<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="Q496J0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>SLC26A5 protein </Name>
  <CrossRef>
    <PDBTM id="7lgu">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lgw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lh2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lh3">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s9a">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s9d">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s9e">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s9b">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7v75">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s9c">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7s8x">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8uc1">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7v73">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7v74">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7sun">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wk1">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wl2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wl7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wl9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wla">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wk7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hzn">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wle">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7xuh">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7xuj">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7xul">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8iet">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8opq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6rtc">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6rtf">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8sgw">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8sh3">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8shc">
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8sie">
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8uuk">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7xlm">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ch1">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tnw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tnx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lhv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tny">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ki1">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5da0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5iof">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <TOPDB id="S26A5_MERUN">
      <Alignment>
        <CrossRefSeq>MDHAEENEIPVATQKYHVERPIFSHPVLQERLHVKDKVSESIGDKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQF</CrossRefSeq>
        <OrigSeq>MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVSS---------LFLGLDYGLITAVIIALLTVIYRTQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S26A5_RAT">
      <Alignment>
        <CrossRefSeq>MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGDKLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQF</CrossRefSeq>
        <OrigSeq>MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVSS---------LFLGLDYGLITAVIIALLTVIYRTQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S26A3_HUMAN">
      <Alignment>
        <CrossRefSeq>IEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQF</CrossRefSeq>
        <OrigSeq>ILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTE-------ARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVSSLFLG---------LDYGLITAVIIALLTVIYRTQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S26A6_HUMAN">
      <Alignment>
        <CrossRefSeq>TQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-----NDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQ</CrossRefSeq>
        <OrigSeq>ENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVSS---------LFLGLDYGLITAVIIALLTVIYRT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S26A7_HUMAN">
      <Alignment>
        <CrossRefSeq>KRKKKSMLWSKMHTPQC--EDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFR</CrossRefSeq>
        <OrigSeq>DKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGG--VNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVS---------SLFLGLDYGLITAVIIALLTVIYRTQR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SUL2_YEAST">
      <Alignment>
        <CrossRefSeq>QFEETTVSLKEYYDHSIRS--HLTVKGACSYLKSVFPIINWLPHYNFS-WFTADLIAGITIGCVLVPQSMSYAQVATLPAQYGLYSSFIGAYSYSFFATSKDVCIGPVAVMSLQTAKVIADVTAK-----------YPDGDSAITGPVIATTLALLCGIISAAVGFLRLGFLVELISLNAVAGFMTGSAFNILWGQVPALMGYNSLVNTRA-ATYKVVIETLKHLPDTKL-DAVFGLIPLFLLYVWKWWCGTYGPRLNDRYNSKNPRLHKIIKWTYFYAQASRNGIIIIVFTCIGWAITRGKSKSERPISILGSVPSGLKEVGVFHVPPGLMSKLGPNLPASIIVLLLEHIAISKSFGRINDYKVVPDQELIAIGVSNLLGTFFNAYPATGSFSRSALKAKCNVRTPLSGLFSGSCVLLALYCLTGAFFYIPKATLSAVIIHAVSDLLASYQ</CrossRefSeq>
        <OrigSeq>ERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERF-----------KEKLPAPIPLEF---------FAVVMGTGISAGFNL---KESYNVDVVGTLPLGLLPPANP--DTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTT---------FVSSLFLGLDYGLITAVIIALLTVIYRTQR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SULX_YEAST">
      <Alignment>
        <CrossRefSeq>VFETLPYYLPCFSWLPEYTFNK-LWGDVIAGISVASFQIPLALSYTTSIAHVPPLCGLYSLAISPFVYGILGSVPQMIVGPESAISLVVGQAVESITLHKENVSL---------------IDISTVITFVSGTILLFSGISRFGFLGNVLSKALLRGFISSVGLVMIINSLISELKLDKFLVSLPQHYHT-PFEKILFLIDYAPA--QYHIPTAIFSGCCLIVLFLTRLLKRKLMKYHKSAIFFPDILLVVIVTILISMKFNLKHRYGISIIGDFSMDNFDELKNPLTRPRRKLIPDLFSASLIVAMLGFFESTTASKSLGTTYNLTVSSNRELVALGFMNIVISLFGALPAFGGYGRSKINALSGAQSVMSGVFMGVITLITMNLLLQFVHYIPNCVLSVITTIIGISLLE</CrossRefSeq>
        <OrigSeq>IRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAM-LAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSML-------KYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKE--KLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGL-----LPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLTTFVSSLF---------LGLDYGLITAVIIALLTVIYR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DAUA_ECO57">
      <Alignment>
        <CrossRefSeq>WKEKYTAARFTR-DLIAGITVGIIAIPLAMALAIGSGVAPQYGLYTAAVAGIVIALTGGSRFSVSGPTAAFVVILYPVSQQFGLAGLLV-----------------------ATLLSGIFLILMGLARFGRLIEYIPVSVTLGFTSGIGITIGTMQIKDFLGLQMAHVPEHY--LQKVGALFMALPTINVGDAAIGIVTLGILVFW--------PRLGIRLPGHLPALLAGCAVMGIVNLLGGH-VATIGSQFHYVLADGSQGNGIPQLLPQLVLPWDLPNSEFTLTWDSIRTLLPAAFSMAMLGAIESLLCAVVLDGMTGTKHKANSELVGQGLGNIIAPFFGGITATAAIARSAANVRAGATSPISAVIHSILVILALLVLAPLLSWLPLSAMAALLLMVAWNMSEAHK</CrossRefSeq>
        <OrigSeq>WLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGT--------------LPLGLLPPANP----------DTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQTIWLT---------TFVSSLFLGLDYGLITAVIIALLTVIYRTQR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="447" CheckSum="bb5b26dfa248e70caf68774665b9f4ed">
    <Seq>
      MDHAEENEIL AATQRYYVER PIFSHPVLQE RLHTKDKVPD SIADKLKQAF
      TCTPKKIRNI IYMFLPITKW LPAYKFKEYV LGDLVSGIST GVLQLPQGLA
      FAMLAAVPPI FGLYSSFYPV IMYCFLGTSR HISIGPFAVI SLMIGGVAVR
      LVPDDIVIPG GVNATNGTEA RDALRVKVAM SVTLLSGIIQ FCLGVCRFGF
      VAIYLTEPLV RGFTTAAAVH VFTSMLKYLF GVKTKRYSGI FSVVYSTVAV
      LQNVKNLNVC SLGVGLMVFG LLLGGKEFNE RFKEKLPAPI PLEFFAVVMG
      TGISAGFNLK ESYNVDVVGT LPLGLLPPAN PDTSLFHLVY VDAIAIAIVG
      FSVTISMAKT LANKHGYQVD GNQELIALGL CNSIGSLFQT FSISCSLSRS
      LVQEGTGGKT QTIWLTTFVS SLFLGLDYGL ITAVIIALLT VIYRTQR
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="94.36">
    <Region from="1" to="83" loc="I"/>
    <Region from="84" to="104" loc="M"/>
    <Region from="105" to="109" loc="O"/>
    <Region from="110" to="126" loc="M"/>
    <Region from="127" to="131" loc="I"/>
    <Region from="132" to="144" loc="M"/>
    <Region from="145" to="178" loc="O"/>
    <Region from="179" to="195" loc="M"/>
    <Region from="196" to="211" loc="I"/>
    <Region from="212" to="226" loc="M"/>
    <Region from="227" to="236" loc="O"/>
    <Region from="237" to="247" loc="L"/>
    <Region from="248" to="263" loc="O"/>
    <Region from="264" to="278" loc="M"/>
    <Region from="279" to="288" loc="I"/>
    <Region from="289" to="301" loc="M"/>
    <Region from="302" to="338" loc="O"/>
    <Region from="339" to="356" loc="M"/>
    <Region from="357" to="372" loc="I"/>
    <Region from="373" to="387" loc="M"/>
    <Region from="388" to="389" loc="O"/>
    <Region from="390" to="402" loc="M"/>
    <Region from="403" to="410" loc="I"/>
    <Region from="411" to="422" loc="M"/>
    <Region from="423" to="428" loc="O"/>
    <Region from="429" to="443" loc="M"/>
    <Region from="444" to="447" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="83" loc="I"/>
      <Region from="84" to="107" loc="M"/>
      <Region from="108" to="137" loc="O"/>
      <Region from="138" to="149" loc="M"/>
      <Region from="150" to="177" loc="I"/>
      <Region from="178" to="203" loc="M"/>
      <Region from="204" to="208" loc="O"/>
      <Region from="209" to="232" loc="M"/>
      <Region from="233" to="237" loc="I"/>
      <Region from="238" to="251" loc="M"/>
      <Region from="252" to="258" loc="O"/>
      <Region from="259" to="275" loc="M"/>
      <Region from="276" to="285" loc="I"/>
      <Region from="286" to="309" loc="M"/>
      <Region from="310" to="337" loc="O"/>
      <Region from="338" to="358" loc="M"/>
      <Region from="359" to="374" loc="I"/>
      <Region from="375" to="395" loc="M"/>
      <Region from="396" to="411" loc="O"/>
      <Region from="412" to="437" loc="M"/>
      <Region from="438" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="82" loc="I"/>
      <Region from="83" to="101" loc="M"/>
      <Region from="102" to="104" loc="O"/>
      <Region from="105" to="126" loc="M"/>
      <Region from="127" to="132" loc="I"/>
      <Region from="133" to="148" loc="M"/>
      <Region from="149" to="174" loc="O"/>
      <Region from="175" to="205" loc="M"/>
      <Region from="206" to="208" loc="I"/>
      <Region from="209" to="227" loc="M"/>
      <Region from="228" to="256" loc="O"/>
      <Region from="257" to="276" loc="M"/>
      <Region from="277" to="289" loc="I"/>
      <Region from="290" to="308" loc="M"/>
      <Region from="309" to="336" loc="O"/>
      <Region from="337" to="358" loc="M"/>
      <Region from="359" to="377" loc="I"/>
      <Region from="378" to="396" loc="M"/>
      <Region from="397" to="412" loc="O"/>
      <Region from="413" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="51" loc="O"/>
      <Region from="52" to="72" loc="M"/>
      <Region from="73" to="81" loc="I"/>
      <Region from="82" to="102" loc="M"/>
      <Region from="103" to="103" loc="O"/>
      <Region from="104" to="124" loc="M"/>
      <Region from="125" to="130" loc="I"/>
      <Region from="131" to="151" loc="M"/>
      <Region from="152" to="175" loc="O"/>
      <Region from="176" to="206" loc="M"/>
      <Region from="207" to="208" loc="I"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="240" loc="O"/>
      <Region from="241" to="249" loc="L"/>
      <Region from="250" to="255" loc="O"/>
      <Region from="256" to="276" loc="M"/>
      <Region from="277" to="285" loc="I"/>
      <Region from="286" to="306" loc="M"/>
      <Region from="307" to="319" loc="O"/>
      <Region from="320" to="324" loc="L"/>
      <Region from="325" to="336" loc="O"/>
      <Region from="337" to="357" loc="M"/>
      <Region from="358" to="375" loc="I"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="412" loc="O"/>
      <Region from="413" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="78" loc="I"/>
      <Region from="79" to="96" loc="M"/>
      <Region from="97" to="97" loc="O"/>
      <Region from="98" to="126" loc="M"/>
      <Region from="127" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="177" loc="O"/>
      <Region from="178" to="201" loc="M"/>
      <Region from="202" to="208" loc="I"/>
      <Region from="209" to="231" loc="M"/>
      <Region from="232" to="253" loc="O"/>
      <Region from="254" to="275" loc="M"/>
      <Region from="276" to="287" loc="I"/>
      <Region from="288" to="309" loc="M"/>
      <Region from="310" to="335" loc="O"/>
      <Region from="336" to="358" loc="M"/>
      <Region from="359" to="374" loc="I"/>
      <Region from="375" to="397" loc="M"/>
      <Region from="398" to="421" loc="O"/>
      <Region from="422" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="98" loc="O"/>
      <Region from="99" to="125" loc="M"/>
      <Region from="126" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="183" loc="O"/>
      <Region from="184" to="205" loc="M"/>
      <Region from="206" to="211" loc="I"/>
      <Region from="212" to="230" loc="M"/>
      <Region from="231" to="255" loc="O"/>
      <Region from="256" to="274" loc="M"/>
      <Region from="275" to="285" loc="I"/>
      <Region from="286" to="307" loc="M"/>
      <Region from="308" to="334" loc="O"/>
      <Region from="335" to="355" loc="M"/>
      <Region from="356" to="374" loc="I"/>
      <Region from="375" to="393" loc="M"/>
      <Region from="394" to="412" loc="O"/>
      <Region from="413" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="83" loc="I"/>
      <Region from="84" to="104" loc="M"/>
      <Region from="105" to="108" loc="O"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="181" loc="O"/>
      <Region from="182" to="202" loc="M"/>
      <Region from="203" to="211" loc="I"/>
      <Region from="212" to="232" loc="M"/>
      <Region from="233" to="252" loc="O"/>
      <Region from="253" to="273" loc="M"/>
      <Region from="274" to="293" loc="I"/>
      <Region from="294" to="314" loc="M"/>
      <Region from="315" to="334" loc="O"/>
      <Region from="335" to="355" loc="M"/>
      <Region from="356" to="375" loc="I"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="416" loc="O"/>
      <Region from="417" to="437" loc="M"/>
      <Region from="438" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="83" loc="I"/>
      <Region from="84" to="104" loc="M"/>
      <Region from="105" to="108" loc="O"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="131" loc="I"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="175" loc="O"/>
      <Region from="176" to="196" loc="M"/>
      <Region from="197" to="211" loc="I"/>
      <Region from="212" to="232" loc="M"/>
      <Region from="233" to="253" loc="O"/>
      <Region from="254" to="274" loc="M"/>
      <Region from="275" to="294" loc="I"/>
      <Region from="295" to="315" loc="M"/>
      <Region from="316" to="335" loc="O"/>
      <Region from="336" to="356" loc="M"/>
      <Region from="357" to="376" loc="I"/>
      <Region from="377" to="397" loc="M"/>
      <Region from="398" to="417" loc="O"/>
      <Region from="418" to="438" loc="M"/>
      <Region from="439" to="447" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="97" loc="I"/>
      <Region from="98" to="118" loc="M"/>
      <Region from="119" to="131" loc="O"/>
      <Region from="132" to="151" loc="M"/>
      <Region from="152" to="181" loc="I"/>
      <Region from="182" to="201" loc="M"/>
      <Region from="202" to="208" loc="O"/>
      <Region from="209" to="228" loc="M"/>
      <Region from="229" to="255" loc="I"/>
      <Region from="256" to="275" loc="M"/>
      <Region from="276" to="337" loc="O"/>
      <Region from="338" to="357" loc="M"/>
      <Region from="358" to="423" loc="I"/>
      <Region from="424" to="443" loc="M"/>
      <Region from="444" to="447" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="55" loc="I"/>
      <Region from="56" to="76" loc="M"/>
      <Region from="77" to="83" loc="O"/>
      <Region from="84" to="104" loc="M"/>
      <Region from="105" to="109" loc="I"/>
      <Region from="110" to="130" loc="M"/>
      <Region from="131" to="131" loc="O"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="177" loc="I"/>
      <Region from="178" to="198" loc="M"/>
      <Region from="199" to="208" loc="O"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="256" loc="I"/>
      <Region from="257" to="277" loc="M"/>
      <Region from="278" to="286" loc="O"/>
      <Region from="287" to="307" loc="M"/>
      <Region from="308" to="338" loc="I"/>
      <Region from="339" to="359" loc="M"/>
      <Region from="360" to="422" loc="O"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="98" loc="I"/>
      <Region from="99" to="121" loc="M"/>
      <Region from="122" to="130" loc="O"/>
      <Region from="131" to="153" loc="M"/>
      <Region from="154" to="183" loc="I"/>
      <Region from="184" to="206" loc="M"/>
      <Region from="207" to="209" loc="O"/>
      <Region from="210" to="232" loc="M"/>
      <Region from="233" to="252" loc="I"/>
      <Region from="253" to="275" loc="M"/>
      <Region from="276" to="332" loc="O"/>
      <Region from="333" to="355" loc="M"/>
      <Region from="356" to="374" loc="I"/>
      <Region from="375" to="397" loc="M"/>
      <Region from="398" to="411" loc="O"/>
      <Region from="412" to="443" loc="M"/>
      <Region from="444" to="447" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="7v75_A">
      <ConstraintRegion from="58" to="84" loc="I" subId="17357641" subSource="7v75_A"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357643" subSource="7v75_A"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357645" subSource="7v75_A"/>
      <ConstraintRegion from="112" to="127" loc="H" subId="17357646" subSource="7v75_A"/>
      <ConstraintRegion from="128" to="132" loc="I" subId="17357648" subSource="7v75_A"/>
      <ConstraintRegion from="133" to="147" loc="H" subId="17357650" subSource="7v75_A"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357652" subSource="7v75_A"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357656" subSource="7v75_A"/>
      <ConstraintRegion from="180" to="196" loc="H" subId="17357658" subSource="7v75_A"/>
      <ConstraintRegion from="197" to="210" loc="I" subId="17357660" subSource="7v75_A"/>
      <ConstraintRegion from="211" to="226" loc="H" subId="17357662" subSource="7v75_A"/>
      <ConstraintRegion from="227" to="264" loc="O" subId="17357663" subSource="7v75_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17357665" subSource="7v75_A"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357667" subSource="7v75_A"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357668" subSource="7v75_A"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357670" subSource="7v75_A"/>
      <ConstraintRegion from="340" to="355" loc="H" subId="17357672" subSource="7v75_A"/>
      <ConstraintRegion from="356" to="374" loc="I" subId="17357674" subSource="7v75_A"/>
      <ConstraintRegion from="375" to="389" loc="H" subId="17357676" subSource="7v75_A"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357677" subSource="7v75_A"/>
      <ConstraintRegion from="391" to="403" loc="H" subId="17357678" subSource="7v75_A"/>
      <ConstraintRegion from="404" to="411" loc="I" subId="17357680" subSource="7v75_A"/>
      <ConstraintRegion from="412" to="428" loc="H" subId="17357681" subSource="7v75_A"/>
      <ConstraintRegion from="429" to="438" loc="O" subId="17357683" subSource="7v75_A"/>
      <ConstraintRegion from="439" to="455" loc="H" subId="17357685" subSource="7v75_A"/>
      <ConstraintRegion from="456" to="473" loc="I" subId="17357686" subSource="7v75_A"/>
      <ConstraintRegion from="474" to="494" loc="L" subId="17357687" subSource="7v75_A"/>
      <ConstraintRegion from="495" to="583" loc="I" subId="17357689" subSource="7v75_A"/>
      <ConstraintRegion from="634" to="722" loc="I" subId="17357691" subSource="7v75_A"/>
      <ConstraintRegion from="58" to="84" loc="I" subId="17357694" subSource="7v75_B"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357695" subSource="7v75_B"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357696" subSource="7v75_B"/>
      <ConstraintRegion from="112" to="127" loc="H" subId="17357697" subSource="7v75_B"/>
      <ConstraintRegion from="128" to="132" loc="I" subId="17357698" subSource="7v75_B"/>
      <ConstraintRegion from="133" to="147" loc="H" subId="17357699" subSource="7v75_B"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357700" subSource="7v75_B"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357702" subSource="7v75_B"/>
      <ConstraintRegion from="180" to="196" loc="H" subId="17357704" subSource="7v75_B"/>
      <ConstraintRegion from="197" to="210" loc="I" subId="17357706" subSource="7v75_B"/>
      <ConstraintRegion from="211" to="226" loc="H" subId="17357708" subSource="7v75_B"/>
      <ConstraintRegion from="227" to="264" loc="O" subId="17357710" subSource="7v75_B"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17357712" subSource="7v75_B"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357714" subSource="7v75_B"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357716" subSource="7v75_B"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357718" subSource="7v75_B"/>
      <ConstraintRegion from="340" to="355" loc="H" subId="17357721" subSource="7v75_B"/>
      <ConstraintRegion from="356" to="374" loc="I" subId="17357723" subSource="7v75_B"/>
      <ConstraintRegion from="375" to="389" loc="H" subId="17357725" subSource="7v75_B"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357727" subSource="7v75_B"/>
      <ConstraintRegion from="391" to="403" loc="H" subId="17357729" subSource="7v75_B"/>
      <ConstraintRegion from="404" to="411" loc="I" subId="17357731" subSource="7v75_B"/>
      <ConstraintRegion from="412" to="428" loc="H" subId="17357733" subSource="7v75_B"/>
      <ConstraintRegion from="429" to="438" loc="O" subId="17357735" subSource="7v75_B"/>
      <ConstraintRegion from="439" to="455" loc="H" subId="17357737" subSource="7v75_B"/>
      <ConstraintRegion from="456" to="473" loc="I" subId="17357739" subSource="7v75_B"/>
      <ConstraintRegion from="474" to="494" loc="L" subId="17357741" subSource="7v75_B"/>
      <ConstraintRegion from="495" to="583" loc="I" subId="17357743" subSource="7v75_B"/>
      <ConstraintRegion from="634" to="722" loc="I" subId="17357747" subSource="7v75_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7v73_A">
      <ConstraintRegion from="58" to="84" loc="I" subId="17357119" subSource="7v73_A"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357123" subSource="7v73_A"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357127" subSource="7v73_A"/>
      <ConstraintRegion from="112" to="127" loc="H" subId="17357130" subSource="7v73_A"/>
      <ConstraintRegion from="128" to="133" loc="I" subId="17357133" subSource="7v73_A"/>
      <ConstraintRegion from="134" to="147" loc="H" subId="17357137" subSource="7v73_A"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357140" subSource="7v73_A"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357145" subSource="7v73_A"/>
      <ConstraintRegion from="180" to="195" loc="H" subId="17357146" subSource="7v73_A"/>
      <ConstraintRegion from="196" to="210" loc="I" subId="17357148" subSource="7v73_A"/>
      <ConstraintRegion from="211" to="226" loc="H" subId="17357149" subSource="7v73_A"/>
      <ConstraintRegion from="227" to="265" loc="O" subId="17357151" subSource="7v73_A"/>
      <ConstraintRegion from="266" to="279" loc="H" subId="17357154" subSource="7v73_A"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357155" subSource="7v73_A"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357158" subSource="7v73_A"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357162" subSource="7v73_A"/>
      <ConstraintRegion from="340" to="354" loc="H" subId="17357164" subSource="7v73_A"/>
      <ConstraintRegion from="355" to="375" loc="I" subId="17357167" subSource="7v73_A"/>
      <ConstraintRegion from="376" to="389" loc="H" subId="17357170" subSource="7v73_A"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357173" subSource="7v73_A"/>
      <ConstraintRegion from="391" to="400" loc="H" subId="17357174" subSource="7v73_A"/>
      <ConstraintRegion from="401" to="411" loc="I" subId="17357177" subSource="7v73_A"/>
      <ConstraintRegion from="412" to="428" loc="H" subId="17357181" subSource="7v73_A"/>
      <ConstraintRegion from="429" to="438" loc="O" subId="17357185" subSource="7v73_A"/>
      <ConstraintRegion from="439" to="453" loc="H" subId="17357189" subSource="7v73_A"/>
      <ConstraintRegion from="454" to="473" loc="I" subId="17357193" subSource="7v73_A"/>
      <ConstraintRegion from="474" to="493" loc="L" subId="17357197" subSource="7v73_A"/>
      <ConstraintRegion from="494" to="578" loc="I" subId="17357199" subSource="7v73_A"/>
      <ConstraintRegion from="637" to="722" loc="I" subId="17357209" subSource="7v73_A"/>
      <ConstraintRegion from="58" to="84" loc="I" subId="17357420" subSource="7v74_A"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357422" subSource="7v74_A"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357425" subSource="7v74_A"/>
      <ConstraintRegion from="112" to="126" loc="H" subId="17357428" subSource="7v74_A"/>
      <ConstraintRegion from="127" to="133" loc="I" subId="17357430" subSource="7v74_A"/>
      <ConstraintRegion from="134" to="147" loc="H" subId="17357432" subSource="7v74_A"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357434" subSource="7v74_A"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357440" subSource="7v74_A"/>
      <ConstraintRegion from="180" to="195" loc="H" subId="17357443" subSource="7v74_A"/>
      <ConstraintRegion from="196" to="212" loc="I" subId="17357446" subSource="7v74_A"/>
      <ConstraintRegion from="213" to="226" loc="H" subId="17357449" subSource="7v74_A"/>
      <ConstraintRegion from="227" to="265" loc="O" subId="17357452" subSource="7v74_A"/>
      <ConstraintRegion from="266" to="279" loc="H" subId="17357455" subSource="7v74_A"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357457" subSource="7v74_A"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357459" subSource="7v74_A"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357463" subSource="7v74_A"/>
      <ConstraintRegion from="340" to="354" loc="H" subId="17357467" subSource="7v74_A"/>
      <ConstraintRegion from="355" to="375" loc="I" subId="17357470" subSource="7v74_A"/>
      <ConstraintRegion from="376" to="389" loc="H" subId="17357473" subSource="7v74_A"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357476" subSource="7v74_A"/>
      <ConstraintRegion from="391" to="400" loc="H" subId="17357479" subSource="7v74_A"/>
      <ConstraintRegion from="401" to="412" loc="I" subId="17357482" subSource="7v74_A"/>
      <ConstraintRegion from="413" to="426" loc="H" subId="17357485" subSource="7v74_A"/>
      <ConstraintRegion from="427" to="439" loc="O" subId="17357488" subSource="7v74_A"/>
      <ConstraintRegion from="440" to="453" loc="H" subId="17357491" subSource="7v74_A"/>
      <ConstraintRegion from="454" to="473" loc="I" subId="17357494" subSource="7v74_A"/>
      <ConstraintRegion from="474" to="493" loc="L" subId="17357497" subSource="7v74_A"/>
      <ConstraintRegion from="494" to="578" loc="I" subId="17357500" subSource="7v74_A"/>
      <ConstraintRegion from="637" to="722" loc="I" subId="17357506" subSource="7v74_A"/>
      <ConstraintRegion from="58" to="84" loc="I" subId="17357231" subSource="7v73_B"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357234" subSource="7v73_B"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357237" subSource="7v73_B"/>
      <ConstraintRegion from="112" to="127" loc="H" subId="17357239" subSource="7v73_B"/>
      <ConstraintRegion from="128" to="133" loc="I" subId="17357243" subSource="7v73_B"/>
      <ConstraintRegion from="134" to="147" loc="H" subId="17357246" subSource="7v73_B"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357250" subSource="7v73_B"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357258" subSource="7v73_B"/>
      <ConstraintRegion from="180" to="195" loc="H" subId="17357263" subSource="7v73_B"/>
      <ConstraintRegion from="196" to="210" loc="I" subId="17357264" subSource="7v73_B"/>
      <ConstraintRegion from="211" to="226" loc="H" subId="17357267" subSource="7v73_B"/>
      <ConstraintRegion from="227" to="265" loc="O" subId="17357270" subSource="7v73_B"/>
      <ConstraintRegion from="266" to="279" loc="H" subId="17357274" subSource="7v73_B"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357279" subSource="7v73_B"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357283" subSource="7v73_B"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357287" subSource="7v73_B"/>
      <ConstraintRegion from="340" to="354" loc="H" subId="17357291" subSource="7v73_B"/>
      <ConstraintRegion from="355" to="375" loc="I" subId="17357296" subSource="7v73_B"/>
      <ConstraintRegion from="376" to="389" loc="H" subId="17357301" subSource="7v73_B"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357308" subSource="7v73_B"/>
      <ConstraintRegion from="391" to="400" loc="H" subId="17357314" subSource="7v73_B"/>
      <ConstraintRegion from="401" to="411" loc="I" subId="17357320" subSource="7v73_B"/>
      <ConstraintRegion from="412" to="428" loc="H" subId="17357325" subSource="7v73_B"/>
      <ConstraintRegion from="429" to="438" loc="O" subId="17357330" subSource="7v73_B"/>
      <ConstraintRegion from="439" to="453" loc="H" subId="17357335" subSource="7v73_B"/>
      <ConstraintRegion from="454" to="473" loc="I" subId="17357340" subSource="7v73_B"/>
      <ConstraintRegion from="474" to="493" loc="L" subId="17357345" subSource="7v73_B"/>
      <ConstraintRegion from="494" to="578" loc="I" subId="17357350" subSource="7v73_B"/>
      <ConstraintRegion from="637" to="722" loc="I" subId="17357359" subSource="7v73_B"/>
      <ConstraintRegion from="58" to="84" loc="I" subId="17357519" subSource="7v74_B"/>
      <ConstraintRegion from="85" to="105" loc="H" subId="17357522" subSource="7v74_B"/>
      <ConstraintRegion from="106" to="111" loc="O" subId="17357525" subSource="7v74_B"/>
      <ConstraintRegion from="112" to="126" loc="H" subId="17357526" subSource="7v74_B"/>
      <ConstraintRegion from="127" to="133" loc="I" subId="17357528" subSource="7v74_B"/>
      <ConstraintRegion from="134" to="147" loc="H" subId="17357531" subSource="7v74_B"/>
      <ConstraintRegion from="148" to="155" loc="O" subId="17357532" subSource="7v74_B"/>
      <ConstraintRegion from="166" to="179" loc="O" subId="17357537" subSource="7v74_B"/>
      <ConstraintRegion from="180" to="195" loc="H" subId="17357540" subSource="7v74_B"/>
      <ConstraintRegion from="196" to="212" loc="I" subId="17357543" subSource="7v74_B"/>
      <ConstraintRegion from="213" to="226" loc="H" subId="17357546" subSource="7v74_B"/>
      <ConstraintRegion from="227" to="265" loc="O" subId="17357549" subSource="7v74_B"/>
      <ConstraintRegion from="266" to="279" loc="H" subId="17357551" subSource="7v74_B"/>
      <ConstraintRegion from="280" to="288" loc="I" subId="17357555" subSource="7v74_B"/>
      <ConstraintRegion from="289" to="300" loc="H" subId="17357558" subSource="7v74_B"/>
      <ConstraintRegion from="301" to="339" loc="O" subId="17357561" subSource="7v74_B"/>
      <ConstraintRegion from="340" to="354" loc="H" subId="17357564" subSource="7v74_B"/>
      <ConstraintRegion from="355" to="375" loc="I" subId="17357566" subSource="7v74_B"/>
      <ConstraintRegion from="376" to="389" loc="H" subId="17357567" subSource="7v74_B"/>
      <ConstraintRegion from="390" to="390" loc="O" subId="17357570" subSource="7v74_B"/>
      <ConstraintRegion from="391" to="400" loc="H" subId="17357573" subSource="7v74_B"/>
      <ConstraintRegion from="401" to="412" loc="I" subId="17357576" subSource="7v74_B"/>
      <ConstraintRegion from="413" to="426" loc="H" subId="17357578" subSource="7v74_B"/>
      <ConstraintRegion from="427" to="439" loc="O" subId="17357580" subSource="7v74_B"/>
      <ConstraintRegion from="440" to="453" loc="H" subId="17357583" subSource="7v74_B"/>
      <ConstraintRegion from="454" to="473" loc="I" subId="17357586" subSource="7v74_B"/>
      <ConstraintRegion from="474" to="493" loc="L" subId="17357588" subSource="7v74_B"/>
      <ConstraintRegion from="494" to="578" loc="I" subId="17357590" subSource="7v74_B"/>
      <ConstraintRegion from="637" to="722" loc="I" subId="17357595" subSource="7v74_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5da0_A">
      <ConstraintRegion from="14" to="21" loc="I" subId="17027764" subSource="5da0_A"/>
      <ConstraintRegion from="22" to="47" loc="H" subId="17027765" subSource="5da0_A"/>
      <ConstraintRegion from="48" to="52" loc="O" subId="17027766" subSource="5da0_A"/>
      <ConstraintRegion from="53" to="68" loc="H" subId="17027767" subSource="5da0_A"/>
      <ConstraintRegion from="69" to="73" loc="I" subId="17027768" subSource="5da0_A"/>
      <ConstraintRegion from="74" to="90" loc="H" subId="17027769" subSource="5da0_A"/>
      <ConstraintRegion from="91" to="96" loc="O" subId="17027770" subSource="5da0_A"/>
      <ConstraintRegion from="97" to="113" loc="H" subId="17027771" subSource="5da0_A"/>
      <ConstraintRegion from="114" to="116" loc="I" subId="17027772" subSource="5da0_A"/>
      <ConstraintRegion from="117" to="122" loc="F" subId="17027773" subSource="5da0_A"/>
      <ConstraintRegion from="123" to="130" loc="I" subId="17027774" subSource="5da0_A"/>
      <ConstraintRegion from="131" to="147" loc="H" subId="17027775" subSource="5da0_A"/>
      <ConstraintRegion from="148" to="154" loc="O" subId="17027776" subSource="5da0_A"/>
      <ConstraintRegion from="155" to="172" loc="H" subId="17027777" subSource="5da0_A"/>
      <ConstraintRegion from="173" to="173" loc="I" subId="17027778" subSource="5da0_A"/>
      <ConstraintRegion from="174" to="187" loc="H" subId="17027779" subSource="5da0_A"/>
      <ConstraintRegion from="188" to="220" loc="O" subId="17027780" subSource="5da0_A"/>
      <ConstraintRegion from="221" to="239" loc="H" subId="17027781" subSource="5da0_A"/>
      <ConstraintRegion from="240" to="262" loc="I" subId="17027782" subSource="5da0_A"/>
      <ConstraintRegion from="263" to="277" loc="H" subId="17027783" subSource="5da0_A"/>
      <ConstraintRegion from="278" to="278" loc="O" subId="17027784" subSource="5da0_A"/>
      <ConstraintRegion from="279" to="288" loc="H" subId="17027785" subSource="5da0_A"/>
      <ConstraintRegion from="289" to="299" loc="I" subId="17027786" subSource="5da0_A"/>
      <ConstraintRegion from="300" to="313" loc="H" subId="17027787" subSource="5da0_A"/>
      <ConstraintRegion from="314" to="325" loc="O" subId="17027788" subSource="5da0_A"/>
      <ConstraintRegion from="326" to="340" loc="H" subId="17027789" subSource="5da0_A"/>
      <ConstraintRegion from="341" to="346" loc="I" subId="17027790" subSource="5da0_A"/>
      <ConstraintRegion from="351" to="484" loc="I" subId="17027791" subSource="5da0_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5iof_A">
      <ConstraintRegion from="14" to="28" loc="I" subId="17122339" subSource="5iof_A"/>
      <ConstraintRegion from="29" to="49" loc="H" subId="17122340" subSource="5iof_A"/>
      <ConstraintRegion from="50" to="50" loc="O" subId="17122341" subSource="5iof_A"/>
      <ConstraintRegion from="51" to="68" loc="H" subId="17122342" subSource="5iof_A"/>
      <ConstraintRegion from="69" to="74" loc="I" subId="17122344" subSource="5iof_A"/>
      <ConstraintRegion from="75" to="89" loc="H" subId="17122346" subSource="5iof_A"/>
      <ConstraintRegion from="90" to="94" loc="O" subId="17122348" subSource="5iof_A"/>
      <ConstraintRegion from="95" to="114" loc="H" subId="17122349" subSource="5iof_A"/>
      <ConstraintRegion from="115" to="116" loc="I" subId="17122350" subSource="5iof_A"/>
      <ConstraintRegion from="117" to="122" loc="F" subId="17122352" subSource="5iof_A"/>
      <ConstraintRegion from="123" to="127" loc="I" subId="17122354" subSource="5iof_A"/>
      <ConstraintRegion from="128" to="147" loc="H" subId="17122356" subSource="5iof_A"/>
      <ConstraintRegion from="148" to="152" loc="O" subId="17122357" subSource="5iof_A"/>
      <ConstraintRegion from="153" to="169" loc="H" subId="17122359" subSource="5iof_A"/>
      <ConstraintRegion from="170" to="175" loc="I" subId="17122361" subSource="5iof_A"/>
      <ConstraintRegion from="176" to="192" loc="H" subId="17122363" subSource="5iof_A"/>
      <ConstraintRegion from="193" to="223" loc="O" subId="17122364" subSource="5iof_A"/>
      <ConstraintRegion from="224" to="242" loc="H" subId="17122365" subSource="5iof_A"/>
      <ConstraintRegion from="243" to="263" loc="I" subId="17122367" subSource="5iof_A"/>
      <ConstraintRegion from="264" to="276" loc="H" subId="17122369" subSource="5iof_A"/>
      <ConstraintRegion from="277" to="277" loc="O" subId="17122371" subSource="5iof_A"/>
      <ConstraintRegion from="278" to="287" loc="I" subId="17122372" subSource="5iof_A"/>
      <ConstraintRegion from="288" to="300" loc="I" subId="17122373" subSource="5iof_A"/>
      <ConstraintRegion from="301" to="320" loc="H" subId="17122375" subSource="5iof_A"/>
      <ConstraintRegion from="321" to="321" loc="O" subId="17122377" subSource="5iof_A"/>
      <ConstraintRegion from="322" to="341" loc="H" subId="17122379" subSource="5iof_A"/>
      <ConstraintRegion from="342" to="346" loc="I" subId="17122380" subSource="5iof_A"/>
      <ConstraintRegion from="351" to="357" loc="I" subId="17122381" subSource="5iof_A"/>
      <ConstraintRegion from="358" to="370" loc="H" subId="17122383" subSource="5iof_A"/>
      <ConstraintRegion from="371" to="371" loc="O" subId="17122385" subSource="5iof_A"/>
      <ConstraintRegion from="372" to="385" loc="H" subId="17122387" subSource="5iof_A"/>
      <ConstraintRegion from="386" to="391" loc="I" subId="17122388" subSource="5iof_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
