<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="TMC5_HUMAN" transmembrane="yes" evidence="Prediction">
  <Name>Transmembrane channel-like protein 5</Name>
  <CrossRef>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>ENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLA--QYSVLFYGYYDN---KRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEER--AAQVEENIHLIRFL-RFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYH-PLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVL-YMIVSLPPSFDCGPFSGKNRMFEVIGETLEH----DFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLN-ATAKGQKAANLDLKKKMKQQALENKMRNKKM</CrossRefSeq>
        <OrigSeq>TSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRA--YRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKK---------------NTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSN---PGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVA----------------------------------------------LSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLR----RIIGMQLITSLGLQ-----EFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>WAIMQCGTLKGEHFFAQN--ATAITISLITLVFPNIFDLLGKIEKLHPRNALRFQLGRVLVLYILNYYTLIYSLMLQLEHLQKEKNASDNPISA----LGHPGDAIGRTIRETVLPRYPV-----DNNPHTYYSYAPVTTTPIPATSSW--TTVLPDFGPFGVYNPKASVTKDDTVFSS---------PVVETHMFGPNSDWNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLF---LCTLPVGFVIASKTPSKSCGPFGNQS-FFYSVIT--DVLHENLDKTLVNGIKYSLSPGI-IIPVLVLLSLVIYFLIAMVT-GLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVSSDDDSQHNRSTAKSVSGRQFVP</CrossRefSeq>
        <OrigSeq>YGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHI------YSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALS---GEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIG--MQLITSLGLQ-------EFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAI--TIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="1006" CheckSum="320451e38aed43b36e539f04f0f5cc52">
    <Seq>
      MSAYYRNNWS EEDPDYPDYS GSQNRTQGYL KTQGYPDVPG PLNNPDYPGT
      RSNPYSVASR TRPDYPGSLA EPNYPRSLSN PDYSGTRSNA YSAASRTSPD
      HPTSLPEPDY SEFQSHPYHR ASSRQPDYPG SQRNPDFAGS SSSGNYAGSR
      THPDHFGSLE PDYPGAQSNS DHPGPRANLN HPGSRKNLEH TSFRINPYAD
      SLGKPDYPGA DIQPNSPPFF GEPDYPSAED NQNLPSTWRE PDYSDAENGH
      DYGSSETPKM TRGVLSRTSS IQPSFRHRSD DPVGSLWGEN DYPEGIEMAS
      MEMANSYGHS LPGAPGSGYV NPAYVGESGP VHAYGNPPLS ECDWHKSPQG
      QKLIASLIPM TSRDRIKAIR NQPRTMEEKR NLRKIVDKEK SKQTHRILQL
      NCCIQCLNSI SRAYRRSKNS LSEILNSISL WQKTLKIIGG KFGTSVLSYF
      NFLRWLLKFN IFSFILNFSF IIIPQFTVAK KNTLQFTGLE FFTGVGYFRD
      TVMYYGFYTN STIQHGNSGA SYNMQLAYIF TIGACLTTCF FSLLFSMAKY
      FRNNFINPHI YSGGITKLIF CWDFTVTHEK AVKLKQKNLS TEIRENLSEL
      RQENSKLTFN QLLTRFSAYM VAWVVSTGVA IACCAAVYYL AEYNLEFLKT
      HSNPGAVLLL PFVVSCINLA VPCIYSMFRL VERYEMPRHE VYVLLIRNIF
      LKISIIGILC YYWLNTVALS GEECWETLIG QDIYRLLLMD FVFSLVNSFL
      GEFLRRIIGM QLITSLGLQE FDIARNVLEL IYAQTLVWIG IFFCPLLPFI
      QMIMLFIMFY SKNISLMMNF QPPSKAWRAS QMMTFFIFLL FFPSFTGVLC
      TLAITIWRLK PSADCGPFRG LPLFIHSIYS WIDTLSTRPG YLWVVWIYRN
      LIGSVHFFFI LTLIVLIITY LYWQITEGRK IMIRLLHEQI INEGKDKMFL
      IEKLIKLQDM EKKANPSSLV LERREVEQQG FLHLGEHDGS LDLRSRRSVQ
      EGNPRA
    </Seq>
  </Sequence>
  <Topology numTm="10" reliability="73.76">
    <Region from="1" to="445" loc="I"/>
    <Region from="446" to="473" loc="M"/>
    <Region from="474" to="525" loc="O"/>
    <Region from="526" to="545" loc="M"/>
    <Region from="546" to="617" loc="I"/>
    <Region from="618" to="638" loc="M"/>
    <Region from="639" to="654" loc="O"/>
    <Region from="655" to="676" loc="M"/>
    <Region from="677" to="692" loc="I"/>
    <Region from="693" to="714" loc="M"/>
    <Region from="715" to="735" loc="O"/>
    <Region from="736" to="754" loc="M"/>
    <Region from="755" to="784" loc="I"/>
    <Region from="785" to="809" loc="M"/>
    <Region from="810" to="832" loc="O"/>
    <Region from="833" to="856" loc="M"/>
    <Region from="857" to="863" loc="I"/>
    <Region from="864" to="875" loc="M"/>
    <Region from="876" to="900" loc="O"/>
    <Region from="901" to="922" loc="M"/>
    <Region from="923" to="1006" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="441" loc="I"/>
      <Region from="442" to="457" loc="M"/>
      <Region from="458" to="526" loc="O"/>
      <Region from="527" to="548" loc="M"/>
      <Region from="549" to="619" loc="I"/>
      <Region from="620" to="641" loc="M"/>
      <Region from="642" to="655" loc="O"/>
      <Region from="656" to="672" loc="M"/>
      <Region from="673" to="702" loc="I"/>
      <Region from="703" to="719" loc="M"/>
      <Region from="720" to="735" loc="O"/>
      <Region from="736" to="754" loc="M"/>
      <Region from="755" to="784" loc="I"/>
      <Region from="785" to="806" loc="M"/>
      <Region from="807" to="834" loc="O"/>
      <Region from="835" to="856" loc="M"/>
      <Region from="857" to="869" loc="I"/>
      <Region from="870" to="885" loc="M"/>
      <Region from="886" to="900" loc="O"/>
      <Region from="901" to="922" loc="M"/>
      <Region from="923" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="445" loc="I"/>
      <Region from="446" to="475" loc="M"/>
      <Region from="476" to="522" loc="O"/>
      <Region from="523" to="547" loc="M"/>
      <Region from="548" to="613" loc="I"/>
      <Region from="614" to="641" loc="M"/>
      <Region from="642" to="657" loc="O"/>
      <Region from="658" to="676" loc="M"/>
      <Region from="677" to="693" loc="I"/>
      <Region from="694" to="714" loc="M"/>
      <Region from="715" to="734" loc="O"/>
      <Region from="735" to="759" loc="M"/>
      <Region from="760" to="778" loc="I"/>
      <Region from="779" to="800" loc="M"/>
      <Region from="801" to="803" loc="O"/>
      <Region from="804" to="819" loc="M"/>
      <Region from="820" to="833" loc="I"/>
      <Region from="834" to="857" loc="M"/>
      <Region from="858" to="899" loc="O"/>
      <Region from="900" to="925" loc="M"/>
      <Region from="926" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="444" loc="O"/>
      <Region from="445" to="475" loc="M"/>
      <Region from="476" to="487" loc="I"/>
      <Region from="488" to="508" loc="M"/>
      <Region from="509" to="521" loc="O"/>
      <Region from="522" to="542" loc="M"/>
      <Region from="543" to="616" loc="I"/>
      <Region from="617" to="637" loc="M"/>
      <Region from="638" to="655" loc="O"/>
      <Region from="656" to="676" loc="M"/>
      <Region from="677" to="691" loc="I"/>
      <Region from="692" to="712" loc="M"/>
      <Region from="713" to="736" loc="O"/>
      <Region from="737" to="757" loc="M"/>
      <Region from="758" to="778" loc="I"/>
      <Region from="779" to="793" loc="M"/>
      <Region from="794" to="794" loc="O"/>
      <Region from="795" to="809" loc="M"/>
      <Region from="810" to="832" loc="I"/>
      <Region from="833" to="853" loc="M"/>
      <Region from="854" to="894" loc="O"/>
      <Region from="895" to="925" loc="M"/>
      <Region from="926" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="454" loc="O"/>
      <Region from="455" to="478" loc="M"/>
      <Region from="479" to="485" loc="I"/>
      <Region from="486" to="503" loc="M"/>
      <Region from="504" to="525" loc="O"/>
      <Region from="526" to="546" loc="M"/>
      <Region from="547" to="618" loc="I"/>
      <Region from="619" to="641" loc="M"/>
      <Region from="642" to="656" loc="O"/>
      <Region from="657" to="678" loc="M"/>
      <Region from="679" to="693" loc="I"/>
      <Region from="694" to="715" loc="M"/>
      <Region from="716" to="732" loc="O"/>
      <Region from="733" to="754" loc="M"/>
      <Region from="755" to="784" loc="I"/>
      <Region from="785" to="810" loc="M"/>
      <Region from="811" to="833" loc="O"/>
      <Region from="834" to="857" loc="M"/>
      <Region from="858" to="864" loc="I"/>
      <Region from="865" to="885" loc="M"/>
      <Region from="886" to="901" loc="O"/>
      <Region from="902" to="924" loc="M"/>
      <Region from="925" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="454" loc="O"/>
      <Region from="455" to="474" loc="M"/>
      <Region from="475" to="485" loc="I"/>
      <Region from="486" to="507" loc="M"/>
      <Region from="508" to="526" loc="O"/>
      <Region from="527" to="545" loc="M"/>
      <Region from="546" to="615" loc="I"/>
      <Region from="616" to="641" loc="M"/>
      <Region from="642" to="655" loc="O"/>
      <Region from="656" to="678" loc="M"/>
      <Region from="679" to="689" loc="I"/>
      <Region from="690" to="714" loc="M"/>
      <Region from="715" to="733" loc="O"/>
      <Region from="734" to="754" loc="M"/>
      <Region from="755" to="784" loc="I"/>
      <Region from="785" to="810" loc="M"/>
      <Region from="811" to="829" loc="O"/>
      <Region from="830" to="854" loc="M"/>
      <Region from="855" to="865" loc="I"/>
      <Region from="866" to="882" loc="M"/>
      <Region from="883" to="901" loc="O"/>
      <Region from="902" to="923" loc="M"/>
      <Region from="924" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="458" loc="I"/>
      <Region from="459" to="479" loc="M"/>
      <Region from="480" to="527" loc="O"/>
      <Region from="528" to="548" loc="M"/>
      <Region from="549" to="620" loc="I"/>
      <Region from="621" to="641" loc="M"/>
      <Region from="642" to="656" loc="O"/>
      <Region from="657" to="677" loc="M"/>
      <Region from="678" to="697" loc="I"/>
      <Region from="698" to="718" loc="M"/>
      <Region from="719" to="738" loc="O"/>
      <Region from="739" to="759" loc="M"/>
      <Region from="760" to="779" loc="I"/>
      <Region from="780" to="800" loc="M"/>
      <Region from="801" to="836" loc="O"/>
      <Region from="837" to="857" loc="M"/>
      <Region from="858" to="877" loc="I"/>
      <Region from="878" to="898" loc="M"/>
      <Region from="899" to="902" loc="O"/>
      <Region from="903" to="923" loc="M"/>
      <Region from="924" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="433" loc="I"/>
      <Region from="434" to="454" loc="M"/>
      <Region from="455" to="458" loc="O"/>
      <Region from="459" to="479" loc="M"/>
      <Region from="480" to="484" loc="I"/>
      <Region from="485" to="505" loc="M"/>
      <Region from="506" to="525" loc="O"/>
      <Region from="526" to="546" loc="M"/>
      <Region from="547" to="619" loc="I"/>
      <Region from="620" to="640" loc="M"/>
      <Region from="641" to="656" loc="O"/>
      <Region from="657" to="677" loc="M"/>
      <Region from="678" to="695" loc="I"/>
      <Region from="696" to="716" loc="M"/>
      <Region from="717" to="736" loc="O"/>
      <Region from="737" to="757" loc="M"/>
      <Region from="758" to="790" loc="I"/>
      <Region from="791" to="811" loc="M"/>
      <Region from="812" to="831" loc="O"/>
      <Region from="832" to="852" loc="M"/>
      <Region from="853" to="863" loc="I"/>
      <Region from="864" to="884" loc="M"/>
      <Region from="885" to="904" loc="O"/>
      <Region from="905" to="925" loc="M"/>
      <Region from="926" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="451" loc="I"/>
      <Region from="452" to="472" loc="M"/>
      <Region from="473" to="525" loc="O"/>
      <Region from="526" to="545" loc="M"/>
      <Region from="546" to="617" loc="I"/>
      <Region from="618" to="637" loc="M"/>
      <Region from="638" to="654" loc="O"/>
      <Region from="655" to="674" loc="M"/>
      <Region from="675" to="698" loc="I"/>
      <Region from="699" to="718" loc="M"/>
      <Region from="719" to="733" loc="O"/>
      <Region from="734" to="753" loc="M"/>
      <Region from="754" to="773" loc="I"/>
      <Region from="774" to="793" loc="M"/>
      <Region from="794" to="795" loc="O"/>
      <Region from="796" to="815" loc="M"/>
      <Region from="816" to="831" loc="I"/>
      <Region from="832" to="851" loc="M"/>
      <Region from="852" to="904" loc="O"/>
      <Region from="905" to="925" loc="M"/>
      <Region from="926" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="452" loc="I"/>
      <Region from="453" to="473" loc="M"/>
      <Region from="474" to="523" loc="O"/>
      <Region from="524" to="544" loc="M"/>
      <Region from="545" to="612" loc="I"/>
      <Region from="613" to="633" loc="M"/>
      <Region from="634" to="654" loc="O"/>
      <Region from="655" to="675" loc="M"/>
      <Region from="676" to="693" loc="I"/>
      <Region from="694" to="714" loc="M"/>
      <Region from="715" to="732" loc="O"/>
      <Region from="733" to="753" loc="M"/>
      <Region from="754" to="776" loc="I"/>
      <Region from="777" to="797" loc="M"/>
      <Region from="798" to="798" loc="O"/>
      <Region from="799" to="819" loc="M"/>
      <Region from="820" to="834" loc="I"/>
      <Region from="835" to="855" loc="M"/>
      <Region from="856" to="905" loc="O"/>
      <Region from="906" to="926" loc="M"/>
      <Region from="927" to="1006" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="450" loc="O"/>
      <Region from="451" to="473" loc="M"/>
      <Region from="474" to="485" loc="I"/>
      <Region from="486" to="508" loc="M"/>
      <Region from="509" to="522" loc="O"/>
      <Region from="523" to="545" loc="M"/>
      <Region from="546" to="618" loc="I"/>
      <Region from="619" to="641" loc="M"/>
      <Region from="642" to="655" loc="O"/>
      <Region from="656" to="678" loc="M"/>
      <Region from="679" to="690" loc="I"/>
      <Region from="691" to="713" loc="M"/>
      <Region from="714" to="786" loc="O"/>
      <Region from="787" to="809" loc="M"/>
      <Region from="810" to="834" loc="I"/>
      <Region from="835" to="857" loc="M"/>
      <Region from="858" to="900" loc="O"/>
      <Region from="901" to="923" loc="M"/>
      <Region from="924" to="1006" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
