvd_D"/>
      <ConstraintRegion from="164" to="182" loc="L" subId="17113636" subSource="5hvd_D"/>
      <ConstraintRegion from="183" to="191" loc="F" subId="17113638" subSource="5hvd_D"/>
      <ConstraintRegion from="192" to="194" loc="O" subId="17113639" subSource="5hvd_D"/>
      <ConstraintRegion from="195" to="222" loc="H" subId="17113640" subSource="5hvd_D"/>
      <ConstraintRegion from="223" to="261" loc="I" subId="17113642" subSource="5hvd_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yz0_A">
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448533" subSource="6yz0_A"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448535" subSource="6yz0_A"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17448537" subSource="6yz0_A"/>
      <ConstraintRegion from="13" to="30" loc="H" subId="17448538" subSource="6yz0_A"/>
      <ConstraintRegion from="31" to="47" loc="O" subId="17448540" subSource="6yz0_A"/>
      <ConstraintRegion from="48" to="65" loc="H" subId="17448542" subSource="6yz0_A"/>
      <ConstraintRegion from="66" to="75" loc="I" subId="17448544" subSource="6yz0_A"/>
      <ConstraintRegion from="76" to="91" loc="H" subId="17448545" subSource="6yz0_A"/>
      <ConstraintRegion from="92" to="92" loc="O" subId="17448547" subSource="6yz0_A"/>
      <ConstraintRegion from="100" to="102" loc="O" subId="17448549" subSource="6yz0_A"/>
      <ConstraintRegion from="103" to="118" loc="H" subId="17448551" subSource="6yz0_A"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17448553" subSource="6yz0_A"/>
      <ConstraintRegion from="120" to="147" loc="H" subId="17448555" subSource="6yz0_A"/>
      <ConstraintRegion from="148" to="163" loc="O" subId="17448557" subSource="6yz0_A"/>
      <ConstraintRegion from="164" to="175" loc="F" subId="17448559" subSource="6yz0_A"/>
      <ConstraintRegion from="176" to="197" loc="O" subId="17448561" subSource="6yz0_A"/>
      <ConstraintRegion from="198" to="222" loc="H" subId="17448564" subSource="6yz0_A"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17448567" subSource="6yz0_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yz2_A">
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448704" subSource="6yz2_A"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448706" subSource="6yz2_A"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448709" subSource="6yz2_A"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448711" subSource="6yz2_A"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448713" subSource="6yz2_A"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448716" subSource="6yz2_A"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448718" subSource="6yz2_A"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448721" subSource="6yz2_A"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448722" subSource="6yz2_A"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448723" subSource="6yz2_A"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448726" subSource="6yz2_A"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448728" subSource="6yz2_A"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448731" subSource="6yz2_A"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448734" subSource="6yz2_A"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448735" subSource="6yz2_A"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448736" subSource="6yz2_A"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448739" subSource="6yz2_A"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448741" subSource="6yz2_A"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448745" subSource="6yz2_B"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448747" subSource="6yz2_B"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448749" subSource="6yz2_B"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448751" subSource="6yz2_B"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448753" subSource="6yz2_B"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448756" subSource="6yz2_B"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448758" subSource="6yz2_B"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448760" subSource="6yz2_B"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448763" subSource="6yz2_B"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448766" subSource="6yz2_B"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448769" subSource="6yz2_B"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448772" subSource="6yz2_B"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448775" subSource="6yz2_B"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448778" subSource="6yz2_B"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448781" subSource="6yz2_B"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448784" subSource="6yz2_B"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448787" subSource="6yz2_B"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448790" subSource="6yz2_B"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448800" subSource="6yz2_C"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448803" subSource="6yz2_C"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448807" subSource="6yz2_C"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448811" subSource="6yz2_C"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448814" subSource="6yz2_C"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448817" subSource="6yz2_C"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448820" subSource="6yz2_C"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448823" subSource="6yz2_C"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448827" subSource="6yz2_C"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448830" subSource="6yz2_C"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448833" subSource="6yz2_C"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448836" subSource="6yz2_C"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448839" subSource="6yz2_C"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448843" subSource="6yz2_C"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448846" subSource="6yz2_C"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448849" subSource="6yz2_C"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448852" subSource="6yz2_C"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448855" subSource="6yz2_C"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448864" subSource="6yz2_D"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448866" subSource="6yz2_D"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448868" subSource="6yz2_D"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448871" subSource="6yz2_D"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448874" subSource="6yz2_D"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448878" subSource="6yz2_D"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448882" subSource="6yz2_D"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448885" subSource="6yz2_D"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448888" subSource="6yz2_D"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448892" subSource="6yz2_D"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448896" subSource="6yz2_D"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448900" subSource="6yz2_D"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448904" subSource="6yz2_D"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448908" subSource="6yz2_D"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448910" subSource="6yz2_D"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448914" subSource="6yz2_D"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448918" subSource="6yz2_D"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448922" subSource="6yz2_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5hvx_A">
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113713" subSource="5hvx_A"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113715" subSource="5hvx_A"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113717" subSource="5hvx_A"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113719" subSource="5hvx_A"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113721" subSource="5hvx_A"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113723" subSource="5hvx_A"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113727" subSource="5hvx_A"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113729" subSource="5hvx_A"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113730" subSource="5hvx_A"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113732" subSource="5hvx_A"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113734" subSource="5hvx_A"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113735" subSource="5hvx_A"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113737" subSource="5hvx_A"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113739" subSource="5hvx_A"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113740" subSource="5hvx_A"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113745" subSource="5hvx_B"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113746" subSource="5hvx_B"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113747" subSource="5hvx_B"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113748" subSource="5hvx_B"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113749" subSource="5hvx_B"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113750" subSource="5hvx_B"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113752" subSource="5hvx_B"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113753" subSource="5hvx_B"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113754" subSource="5hvx_B"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113755" subSource="5hvx_B"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113756" subSource="5hvx_B"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113757" subSource="5hvx_B"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113758" subSource="5hvx_B"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113759" subSource="5hvx_B"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113760" subSource="5hvx_B"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113766" subSource="5hvx_C"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113768" subSource="5hvx_C"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113770" subSource="5hvx_C"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113772" subSource="5hvx_C"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113774" subSource="5hvx_C"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113776" subSource="5hvx_C"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113780" subSource="5hvx_C"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113782" subSource="5hvx_C"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113784" subSource="5hvx_C"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113786" subSource="5hvx_C"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113788" subSource="5hvx_C"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113790" subSource="5hvx_C"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113792" subSource="5hvx_C"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113794" subSource="5hvx_C"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113796" subSource="5hvx_C"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113803" subSource="5hvx_D"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113804" subSource="5hvx_D"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113805" subSource="5hvx_D"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113806" subSource="5hvx_D"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113807" subSource="5hvx_D"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113808" subSource="5hvx_D"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113810" subSource="5hvx_D"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113811" subSource="5hvx_D"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113812" subSource="5hvx_D"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113813" subSource="5hvx_D"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113814" subSource="5hvx_D"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113815" subSource="5hvx_D"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113816" subSource="5hvx_D"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113817" subSource="5hvx_D"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113818" subSource="5hvx_D"/>
    </Constraint>
  </Constraints>
</HtpItem>
