<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="Q4R1J8_HUMAN" transmembrane="yes" evidence="Prediction">
  <Name>Gamma-secretase subunit APH-1 </Name>
  <CrossRef>
    <PDBTM id="5a63">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn2">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn3">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn4">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5fn5">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6idf">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6iyc">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6lqg">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6lr4">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7c9i">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7d8x">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5t">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5x">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y5z">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8im7">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8k8e">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x52">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x53">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8x54">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8oqz">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8oqy">
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="APH1A_HUMAN">
      <Alignment>
        <CrossRefSeq>MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG</CrossRefSeq>
        <OrigSeq>MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="81" CheckSum="03454545358597a8a47453340b0fbd4e">
    <Seq>
      MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGRR VETCKNTEAP
      DCASPSGSLS FLLVGVSTDF VPCLVHGKSH Y
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="78.11">
    <Region from="1" to="1" loc="O"/>
    <Region from="2" to="26" loc="M"/>
    <Region from="27" to="81" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="1" loc="I"/>
      <Region from="2" to="27" loc="M"/>
      <Region from="28" to="81" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="8" loc="O"/>
      <Region from="9" to="34" loc="M"/>
      <Region from="35" to="81" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="32" loc="M"/>
      <Region from="33" to="58" loc="I"/>
      <Region from="59" to="79" loc="M"/>
      <Region from="80" to="81" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="81" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="26" loc="M"/>
      <Region from="27" to="81" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="2" loc="O"/>
      <Region from="3" to="22" loc="M"/>
      <Region from="23" to="81" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="2" loc="O"/>
      <Region from="3" to="23" loc="M"/>
      <Region from="24" to="81" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="4" loc="I"/>
      <Region from="5" to="27" loc="M"/>
      <Region from="28" to="81" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
