<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="NCLX_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Mitochondrial sodium/calcium exchanger protein </Name>
  <CrossRef>
    <PDBTM id="8jp0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hxc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hxs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hxh">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hwy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3v5s">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3v5u">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hxe">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hya">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hxr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5hwx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5jdq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sgt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sgj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sgi">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="NCKX2_HUMAN">
      <Alignment>
        <CrossRefSeq>AISTVSFSISAFSETDTQSTGEASVVSGPRVAQGYHQRTLLDL--------NDKILDYTPQPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHS-NVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFF-PITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIV--LLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRIL</CrossRefSeq>
        <OrigSeq>ALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSL------LPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILH--PFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTV----ILCTWIYQRQRRGSLFCPMP----VTPEILSDSEEDRVSSNTNSYDYGDE-YRPLFFYQETTAQILVRALNPL-DYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLV------VVLTLQSGTYGVYEIGGLVPVWVVVVIAGTA--------------------------LASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQ-ISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NAC1_CANLF">
      <Alignment>
        <CrossRefSeq>GSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM-SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISP-----GVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDE</CrossRefSeq>
        <OrigSeq>GYLDYLEGIFCHFPPSLLPL------AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKL------------------SHNVAGVTFLAFGNGAPDIFSALVAFSDP--HTAGLALGALFGAGVLVTTVVAGGITILHP-------------FMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVIL-------CTWIYQRQRRGSLFCPMPVT----PEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YRBG_ECOLI">
      <Alignment>
        <CrossRefSeq>LGIALIIMPVATRMVVDNATVLANYFAISELTMGLTAIAIGTSLPELATA-IAGVRKGENDIAVGNIIGANIFNIVIVLGLPALITPGEIDPLAYSRDYSVMLLVSIIFALLCWRRSPQPGRGVG-VLLTGGFIVWLAMLYWL</CrossRefSeq>
        <OrigSeq>LYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWI</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="584" CheckSum="89470badfe9aac3ce1523dcaa5ebd6bd">
    <Seq>
      MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV
      VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV
      TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG
      APDIFSALVA FSDPHTAGLA LGALFGAGVL VTTVVAGGIT ILHPFMAASR
      PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY VVTVILCTWI
      YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET
      TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD
      DQNWKRPLNC LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA
      LASVTFFATS DSQPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVV
      FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL
      VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF SLVSVPLQCF
      QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="77.78">
    <Region from="1" to="26" loc="T"/>
    <Region from="27" to="97" loc="O"/>
    <Region from="98" to="119" loc="M"/>
    <Region from="120" to="137" loc="I"/>
    <Region from="138" to="159" loc="M"/>
    <Region from="160" to="168" loc="O"/>
    <Region from="169" to="191" loc="M"/>
    <Region from="192" to="201" loc="I"/>
    <Region from="202" to="222" loc="M"/>
    <Region from="223" to="224" loc="O"/>
    <Region from="225" to="248" loc="M"/>
    <Region from="249" to="357" loc="I"/>
    <Region from="358" to="378" loc="M"/>
    <Region from="379" to="385" loc="O"/>
    <Region from="386" to="407" loc="M"/>
    <Region from="408" to="416" loc="I"/>
    <Region from="417" to="437" loc="M"/>
    <Region from="438" to="446" loc="O"/>
    <Region from="447" to="470" loc="M"/>
    <Region from="471" to="486" loc="I"/>
    <Region from="487" to="509" loc="M"/>
    <Region from="510" to="523" loc="O"/>
    <Region from="524" to="545" loc="M"/>
    <Region from="546" to="554" loc="I"/>
    <Region from="555" to="578" loc="M"/>
    <Region from="579" to="584" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="97" loc="O"/>
      <Region from="98" to="119" loc="M"/>
      <Region from="120" to="138" loc="I"/>
      <Region from="139" to="160" loc="M"/>
      <Region from="161" to="167" loc="O"/>
      <Region from="168" to="192" loc="M"/>
      <Region from="193" to="205" loc="I"/>
      <Region from="206" to="227" loc="M"/>
      <Region from="228" to="229" loc="O"/>
      <Region from="230" to="251" loc="M"/>
      <Region from="252" to="328" loc="I"/>
      <Region from="329" to="345" loc="M"/>
      <Region from="346" to="359" loc="O"/>
      <Region from="360" to="381" loc="M"/>
      <Region from="382" to="383" loc="I"/>
      <Region from="384" to="405" loc="M"/>
      <Region from="406" to="419" loc="O"/>
      <Region from="420" to="441" loc="M"/>
      <Region from="442" to="446" loc="I"/>
      <Region from="447" to="470" loc="M"/>
      <Region from="471" to="486" loc="O"/>
      <Region from="487" to="509" loc="M"/>
      <Region from="510" to="523" loc="I"/>
      <Region from="524" to="545" loc="M"/>
      <Region from="546" to="557" loc="O"/>
      <Region from="558" to="579" loc="M"/>
      <Region from="580" to="584" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="95" loc="I"/>
      <Region from="96" to="126" loc="M"/>
      <Region from="127" to="168" loc="O"/>
      <Region from="169" to="192" loc="M"/>
      <Region from="193" to="202" loc="I"/>
      <Region from="203" to="222" loc="M"/>
      <Region from="223" to="225" loc="O"/>
      <Region from="226" to="249" loc="M"/>
      <Region from="250" to="358" loc="I"/>
      <Region from="359" to="375" loc="M"/>
      <Region from="376" to="386" loc="O"/>
      <Region from="387" to="407" loc="M"/>
      <Region from="408" to="420" loc="I"/>
      <Region from="421" to="450" loc="M"/>
      <Region from="451" to="458" loc="O"/>
      <Region from="459" to="474" loc="M"/>
      <Region from="475" to="486" loc="I"/>
      <Region from="487" to="508" loc="M"/>
      <Region from="509" to="526" loc="O"/>
      <Region from="527" to="547" loc="M"/>
      <Region from="548" to="555" loc="I"/>
      <Region from="556" to="578" loc="M"/>
      <Region from="579" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="92" loc="I"/>
      <Region from="93" to="107" loc="M"/>
      <Region from="108" to="108" loc="O"/>
      <Region from="109" to="123" loc="M"/>
      <Region from="124" to="137" loc="I"/>
      <Region from="138" to="158" loc="M"/>
      <Region from="159" to="170" loc="O"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="203" loc="I"/>
      <Region from="204" to="224" loc="M"/>
      <Region from="225" to="225" loc="O"/>
      <Region from="226" to="246" loc="M"/>
      <Region from="247" to="322" loc="I"/>
      <Region from="323" to="345" loc="L"/>
      <Region from="346" to="357" loc="I"/>
      <Region from="358" to="378" loc="M"/>
      <Region from="379" to="384" loc="O"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="418" loc="I"/>
      <Region from="419" to="449" loc="M"/>
      <Region from="450" to="450" loc="O"/>
      <Region from="451" to="471" loc="M"/>
      <Region from="472" to="489" loc="I"/>
      <Region from="490" to="510" loc="M"/>
      <Region from="511" to="524" loc="O"/>
      <Region from="525" to="545" loc="M"/>
      <Region from="546" to="556" loc="I"/>
      <Region from="557" to="577" loc="M"/>
      <Region from="578" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="99" loc="O"/>
      <Region from="100" to="123" loc="M"/>
      <Region from="124" to="138" loc="I"/>
      <Region from="139" to="160" loc="M"/>
      <Region from="161" to="168" loc="O"/>
      <Region from="169" to="192" loc="M"/>
      <Region from="193" to="201" loc="I"/>
      <Region from="202" to="221" loc="M"/>
      <Region from="222" to="228" loc="O"/>
      <Region from="229" to="251" loc="M"/>
      <Region from="252" to="358" loc="I"/>
      <Region from="359" to="379" loc="M"/>
      <Region from="380" to="386" loc="O"/>
      <Region from="387" to="409" loc="M"/>
      <Region from="410" to="416" loc="I"/>
      <Region from="417" to="438" loc="M"/>
      <Region from="439" to="447" loc="O"/>
      <Region from="448" to="469" loc="M"/>
      <Region from="470" to="485" loc="I"/>
      <Region from="486" to="511" loc="M"/>
      <Region from="512" to="523" loc="O"/>
      <Region from="524" to="547" loc="M"/>
      <Region from="548" to="554" loc="I"/>
      <Region from="555" to="579" loc="M"/>
      <Region from="580" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="102" loc="O"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="134" loc="I"/>
      <Region from="135" to="161" loc="M"/>
      <Region from="162" to="166" loc="O"/>
      <Region from="167" to="190" loc="M"/>
      <Region from="191" to="201" loc="I"/>
      <Region from="202" to="221" loc="M"/>
      <Region from="222" to="226" loc="O"/>
      <Region from="227" to="251" loc="M"/>
      <Region from="252" to="325" loc="I"/>
      <Region from="326" to="344" loc="M"/>
      <Region from="345" to="355" loc="O"/>
      <Region from="356" to="374" loc="M"/>
      <Region from="375" to="385" loc="I"/>
      <Region from="386" to="407" loc="M"/>
      <Region from="408" to="418" loc="O"/>
      <Region from="419" to="437" loc="M"/>
      <Region from="438" to="448" loc="I"/>
      <Region from="449" to="466" loc="M"/>
      <Region from="467" to="485" loc="O"/>
      <Region from="486" to="512" loc="M"/>
      <Region from="513" to="523" loc="I"/>
      <Region from="524" to="543" loc="M"/>
      <Region from="544" to="554" loc="O"/>
      <Region from="555" to="579" loc="M"/>
      <Region from="580" to="584" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="93" loc="O"/>
      <Region from="94" to="114" loc="M"/>
      <Region from="115" to="134" loc="I"/>
      <Region from="135" to="155" loc="M"/>
      <Region from="156" to="171" loc="O"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="201" loc="I"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="226" loc="O"/>
      <Region from="227" to="247" loc="M"/>
      <Region from="248" to="361" loc="I"/>
      <Region from="362" to="382" loc="M"/>
      <Region from="383" to="386" loc="O"/>
      <Region from="387" to="407" loc="M"/>
      <Region from="408" to="416" loc="I"/>
      <Region from="417" to="437" loc="M"/>
      <Region from="438" to="449" loc="O"/>
      <Region from="450" to="470" loc="M"/>
      <Region from="471" to="490" loc="I"/>
      <Region from="491" to="511" loc="M"/>
      <Region from="512" to="526" loc="O"/>
      <Region from="527" to="547" loc="M"/>
      <Region from="548" to="558" loc="I"/>
      <Region from="559" to="579" loc="M"/>
      <Region from="580" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="100" loc="O"/>
      <Region from="101" to="121" loc="M"/>
      <Region from="122" to="130" loc="I"/>
      <Region from="131" to="151" loc="M"/>
      <Region from="152" to="171" loc="O"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="201" loc="I"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="226" loc="O"/>
      <Region from="227" to="247" loc="M"/>
      <Region from="248" to="357" loc="I"/>
      <Region from="358" to="378" loc="M"/>
      <Region from="379" to="387" loc="O"/>
      <Region from="388" to="408" loc="M"/>
      <Region from="409" to="417" loc="I"/>
      <Region from="418" to="438" loc="M"/>
      <Region from="439" to="458" loc="O"/>
      <Region from="459" to="479" loc="M"/>
      <Region from="480" to="488" loc="I"/>
      <Region from="489" to="509" loc="M"/>
      <Region from="510" to="524" loc="O"/>
      <Region from="525" to="545" loc="M"/>
      <Region from="546" to="554" loc="I"/>
      <Region from="555" to="575" loc="M"/>
      <Region from="576" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="101" loc="I"/>
      <Region from="102" to="122" loc="M"/>
      <Region from="123" to="165" loc="O"/>
      <Region from="166" to="185" loc="M"/>
      <Region from="186" to="206" loc="I"/>
      <Region from="207" to="226" loc="M"/>
      <Region from="227" to="230" loc="O"/>
      <Region from="231" to="250" loc="M"/>
      <Region from="251" to="325" loc="I"/>
      <Region from="326" to="345" loc="M"/>
      <Region from="346" to="359" loc="O"/>
      <Region from="360" to="379" loc="M"/>
      <Region from="380" to="386" loc="I"/>
      <Region from="387" to="406" loc="M"/>
      <Region from="407" to="415" loc="O"/>
      <Region from="416" to="435" loc="M"/>
      <Region from="436" to="448" loc="I"/>
      <Region from="449" to="468" loc="M"/>
      <Region from="469" to="488" loc="O"/>
      <Region from="489" to="508" loc="M"/>
      <Region from="509" to="524" loc="I"/>
      <Region from="525" to="544" loc="M"/>
      <Region from="545" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="584" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="94" loc="I"/>
      <Region from="95" to="115" loc="M"/>
      <Region from="116" to="171" loc="O"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="204" loc="I"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="226" loc="O"/>
      <Region from="227" to="247" loc="M"/>
      <Region from="248" to="357" loc="I"/>
      <Region from="358" to="378" loc="M"/>
      <Region from="379" to="385" loc="O"/>
      <Region from="386" to="406" loc="M"/>
      <Region from="407" to="420" loc="I"/>
      <Region from="421" to="441" loc="M"/>
      <Region from="442" to="448" loc="O"/>
      <Region from="449" to="469" loc="M"/>
      <Region from="470" to="491" loc="I"/>
      <Region from="492" to="512" loc="M"/>
      <Region from="513" to="524" loc="O"/>
      <Region from="525" to="545" loc="M"/>
      <Region from="546" to="555" loc="I"/>
      <Region from="556" to="576" loc="M"/>
      <Region from="577" to="584" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region from="1" to="26" loc="T"/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="26" loc="T"/>
      <Region from="27" to="95" loc="O"/>
      <Region from="96" to="118" loc="M"/>
      <Region from="119" to="138" loc="I"/>
      <Region from="139" to="161" loc="M"/>
      <Region from="162" to="170" loc="O"/>
      <Region from="171" to="193" loc="M"/>
      <Region from="194" to="205" loc="I"/>
      <Region from="206" to="225" loc="M"/>
      <Region from="226" to="228" loc="O"/>
      <Region from="229" to="251" loc="M"/>
      <Region from="252" to="322" loc="I"/>
      <Region from="323" to="345" loc="M"/>
      <Region from="346" to="359" loc="O"/>
      <Region from="360" to="382" loc="M"/>
      <Region from="383" to="386" loc="I"/>
      <Region from="387" to="409" loc="M"/>
      <Region from="410" to="418" loc="O"/>
      <Region from="419" to="441" loc="M"/>
      <Region from="442" to="447" loc="I"/>
      <Region from="448" to="470" loc="M"/>
      <Region from="471" to="489" loc="O"/>
      <Region from="490" to="512" loc="M"/>
      <Region from="513" to="524" loc="I"/>
      <Region from="525" to="547" loc="M"/>
      <Region from="548" to="556" loc="O"/>
      <Region from="557" to="579" loc="M"/>
      <Region from="580" to="584" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
