<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="TMTC2_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Protein O-mannosyl-transferase TMTC2 </Name>
  <CrossRef>
    <PDBTM id="6b85">
      <Chain id="J"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="I"/>
      <Chain id="K"/>
      <Chain id="L"/>
      <Chain id="M"/>
      <Chain id="N"/>
      <Chain id="O"/>
      <Chain id="P"/>
    </PDBTM>
    <PDBTM id="6vfk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vfh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vfi">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f9i">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="TMTC3_HUMAN">
      <Alignment>
        <CrossRefSeq>TVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKS---VFKKLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNK--------------------------------NNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFK---QAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLIL---KGDILMNQK</CrossRefSeq>
        <OrigSeq>IVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSV---TSCLYNLGKLYH-EQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEA-EKLFLKAIELDPTKGNCYMHYGQFLLEEARL---IEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FICD_HUMAN">
      <Alignment>
        <CrossRefSeq>ALEMKRQGKREKAQ-KLFMHALKMDPDFVDALTEFGIFSEEDKDIIQADYLYTRALTISPYHEKALVNRDRTLPLVEE</CrossRefSeq>
        <OrigSeq>AAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEK</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="836" CheckSum="98c25a4440bf41ee5bbed6ae859aee3f">
    <Seq>
      MIAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND
      FWGTLLTHSG SHKSYRPLCT LSFRLNHAIG GLNPWSYHLV NVLLHAAVTG
      LFTSFSKILL GDGYWTFMAG LMFASHPIHT EAVAGIVGRA DVGASLFFLL
      SLLCYIKHCS TRGYSARTWG WFLGSGLCAG CSMLWKEQGV TVLAVSAVYD
      VFVFHRLKIK QILPTIYKRK NLSLFLSISL LIFWGSSLLG ARLYWMGNKP
      PSFSNSDNPA ADSDSLLTRT LTFFYLPTKN LWLLLCPDTL SFDWSMDAVP
      LLKTVCDWRN LHTVAFYTGL LLLAYYGLKS PSVDRECNGK TVTNGKQNAN
      GHSCLSDVEY QNSETKSSFA SKVENGIKND VSQRTQLPST ENIVVLSLSL
      LIIPFVPATN LFFYVGFVIA ERVLYIPSMG FCLLITVGAR ALYVKVQKRF
      LKSLIFYATA TLIVFYGLKT AIRNGDWQNE EMLYRSGIKV NPAKAWGNLG
      NVLKSQSKIS EAESAYRNAL YYRSNMADML YNLGLLLQEN SRFAEALHYY
      KLAIGSRPTL ASAYLNTGII LMNQGRTEEA RRTFLKCSEI PDENLKDPHA
      HKSSVTSCLY NLGKLYHEQG HYEEALSVYK EAIQKMPRQF APQSLYNMMG
      EAYMRLSKLP EAEHWYMESL RSKTDHIPAH LTYGKLLALT GRKSEAEKLF
      LKAIELDPTK GNCYMHYGQF LLEEARLIEA AEMAKKAAEL DSTEFDVVFN
      AAHMLRQASL NEAAEKYYDL AARLRPNYPA ALMNLGAILH LNGRLQKAEA
      NYLRALQLKP DDVITQSNLR KLWNIMEKQG LKTSKT
    </Seq>
  </Sequence>
  <Topology numTm="10" reliability="78">
    <Region from="1" to="21" loc="S"/>
    <Region from="22" to="88" loc="O"/>
    <Region from="89" to="105" loc="M"/>
    <Region from="106" to="107" loc="I"/>
    <Region from="108" to="124" loc="M"/>
    <Region from="125" to="133" loc="O"/>
    <Region from="134" to="154" loc="M"/>
    <Region from="155" to="167" loc="I"/>
    <Region from="168" to="184" loc="M"/>
    <Region from="185" to="188" loc="O"/>
    <Region from="189" to="204" loc="M"/>
    <Region from="205" to="220" loc="I"/>
    <Region from="221" to="241" loc="M"/>
    <Region from="242" to="310" loc="O"/>
    <Region from="311" to="328" loc="M"/>
    <Region from="329" to="392" loc="I"/>
    <Region from="393" to="413" loc="M"/>
    <Region from="414" to="422" loc="O"/>
    <Region from="423" to="442" loc="M"/>
    <Region from="443" to="449" loc="I"/>
    <Region from="450" to="468" loc="M"/>
    <Region from="469" to="836" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="89" loc="O"/>
      <Region from="90" to="105" loc="M"/>
      <Region from="106" to="107" loc="I"/>
      <Region from="108" to="123" loc="M"/>
      <Region from="124" to="139" loc="O"/>
      <Region from="140" to="155" loc="M"/>
      <Region from="156" to="169" loc="I"/>
      <Region from="170" to="185" loc="M"/>
      <Region from="186" to="188" loc="O"/>
      <Region from="189" to="204" loc="M"/>
      <Region from="205" to="223" loc="I"/>
      <Region from="224" to="239" loc="M"/>
      <Region from="240" to="392" loc="O"/>
      <Region from="393" to="408" loc="M"/>
      <Region from="409" to="410" loc="I"/>
      <Region from="411" to="426" loc="M"/>
      <Region from="427" to="428" loc="O"/>
      <Region from="429" to="444" loc="M"/>
      <Region from="445" to="452" loc="I"/>
      <Region from="453" to="468" loc="M"/>
      <Region from="469" to="836" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="86" loc="O"/>
      <Region from="87" to="111" loc="M"/>
      <Region from="112" to="114" loc="I"/>
      <Region from="115" to="130" loc="M"/>
      <Region from="131" to="133" loc="O"/>
      <Region from="134" to="156" loc="M"/>
      <Region from="157" to="169" loc="I"/>
      <Region from="170" to="185" loc="M"/>
      <Region from="186" to="188" loc="O"/>
      <Region from="189" to="204" loc="M"/>
      <Region from="205" to="222" loc="I"/>
      <Region from="223" to="243" loc="M"/>
      <Region from="244" to="270" loc="O"/>
      <Region from="271" to="293" loc="M"/>
      <Region from="294" to="310" loc="I"/>
      <Region from="311" to="330" loc="M"/>
      <Region from="331" to="390" loc="O"/>
      <Region from="391" to="409" loc="M"/>
      <Region from="410" to="412" loc="I"/>
      <Region from="413" to="440" loc="M"/>
      <Region from="441" to="452" loc="O"/>
      <Region from="453" to="468" loc="M"/>
      <Region from="469" to="836" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="74" loc="I"/>
      <Region from="75" to="89" loc="M"/>
      <Region from="90" to="90" loc="O"/>
      <Region from="91" to="105" loc="M"/>
      <Region from="106" to="111" loc="I"/>
      <Region from="112" to="132" loc="M"/>
      <Region from="133" to="133" loc="O"/>
      <Region from="134" to="154" loc="M"/>
      <Region from="155" to="165" loc="I"/>
      <Region from="166" to="186" loc="M"/>
      <Region from="187" to="187" loc="O"/>
      <Region from="188" to="208" loc="M"/>
      <Region from="209" to="221" loc="I"/>
      <Region from="222" to="242" loc="M"/>
      <Region from="243" to="264" loc="O"/>
      <Region from="265" to="279" loc="M"/>
      <Region from="280" to="280" loc="I"/>
      <Region from="281" to="295" loc="M"/>
      <Region from="296" to="308" loc="O"/>
      <Region from="309" to="329" loc="M"/>
      <Region from="330" to="387" loc="I"/>
      <Region from="388" to="408" loc="M"/>
      <Region from="409" to="409" loc="O"/>
      <Region from="410" to="440" loc="M"/>
      <Region from="441" to="449" loc="I"/>
      <Region from="450" to="470" loc="M"/>
      <Region from="471" to="836" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="88" loc="I"/>
      <Region from="89" to="111" loc="M"/>
      <Region from="112" to="134" loc="O"/>
      <Region from="135" to="156" loc="M"/>
      <Region from="157" to="167" loc="I"/>
      <Region from="168" to="185" loc="M"/>
      <Region from="186" to="189" loc="O"/>
      <Region from="190" to="209" loc="M"/>
      <Region from="210" to="221" loc="I"/>
      <Region from="222" to="245" loc="M"/>
      <Region from="246" to="309" loc="O"/>
      <Region from="310" to="328" loc="M"/>
      <Region from="329" to="392" loc="I"/>
      <Region from="393" to="415" loc="M"/>
      <Region from="416" to="422" loc="O"/>
      <Region from="423" to="444" loc="M"/>
      <Region from="445" to="452" loc="I"/>
      <Region from="453" to="472" loc="M"/>
      <Region from="473" to="836" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="84" loc="O"/>
      <Region from="85" to="106" loc="M"/>
      <Region from="107" to="112" loc="I"/>
      <Region from="113" to="130" loc="M"/>
      <Region from="131" to="135" loc="O"/>
      <Region from="136" to="156" loc="M"/>
      <Region from="157" to="167" loc="I"/>
      <Region from="168" to="185" loc="M"/>
      <Region from="186" to="190" loc="O"/>
      <Region from="191" to="209" loc="M"/>
      <Region from="210" to="220" loc="I"/>
      <Region from="221" to="245" loc="M"/>
      <Region from="246" to="310" loc="O"/>
      <Region from="311" to="328" loc="M"/>
      <Region from="329" to="392" loc="I"/>
      <Region from="393" to="417" loc="M"/>
      <Region from="418" to="422" loc="O"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="449" loc="I"/>
      <Region from="450" to="468" loc="M"/>
      <Region from="469" to="836" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="84" loc="O"/>
      <Region from="85" to="105" loc="M"/>
      <Region from="106" to="107" loc="I"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="132" loc="O"/>
      <Region from="133" to="153" loc="M"/>
      <Region from="154" to="164" loc="I"/>
      <Region from="165" to="185" loc="M"/>
      <Region from="186" to="189" loc="O"/>
      <Region from="190" to="210" loc="M"/>
      <Region from="211" to="221" loc="I"/>
      <Region from="222" to="242" loc="M"/>
      <Region from="243" to="392" loc="O"/>
      <Region from="393" to="413" loc="M"/>
      <Region from="414" to="422" loc="I"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="447" loc="O"/>
      <Region from="448" to="468" loc="M"/>
      <Region from="469" to="836" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="60" loc="I"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="85" loc="O"/>
      <Region from="86" to="106" loc="M"/>
      <Region from="107" to="108" loc="I"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="133" loc="O"/>
      <Region from="134" to="154" loc="M"/>
      <Region from="155" to="163" loc="I"/>
      <Region from="164" to="184" loc="M"/>
      <Region from="185" to="188" loc="O"/>
      <Region from="189" to="209" loc="M"/>
      <Region from="210" to="224" loc="I"/>
      <Region from="225" to="245" loc="M"/>
      <Region from="246" to="249" loc="O"/>
      <Region from="250" to="270" loc="M"/>
      <Region from="271" to="281" loc="I"/>
      <Region from="282" to="302" loc="M"/>
      <Region from="303" to="306" loc="O"/>
      <Region from="307" to="327" loc="M"/>
      <Region from="328" to="397" loc="I"/>
      <Region from="398" to="418" loc="M"/>
      <Region from="419" to="422" loc="O"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="452" loc="I"/>
      <Region from="453" to="473" loc="M"/>
      <Region from="474" to="836" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="135" loc="O"/>
      <Region from="136" to="155" loc="M"/>
      <Region from="156" to="165" loc="I"/>
      <Region from="166" to="185" loc="M"/>
      <Region from="186" to="218" loc="O"/>
      <Region from="219" to="238" loc="M"/>
      <Region from="239" to="265" loc="I"/>
      <Region from="266" to="285" loc="M"/>
      <Region from="286" to="307" loc="O"/>
      <Region from="308" to="327" loc="M"/>
      <Region from="328" to="392" loc="I"/>
      <Region from="393" to="412" loc="M"/>
      <Region from="413" to="422" loc="O"/>
      <Region from="423" to="442" loc="M"/>
      <Region from="443" to="452" loc="I"/>
      <Region from="453" to="472" loc="M"/>
      <Region from="473" to="836" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="84" loc="O"/>
      <Region from="85" to="105" loc="M"/>
      <Region from="106" to="107" loc="I"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="135" loc="O"/>
      <Region from="136" to="156" loc="M"/>
      <Region from="157" to="167" loc="I"/>
      <Region from="168" to="188" loc="M"/>
      <Region from="189" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="271" loc="I"/>
      <Region from="272" to="292" loc="M"/>
      <Region from="293" to="307" loc="O"/>
      <Region from="308" to="328" loc="M"/>
      <Region from="329" to="388" loc="I"/>
      <Region from="389" to="409" loc="M"/>
      <Region from="410" to="421" loc="O"/>
      <Region from="422" to="442" loc="M"/>
      <Region from="443" to="452" loc="I"/>
      <Region from="453" to="473" loc="M"/>
      <Region from="474" to="836" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region from="1" to="21" loc="S"/>
      <Region from="1" to="21" loc="S"/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="21" loc="S"/>
      <Region from="22" to="91" loc="I"/>
      <Region from="92" to="114" loc="M"/>
      <Region from="115" to="133" loc="O"/>
      <Region from="134" to="156" loc="M"/>
      <Region from="157" to="162" loc="I"/>
      <Region from="163" to="185" loc="M"/>
      <Region from="186" to="189" loc="O"/>
      <Region from="190" to="209" loc="M"/>
      <Region from="210" to="221" loc="I"/>
      <Region from="222" to="244" loc="M"/>
      <Region from="245" to="310" loc="O"/>
      <Region from="311" to="328" loc="M"/>
      <Region from="329" to="392" loc="I"/>
      <Region from="393" to="415" loc="M"/>
      <Region from="416" to="424" loc="O"/>
      <Region from="425" to="444" loc="M"/>
      <Region from="445" to="450" loc="I"/>
      <Region from="451" to="468" loc="M"/>
      <Region from="469" to="836" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6b85_J">
      <ConstraintRegion from="1" to="8" loc="I" subId="16988111" subSource="6b85_J"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988112" subSource="6b85_J"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988113" subSource="6b85_J"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988115" subSource="6b85_J"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988117" subSource="6b85_J"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988121" subSource="6b85_D"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988123" subSource="6b85_D"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988125" subSource="6b85_D"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988127" subSource="6b85_D"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988129" subSource="6b85_D"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988134" subSource="6b85_E"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988135" subSource="6b85_E"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988137" subSource="6b85_E"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988139" subSource="6b85_E"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988141" subSource="6b85_E"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988147" subSource="6b85_F"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988149" subSource="6b85_F"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988152" subSource="6b85_F"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988155" subSource="6b85_F"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988158" subSource="6b85_F"/>
    </Constraint>
  </Constraints>
</HtpItem>
