<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="Q5T209_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Nicastrin </Name>
  <CrossRef>
    <PDBTM id="6idf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6iyc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6lqg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6lr4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7c9i">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7d8x">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7y5t">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7y5x">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7y5z">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8im7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8k8e">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8x53">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5a63">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5fn2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5fn3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5fn4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5fn5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8oqz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8x52">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8x54">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8oqy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4uis">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2n7q">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2n7r">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="NICA_HUMAN">
      <Alignment>
        <CrossRefSeq>IASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY</CrossRefSeq>
        <OrigSeq>VPSENKDLITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NICA_CAEEL">
      <Alignment>
        <CrossRefSeq>KWLVIVLIIAGIRCDGFSDQVFRTLFIGEGNACYRTFNKTHEFGCQANRENENGLIVRIDKQEDFKNLDSCWNSFYPKYSGKYWALLPVNLIRRDTISQLKS-SKCLSGIVLYNSGESIHPGDESTAASHDAECPNAASDYYLQDKNEEYC---ERKINSRGAITRDGLMKIDWRIQMVFIDNSTDLEIIEKCYSMFNKPKEDGSSGYPYCGMSFRLANMAAGNSEICYRRGKNDAKLFQMNIDSGDAPQLCGAMHSDNIFAFPTPIPTSPTNETIITSKYMMVTARMDSFGMIPEISVGEVSVLTSIISVLAAARSMGTQIEKWQKASNTSNRNVFFAFFNGESLD-YIGSGAAAYQMENGKFPQMIRSDRTHIHPIRPNELDYILEVQQIGVAKGRKYYVHVDGERYQQNKTQTDRVIDRI</CrossRefSeq>
        <OrigSeq>RLLSFCVLLAGL-CRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWV------LTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAV-----SLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLG----NGLAYEDFSFPIFLLEDENETKVIKQET-------------FDYIGSSRMVYDM---------EKGKFPVQL--ENVDSFVELGQVALRTSLELWMHTDPV--SQKNESVRNQVEDLLATLEKSGAGVPAVILRRPN---------QSQPLPPSSLQRFLRARNIS--GVVLADHSGAFHNKYYQSIYDTAENINVSYPEWL-SPEEDLNFVT----DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NICA_ARATH">
      <Alignment>
        <CrossRefSeq>VLTGETWGYLGSRRFLHELDLHSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVS----SVTNMTLDALKIAQDSLASKNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLSNIN</CrossRefSeq>
        <OrigSeq>VIKQETFDYIGSSRMVYDMEKGKFPVQL---ENVDSFVELGQVALRTS---LELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRAR-NISGVVLADHSGAFHNKYYQSIYDTAENIN</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="500" CheckSum="e75fc44df268315d8def97ad261e5724">
    <Seq>
      MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC
      VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES
      KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN
      SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQETFDYI
      GSSRMVYDME KGKFPVQLEN VDSFVELGQV ALRTSLELWM HTDPVSQKNE
      SVRNQVEDLL ATLEKSGAGV PAVILRRPNQ SQPLPPSSLQ RFLRARNISG
      VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA
      DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL
      RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD
      PSKVPSENKD LITLTVGFGI LIFSLIVTYC INAKADVLFI APREPGAVSY
      
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="59.21">
    <Region from="1" to="33" loc="S"/>
    <Region from="34" to="459" loc="O"/>
    <Region from="460" to="480" loc="M"/>
    <Region from="481" to="500" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="33" loc="S"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="461" loc="I"/>
      <Region from="462" to="481" loc="M"/>
      <Region from="482" to="500" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="347" loc="I"/>
      <Region from="348" to="368" loc="M"/>
      <Region from="369" to="382" loc="O"/>
      <Region from="383" to="387" loc="L"/>
      <Region from="388" to="412" loc="O"/>
      <Region from="413" to="416" loc="L"/>
      <Region from="417" to="420" loc="O"/>
      <Region from="421" to="441" loc="M"/>
      <Region from="442" to="460" loc="I"/>
      <Region from="461" to="481" loc="M"/>
      <Region from="482" to="488" loc="O"/>
      <Region from="489" to="493" loc="L"/>
      <Region from="494" to="500" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="O"/>
      <Region from="461" to="483" loc="M"/>
      <Region from="484" to="500" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="O"/>
      <Region from="461" to="481" loc="M"/>
      <Region from="482" to="500" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="I"/>
      <Region from="461" to="481" loc="M"/>
      <Region from="482" to="500" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="459" loc="I"/>
      <Region from="460" to="481" loc="M"/>
      <Region from="482" to="500" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="O"/>
      <Region from="461" to="480" loc="M"/>
      <Region from="481" to="500" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="I"/>
      <Region from="461" to="481" loc="M"/>
      <Region from="482" to="500" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region from="1" to="33" loc="S"/>
      <Region from="1" to="33" loc="S"/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="33" loc="S"/>
      <Region from="34" to="460" loc="O"/>
      <Region from="461" to="483" loc="M"/>
      <Region from="484" to="500" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
