<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="S18B1_HUMAN" transmembrane="yes" evidence="3D">
  <Name>MFS-type transporter SLC18B1</Name>
  <CrossRef>
    <PDBTM id="8wlj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8zms">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wll">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wlk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8xo9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8xob">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8xoa">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wlm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgi">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tgg">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8t6a">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8t6b">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgn">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tgl">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgm">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8jsx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8t69">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jsw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jt9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jt5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgh">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgj">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8tgk">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8thr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jta">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7lo7">
      <Chain id="Z"/>
    </PDBTM>
    <TOPDB id="VACHT_RAT">
      <Alignment>
        <CrossRefSeq>IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFA-------EDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL-QWLYGALGLAVIGVSSCV--VPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHV-------SVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQ</CrossRefSeq>
        <OrigSeq>IGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNN--VATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESD-------PGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VMAT2_RAT">
      <Alignment>
        <CrossRefSeq>NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSY-------AFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR---WLCALLGMVIVGISIL--CIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHV-------SVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMA</CrossRefSeq>
        <OrigSeq>NTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFP--NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDP---GEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="456" CheckSum="ff04e3491bb116c1670d2bff03e1d82d">
    <Seq>
      MEALGDLEGP RAPGGDDPAG SAGETPGWLS REQVFVLISA ASVNLGSMMC
      YSILGPFFPK EAEKKGASNT IIGMIFGCFA LFELLASLVF GNYLVHIGAK
      FMFVAGMFVS GGVTILFGVL DRVPDGPVFI AMCFLVRVMD AVSFAAAMTA
      SSSILAKAFP NNVATVLGSL ETFSGLGLIL GPPVGGFLYQ SFGYEVPFIV
      LGCVVLLMVP LNMYILPNYE SDPGEHSFWK LIALPKVGLI AFVINSLSSC
      FGFLDPTLSL FVLEKFNLPA GYVGLVFLGM ALSYAISSPL FGLLSDKRPP
      LRKWLLVFGN LITAGCYMLL GPVPILHIKS QLWLLVLILV VSGLSAGMSI
      IPTFPEILSC AHENGFEEGL STLGLVSGLF SAMWSIGAFM GPTLGGFLYE
      KIGFEWAAAI QGLWALISGL AMGLFYLLEY SRRKRSKSQN ILSTEEERTT
      LLPNET
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="84.73">
    <Region from="1" to="33" loc="I"/>
    <Region from="34" to="54" loc="M"/>
    <Region from="55" to="69" loc="O"/>
    <Region from="70" to="90" loc="M"/>
    <Region from="91" to="100" loc="I"/>
    <Region from="101" to="120" loc="M"/>
    <Region from="121" to="127" loc="O"/>
    <Region from="128" to="148" loc="M"/>
    <Region from="149" to="161" loc="I"/>
    <Region from="162" to="181" loc="M"/>
    <Region from="182" to="194" loc="O"/>
    <Region from="195" to="215" loc="M"/>
    <Region from="216" to="231" loc="I"/>
    <Region from="232" to="253" loc="M"/>
    <Region from="254" to="271" loc="O"/>
    <Region from="272" to="293" loc="M"/>
    <Region from="294" to="303" loc="I"/>
    <Region from="304" to="323" loc="M"/>
    <Region from="324" to="331" loc="O"/>
    <Region from="332" to="351" loc="M"/>
    <Region from="352" to="369" loc="I"/>
    <Region from="370" to="391" loc="M"/>
    <Region from="392" to="406" loc="O"/>
    <Region from="407" to="427" loc="M"/>
    <Region from="428" to="456" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="33" loc="I"/>
      <Region from="34" to="55" loc="M"/>
      <Region from="56" to="69" loc="O"/>
      <Region from="70" to="91" loc="M"/>
      <Region from="92" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="127" loc="O"/>
      <Region from="128" to="155" loc="M"/>
      <Region from="156" to="162" loc="I"/>
      <Region from="163" to="181" loc="M"/>
      <Region from="182" to="195" loc="O"/>
      <Region from="196" to="217" loc="M"/>
      <Region from="218" to="230" loc="I"/>
      <Region from="231" to="252" loc="M"/>
      <Region from="253" to="272" loc="O"/>
      <Region from="273" to="294" loc="M"/>
      <Region from="295" to="304" loc="I"/>
      <Region from="305" to="326" loc="M"/>
      <Region from="327" to="333" loc="O"/>
      <Region from="334" to="355" loc="M"/>
      <Region from="356" to="368" loc="I"/>
      <Region from="369" to="390" loc="M"/>
      <Region from="391" to="405" loc="O"/>
      <Region from="406" to="427" loc="M"/>
      <Region from="428" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="41" loc="O"/>
      <Region from="42" to="57" loc="M"/>
      <Region from="58" to="70" loc="I"/>
      <Region from="71" to="93" loc="M"/>
      <Region from="94" to="99" loc="O"/>
      <Region from="100" to="120" loc="M"/>
      <Region from="121" to="131" loc="I"/>
      <Region from="132" to="149" loc="M"/>
      <Region from="150" to="164" loc="O"/>
      <Region from="165" to="188" loc="M"/>
      <Region from="189" to="191" loc="I"/>
      <Region from="192" to="213" loc="M"/>
      <Region from="214" to="232" loc="O"/>
      <Region from="233" to="256" loc="M"/>
      <Region from="257" to="271" loc="I"/>
      <Region from="272" to="291" loc="M"/>
      <Region from="292" to="303" loc="O"/>
      <Region from="304" to="326" loc="M"/>
      <Region from="327" to="331" loc="I"/>
      <Region from="332" to="358" loc="M"/>
      <Region from="359" to="376" loc="O"/>
      <Region from="377" to="399" loc="M"/>
      <Region from="400" to="402" loc="I"/>
      <Region from="403" to="427" loc="M"/>
      <Region from="428" to="456" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="30" loc="I"/>
      <Region from="31" to="51" loc="M"/>
      <Region from="52" to="69" loc="O"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="98" loc="I"/>
      <Region from="99" to="119" loc="M"/>
      <Region from="120" to="132" loc="O"/>
      <Region from="133" to="153" loc="M"/>
      <Region from="154" to="165" loc="I"/>
      <Region from="166" to="186" loc="M"/>
      <Region from="187" to="194" loc="O"/>
      <Region from="195" to="215" loc="M"/>
      <Region from="216" to="233" loc="I"/>
      <Region from="234" to="254" loc="M"/>
      <Region from="255" to="270" loc="O"/>
      <Region from="271" to="291" loc="M"/>
      <Region from="292" to="303" loc="I"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="333" loc="O"/>
      <Region from="334" to="354" loc="M"/>
      <Region from="355" to="370" loc="I"/>
      <Region from="371" to="401" loc="M"/>
      <Region from="402" to="402" loc="O"/>
      <Region from="403" to="423" loc="M"/>
      <Region from="424" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="33" loc="I"/>
      <Region from="34" to="55" loc="M"/>
      <Region from="56" to="69" loc="O"/>
      <Region from="70" to="91" loc="M"/>
      <Region from="92" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="127" loc="O"/>
      <Region from="128" to="150" loc="M"/>
      <Region from="151" to="162" loc="I"/>
      <Region from="163" to="181" loc="M"/>
      <Region from="182" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="231" loc="I"/>
      <Region from="232" to="254" loc="M"/>
      <Region from="255" to="269" loc="O"/>
      <Region from="270" to="294" loc="M"/>
      <Region from="295" to="303" loc="I"/>
      <Region from="304" to="326" loc="M"/>
      <Region from="327" to="331" loc="O"/>
      <Region from="332" to="354" loc="M"/>
      <Region from="355" to="369" loc="I"/>
      <Region from="370" to="391" loc="M"/>
      <Region from="392" to="406" loc="O"/>
      <Region from="407" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="33" loc="I"/>
      <Region from="34" to="58" loc="M"/>
      <Region from="59" to="69" loc="O"/>
      <Region from="70" to="94" loc="M"/>
      <Region from="95" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="125" loc="O"/>
      <Region from="126" to="150" loc="M"/>
      <Region from="151" to="161" loc="I"/>
      <Region from="162" to="184" loc="M"/>
      <Region from="185" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="227" loc="I"/>
      <Region from="228" to="254" loc="M"/>
      <Region from="255" to="273" loc="O"/>
      <Region from="274" to="293" loc="M"/>
      <Region from="294" to="304" loc="I"/>
      <Region from="305" to="326" loc="M"/>
      <Region from="327" to="331" loc="O"/>
      <Region from="332" to="351" loc="M"/>
      <Region from="352" to="371" loc="I"/>
      <Region from="372" to="394" loc="M"/>
      <Region from="395" to="405" loc="O"/>
      <Region from="406" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="33" loc="I"/>
      <Region from="34" to="54" loc="M"/>
      <Region from="55" to="70" loc="O"/>
      <Region from="71" to="91" loc="M"/>
      <Region from="92" to="100" loc="I"/>
      <Region from="101" to="121" loc="M"/>
      <Region from="122" to="125" loc="O"/>
      <Region from="126" to="146" loc="M"/>
      <Region from="147" to="166" loc="I"/>
      <Region from="167" to="187" loc="M"/>
      <Region from="188" to="191" loc="O"/>
      <Region from="192" to="212" loc="M"/>
      <Region from="213" to="232" loc="I"/>
      <Region from="233" to="253" loc="M"/>
      <Region from="254" to="273" loc="O"/>
      <Region from="274" to="294" loc="M"/>
      <Region from="295" to="305" loc="I"/>
      <Region from="306" to="326" loc="M"/>
      <Region from="327" to="330" loc="O"/>
      <Region from="331" to="351" loc="M"/>
      <Region from="352" to="371" loc="I"/>
      <Region from="372" to="392" loc="M"/>
      <Region from="393" to="407" loc="O"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="34" loc="I"/>
      <Region from="35" to="55" loc="M"/>
      <Region from="56" to="70" loc="O"/>
      <Region from="71" to="91" loc="M"/>
      <Region from="92" to="102" loc="I"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="127" loc="O"/>
      <Region from="128" to="148" loc="M"/>
      <Region from="149" to="159" loc="I"/>
      <Region from="160" to="180" loc="M"/>
      <Region from="181" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="236" loc="I"/>
      <Region from="237" to="257" loc="M"/>
      <Region from="258" to="272" loc="O"/>
      <Region from="273" to="293" loc="M"/>
      <Region from="294" to="304" loc="I"/>
      <Region from="305" to="325" loc="M"/>
      <Region from="326" to="330" loc="O"/>
      <Region from="331" to="351" loc="M"/>
      <Region from="352" to="371" loc="I"/>
      <Region from="372" to="392" loc="M"/>
      <Region from="393" to="407" loc="O"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="99" loc="O"/>
      <Region from="100" to="119" loc="M"/>
      <Region from="120" to="127" loc="I"/>
      <Region from="128" to="147" loc="M"/>
      <Region from="148" to="195" loc="O"/>
      <Region from="196" to="215" loc="M"/>
      <Region from="216" to="227" loc="I"/>
      <Region from="228" to="247" loc="M"/>
      <Region from="248" to="265" loc="O"/>
      <Region from="266" to="285" loc="M"/>
      <Region from="286" to="300" loc="I"/>
      <Region from="301" to="320" loc="M"/>
      <Region from="321" to="330" loc="O"/>
      <Region from="331" to="350" loc="M"/>
      <Region from="351" to="369" loc="I"/>
      <Region from="370" to="389" loc="M"/>
      <Region from="390" to="407" loc="O"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="33" loc="I"/>
      <Region from="34" to="54" loc="M"/>
      <Region from="55" to="73" loc="O"/>
      <Region from="74" to="94" loc="M"/>
      <Region from="95" to="100" loc="I"/>
      <Region from="101" to="121" loc="M"/>
      <Region from="122" to="122" loc="O"/>
      <Region from="123" to="143" loc="M"/>
      <Region from="144" to="168" loc="I"/>
      <Region from="169" to="189" loc="M"/>
      <Region from="190" to="192" loc="O"/>
      <Region from="193" to="213" loc="M"/>
      <Region from="214" to="237" loc="I"/>
      <Region from="238" to="258" loc="M"/>
      <Region from="259" to="270" loc="O"/>
      <Region from="271" to="291" loc="M"/>
      <Region from="292" to="303" loc="I"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="331" loc="O"/>
      <Region from="332" to="352" loc="M"/>
      <Region from="353" to="385" loc="I"/>
      <Region from="386" to="406" loc="M"/>
      <Region from="407" to="407" loc="O"/>
      <Region from="408" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="34" loc="I"/>
      <Region from="35" to="57" loc="M"/>
      <Region from="58" to="71" loc="O"/>
      <Region from="72" to="94" loc="M"/>
      <Region from="95" to="100" loc="I"/>
      <Region from="101" to="123" loc="M"/>
      <Region from="124" to="132" loc="O"/>
      <Region from="133" to="155" loc="M"/>
      <Region from="156" to="161" loc="I"/>
      <Region from="162" to="184" loc="M"/>
      <Region from="185" to="193" loc="O"/>
      <Region from="194" to="216" loc="M"/>
      <Region from="217" to="236" loc="I"/>
      <Region from="237" to="259" loc="M"/>
      <Region from="260" to="271" loc="O"/>
      <Region from="272" to="294" loc="M"/>
      <Region from="295" to="305" loc="I"/>
      <Region from="306" to="328" loc="M"/>
      <Region from="329" to="331" loc="O"/>
      <Region from="332" to="354" loc="M"/>
      <Region from="355" to="373" loc="I"/>
      <Region from="374" to="396" loc="M"/>
      <Region from="397" to="405" loc="O"/>
      <Region from="406" to="428" loc="M"/>
      <Region from="429" to="456" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8tgm_A">
      <ConstraintRegion from="18" to="26" loc="I" subId="20949573" subSource="8tgm_A"/>
      <ConstraintRegion from="27" to="44" loc="H" subId="20949574" subSource="8tgm_A"/>
      <ConstraintRegion from="45" to="54" loc="O" subId="20949575" subSource="8tgm_A"/>
      <ConstraintRegion from="127" to="140" loc="O" subId="20949577" subSource="8tgm_A"/>
      <ConstraintRegion from="141" to="157" loc="H" subId="20949578" subSource="8tgm_A"/>
      <ConstraintRegion from="158" to="169" loc="I" subId="20949579" subSource="8tgm_A"/>
      <ConstraintRegion from="170" to="187" loc="H" subId="20949580" subSource="8tgm_A"/>
      <ConstraintRegion from="188" to="191" loc="O" subId="20949581" subSource="8tgm_A"/>
      <ConstraintRegion from="192" to="209" loc="H" subId="20949582" subSource="8tgm_A"/>
      <ConstraintRegion from="210" to="232" loc="I" subId="20949583" subSource="8tgm_A"/>
      <ConstraintRegion from="233" to="250" loc="H" subId="20949584" subSource="8tgm_A"/>
      <ConstraintRegion from="251" to="256" loc="O" subId="20949585" subSource="8tgm_A"/>
      <ConstraintRegion from="257" to="274" loc="H" subId="20949586" subSource="8tgm_A"/>
      <ConstraintRegion from="275" to="278" loc="I" subId="20949587" subSource="8tgm_A"/>
      <ConstraintRegion from="289" to="300" loc="I" subId="20949589" subSource="8tgm_A"/>
      <ConstraintRegion from="301" to="321" loc="H" subId="20949590" subSource="8tgm_A"/>
      <ConstraintRegion from="322" to="339" loc="O" subId="20949591" subSource="8tgm_A"/>
      <ConstraintRegion from="340" to="360" loc="H" subId="20949592" subSource="8tgm_A"/>
      <ConstraintRegion from="361" to="363" loc="I" subId="20949593" subSource="8tgm_A"/>
      <ConstraintRegion from="364" to="383" loc="H" subId="20949594" subSource="8tgm_A"/>
      <ConstraintRegion from="384" to="392" loc="O" subId="20949595" subSource="8tgm_A"/>
      <ConstraintRegion from="393" to="411" loc="H" subId="20949596" subSource="8tgm_A"/>
      <ConstraintRegion from="412" to="430" loc="I" subId="20949597" subSource="8tgm_A"/>
      <ConstraintRegion from="431" to="448" loc="H" subId="20949598" subSource="8tgm_A"/>
      <ConstraintRegion from="449" to="461" loc="O" subId="20949599" subSource="8tgm_A"/>
      <ConstraintRegion from="462" to="478" loc="H" subId="20949600" subSource="8tgm_A"/>
      <ConstraintRegion from="479" to="483" loc="I" subId="20949601" subSource="8tgm_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
