<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="M0R2V0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>hyaluronan synthase </Name>
  <CrossRef>
    <PDBTM id="8smp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8smn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8smm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8snc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sne">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7sp7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7sp9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7spa">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7sp8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8snd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7sp6">
      <Chain id="A"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="585" CheckSum="94ea9cf6e0b728a45d77fa05a19601df">
    <Seq>
      MPLPFPSRSQ QDAPKPTPAA CRCSGLARRV LTIAFALLIL GLMTWAYAAG
      VPLASDRYGL LAFGLYGAFL SAHLVAQSLF AYLEHRRVAA AARGPLDAAT
      ARSVALTISA YQEDPAYLRQ CLASARALLY PRARLRVLMV VDGNRAEDLY
      MVDMFREVFA DEDPATYVWD GNYHQPWEPA AAGAVGAGAY REVEAEDPGR
      LAVEALVRTR RCVCVAQRWG GKREVMYTAF KALGDSVDYV QVCDSDTRLD
      PMALLELVRV LDEDPRVGAV GGDVRILNPL DSWVSFLSSL RYWVAFNVER
      ACQSYFHCVS CISGPLGLYR NNLLQQFLEA WYNQKFLGTH CTFGDDRHLT
      NRMLSMGYAT KYTSRSRCYS ETPSSFLRWL SQQTRWSKSY FREWLYNALW
      WHRHHAWMTY EAVVSGLFPF FVAATVLRLF YAGRPWALLW VLLCVQGVAL
      AKAAFAAWLR GCLRMVLLSL YAPLYMCGLL PAKFLALVTM NQSGWGTSGR
      RKLAANYVPL LPLALWALLL LGGLVRSVAH EARADWSGPS RAAEAYHLAA
      GAGAYVGYWV AMLTLYWVGV RRLCRRRTGG YRVQV
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="73.73">
    <Region from="1" to="29" loc="I"/>
    <Region from="30" to="49" loc="M"/>
    <Region from="50" to="59" loc="O"/>
    <Region from="60" to="81" loc="M"/>
    <Region from="82" to="305" loc="I"/>
    <Region from="306" to="318" loc="M"/>
    <Region from="319" to="408" loc="O"/>
    <Region from="409" to="430" loc="M"/>
    <Region from="431" to="435" loc="I"/>
    <Region from="436" to="457" loc="M"/>
    <Region from="458" to="462" loc="O"/>
    <Region from="463" to="487" loc="M"/>
    <Region from="488" to="506" loc="I"/>
    <Region from="507" to="528" loc="M"/>
    <Region from="529" to="547" loc="O"/>
    <Region from="548" to="569" loc="M"/>
    <Region from="570" to="585" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="54" loc="M"/>
      <Region from="55" to="411" loc="O"/>
      <Region from="412" to="427" loc="M"/>
      <Region from="428" to="434" loc="I"/>
      <Region from="435" to="459" loc="M"/>
      <Region from="460" to="462" loc="O"/>
      <Region from="463" to="490" loc="M"/>
      <Region from="491" to="502" loc="I"/>
      <Region from="503" to="528" loc="M"/>
      <Region from="529" to="544" loc="O"/>
      <Region from="545" to="570" loc="M"/>
      <Region from="571" to="585" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="38" loc="O"/>
      <Region from="39" to="54" loc="M"/>
      <Region from="55" to="58" loc="I"/>
      <Region from="59" to="82" loc="M"/>
      <Region from="83" to="302" loc="O"/>
      <Region from="303" to="318" loc="M"/>
      <Region from="319" to="406" loc="I"/>
      <Region from="407" to="431" loc="M"/>
      <Region from="432" to="435" loc="O"/>
      <Region from="436" to="459" loc="M"/>
      <Region from="460" to="463" loc="I"/>
      <Region from="464" to="489" loc="M"/>
      <Region from="490" to="510" loc="O"/>
      <Region from="511" to="528" loc="M"/>
      <Region from="529" to="545" loc="I"/>
      <Region from="546" to="571" loc="M"/>
      <Region from="572" to="585" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="24" loc="I"/>
      <Region from="25" to="55" loc="M"/>
      <Region from="56" to="60" loc="O"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="301" loc="I"/>
      <Region from="302" to="315" loc="L"/>
      <Region from="316" to="406" loc="I"/>
      <Region from="407" to="427" loc="M"/>
      <Region from="428" to="433" loc="O"/>
      <Region from="434" to="454" loc="M"/>
      <Region from="455" to="459" loc="I"/>
      <Region from="460" to="480" loc="M"/>
      <Region from="481" to="506" loc="O"/>
      <Region from="507" to="527" loc="M"/>
      <Region from="528" to="539" loc="I"/>
      <Region from="540" to="554" loc="M"/>
      <Region from="555" to="555" loc="O"/>
      <Region from="556" to="570" loc="M"/>
      <Region from="571" to="585" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="49" loc="M"/>
      <Region from="50" to="59" loc="O"/>
      <Region from="60" to="83" loc="M"/>
      <Region from="84" to="406" loc="I"/>
      <Region from="407" to="430" loc="M"/>
      <Region from="431" to="435" loc="O"/>
      <Region from="436" to="459" loc="M"/>
      <Region from="460" to="460" loc="I"/>
      <Region from="461" to="475" loc="M"/>
      <Region from="476" to="476" loc="O"/>
      <Region from="477" to="491" loc="M"/>
      <Region from="492" to="504" loc="I"/>
      <Region from="505" to="529" loc="M"/>
      <Region from="530" to="545" loc="O"/>
      <Region from="546" to="569" loc="M"/>
      <Region from="570" to="585" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="48" loc="M"/>
      <Region from="49" to="59" loc="O"/>
      <Region from="60" to="83" loc="M"/>
      <Region from="84" to="411" loc="I"/>
      <Region from="412" to="431" loc="M"/>
      <Region from="432" to="436" loc="O"/>
      <Region from="437" to="459" loc="M"/>
      <Region from="460" to="465" loc="I"/>
      <Region from="466" to="487" loc="M"/>
      <Region from="488" to="506" loc="O"/>
      <Region from="507" to="525" loc="M"/>
      <Region from="526" to="545" loc="I"/>
      <Region from="546" to="568" loc="M"/>
      <Region from="569" to="585" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="28" loc="I"/>
      <Region from="29" to="49" loc="M"/>
      <Region from="50" to="59" loc="O"/>
      <Region from="60" to="80" loc="M"/>
      <Region from="81" to="300" loc="I"/>
      <Region from="301" to="321" loc="M"/>
      <Region from="322" to="405" loc="O"/>
      <Region from="406" to="426" loc="M"/>
      <Region from="427" to="435" loc="I"/>
      <Region from="436" to="456" loc="M"/>
      <Region from="457" to="466" loc="O"/>
      <Region from="467" to="487" loc="M"/>
      <Region from="488" to="507" loc="I"/>
      <Region from="508" to="528" loc="M"/>
      <Region from="529" to="548" loc="O"/>
      <Region from="549" to="569" loc="M"/>
      <Region from="570" to="585" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="30" loc="I"/>
      <Region from="31" to="51" loc="M"/>
      <Region from="52" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="300" loc="I"/>
      <Region from="301" to="321" loc="M"/>
      <Region from="322" to="409" loc="O"/>
      <Region from="410" to="430" loc="M"/>
      <Region from="431" to="436" loc="I"/>
      <Region from="437" to="457" loc="M"/>
      <Region from="458" to="467" loc="O"/>
      <Region from="468" to="488" loc="M"/>
      <Region from="489" to="508" loc="I"/>
      <Region from="509" to="529" loc="M"/>
      <Region from="530" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="585" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="62" loc="O"/>
      <Region from="63" to="82" loc="M"/>
      <Region from="83" to="275" loc="I"/>
      <Region from="276" to="295" loc="M"/>
      <Region from="296" to="411" loc="O"/>
      <Region from="412" to="431" loc="M"/>
      <Region from="432" to="434" loc="I"/>
      <Region from="435" to="454" loc="M"/>
      <Region from="455" to="456" loc="O"/>
      <Region from="457" to="476" loc="M"/>
      <Region from="477" to="508" loc="I"/>
      <Region from="509" to="528" loc="M"/>
      <Region from="529" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="585" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="28" loc="I"/>
      <Region from="29" to="49" loc="M"/>
      <Region from="50" to="62" loc="O"/>
      <Region from="63" to="83" loc="M"/>
      <Region from="84" to="300" loc="I"/>
      <Region from="301" to="321" loc="M"/>
      <Region from="322" to="410" loc="O"/>
      <Region from="411" to="431" loc="M"/>
      <Region from="432" to="437" loc="I"/>
      <Region from="438" to="458" loc="M"/>
      <Region from="459" to="461" loc="O"/>
      <Region from="462" to="482" loc="M"/>
      <Region from="483" to="509" loc="I"/>
      <Region from="510" to="530" loc="M"/>
      <Region from="531" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="585" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="28" loc="I"/>
      <Region from="29" to="51" loc="M"/>
      <Region from="52" to="60" loc="O"/>
      <Region from="61" to="83" loc="M"/>
      <Region from="84" to="409" loc="I"/>
      <Region from="410" to="432" loc="M"/>
      <Region from="433" to="436" loc="O"/>
      <Region from="437" to="459" loc="M"/>
      <Region from="460" to="465" loc="I"/>
      <Region from="466" to="488" loc="M"/>
      <Region from="489" to="502" loc="O"/>
      <Region from="503" to="525" loc="M"/>
      <Region from="526" to="545" loc="I"/>
      <Region from="546" to="568" loc="M"/>
      <Region from="569" to="585" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="7sp7_A">
      <ConstraintRegion from="38" to="41" loc="O" subId="17307809" subSource="7sp7_A"/>
      <ConstraintRegion from="42" to="62" loc="H" subId="17307812" subSource="7sp7_A"/>
      <ConstraintRegion from="63" to="365" loc="I" subId="17307814" subSource="7sp7_A"/>
      <ConstraintRegion from="366" to="390" loc="H" subId="17307818" subSource="7sp7_A"/>
      <ConstraintRegion from="391" to="397" loc="O" subId="17307820" subSource="7sp7_A"/>
      <ConstraintRegion from="398" to="420" loc="H" subId="17307822" subSource="7sp7_A"/>
      <ConstraintRegion from="421" to="421" loc="I" subId="17307825" subSource="7sp7_A"/>
      <ConstraintRegion from="469" to="473" loc="I" subId="17307836" subSource="7sp7_A"/>
      <ConstraintRegion from="474" to="492" loc="H" subId="17307839" subSource="7sp7_A"/>
      <ConstraintRegion from="493" to="513" loc="O" subId="17307842" subSource="7sp7_A"/>
      <ConstraintRegion from="514" to="534" loc="H" subId="17307845" subSource="7sp7_A"/>
      <ConstraintRegion from="535" to="552" loc="I" subId="17307848" subSource="7sp7_A"/>
      <ConstraintRegion from="422" to="450" loc="F" subId="22873347" subSource="7sp7_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7sp9_A">
      <ConstraintRegion from="38" to="38" loc="O" subId="17308031" subSource="7sp9_A"/>
      <ConstraintRegion from="39" to="59" loc="H" subId="17308035" subSource="7sp9_A"/>
      <ConstraintRegion from="60" to="368" loc="I" subId="17308037" subSource="7sp9_A"/>
      <ConstraintRegion from="369" to="394" loc="H" subId="17308040" subSource="7sp9_A"/>
      <ConstraintRegion from="395" to="395" loc="O" subId="17308045" subSource="7sp9_A"/>
      <ConstraintRegion from="396" to="418" loc="H" subId="17308046" subSource="7sp9_A"/>
      <ConstraintRegion from="419" to="420" loc="I" subId="17308047" subSource="7sp9_A"/>
      <ConstraintRegion from="470" to="470" loc="I" subId="17308055" subSource="7sp9_A"/>
      <ConstraintRegion from="471" to="496" loc="H" subId="17308057" subSource="7sp9_A"/>
      <ConstraintRegion from="497" to="509" loc="O" subId="17308060" subSource="7sp9_A"/>
      <ConstraintRegion from="510" to="537" loc="H" subId="17308062" subSource="7sp9_A"/>
      <ConstraintRegion from="538" to="552" loc="I" subId="17308064" subSource="7sp9_A"/>
      <ConstraintRegion from="421" to="451" loc="F" subId="22873348" subSource="7sp9_A"/>
      <ConstraintRegion from="38" to="38" loc="O" subId="17308121" subSource="7spa_A"/>
      <ConstraintRegion from="39" to="55" loc="H" subId="17308122" subSource="7spa_A"/>
      <ConstraintRegion from="56" to="372" loc="I" subId="17308124" subSource="7spa_A"/>
      <ConstraintRegion from="373" to="394" loc="H" subId="17308126" subSource="7spa_A"/>
      <ConstraintRegion from="395" to="395" loc="O" subId="17308128" subSource="7spa_A"/>
      <ConstraintRegion from="396" to="414" loc="H" subId="17308129" subSource="7spa_A"/>
      <ConstraintRegion from="415" to="424" loc="I" subId="17308130" subSource="7spa_A"/>
      <ConstraintRegion from="445" to="451" loc="I" subId="17308134" subSource="7spa_A"/>
      <ConstraintRegion from="470" to="476" loc="I" subId="17308140" subSource="7spa_A"/>
      <ConstraintRegion from="477" to="500" loc="H" subId="17308143" subSource="7spa_A"/>
      <ConstraintRegion from="501" to="505" loc="O" subId="17308147" subSource="7spa_A"/>
      <ConstraintRegion from="506" to="533" loc="H" subId="17308150" subSource="7spa_A"/>
      <ConstraintRegion from="534" to="552" loc="I" subId="17308153" subSource="7spa_A"/>
      <ConstraintRegion from="425" to="444" loc="F" subId="22873349" subSource="7spa_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7sp6_A">
      <ConstraintRegion from="38" to="39" loc="O" subId="17307684" subSource="7sp6_A"/>
      <ConstraintRegion from="40" to="60" loc="H" subId="17307688" subSource="7sp6_A"/>
      <ConstraintRegion from="61" to="368" loc="I" subId="17307690" subSource="7sp6_A"/>
      <ConstraintRegion from="369" to="390" loc="H" subId="17307694" subSource="7sp6_A"/>
      <ConstraintRegion from="391" to="397" loc="O" subId="17307698" subSource="7sp6_A"/>
      <ConstraintRegion from="398" to="418" loc="H" subId="17307702" subSource="7sp6_A"/>
      <ConstraintRegion from="419" to="420" loc="I" subId="17307704" subSource="7sp6_A"/>
      <ConstraintRegion from="449" to="449" loc="I" subId="17307710" subSource="7sp6_A"/>
      <ConstraintRegion from="472" to="474" loc="I" subId="17307715" subSource="7sp6_A"/>
      <ConstraintRegion from="475" to="493" loc="H" subId="17307719" subSource="7sp6_A"/>
      <ConstraintRegion from="494" to="513" loc="O" subId="17307723" subSource="7sp6_A"/>
      <ConstraintRegion from="514" to="534" loc="H" subId="17307726" subSource="7sp6_A"/>
      <ConstraintRegion from="535" to="552" loc="I" subId="17307730" subSource="7sp6_A"/>
      <ConstraintRegion from="421" to="448" loc="F" subId="22873346" subSource="7sp6_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
