BIG3_HUMAN
Brefeldin A-inhibited guanine nucleotide-exchange protein 3
MEEILRKLQKEASGSKYKAIKESCTWALETLGGLDTIVKIPPHVLREKCL
LPLQLALESKNVKLAQHALAGMQKLLSEERFVSMETDSDEKQLLNQILNA
VKVTPSLNEDLQVEVMKVLLCITYTPTFDLNGSAVLKIAEVCIETYISSC
HQRSINTAVRATLSQMLSDLTLQLRQRQENTIIENPDVPQDFGNQGSTVE
SLCDDVVSVLTVLCEKLQAAINDSQQLQLLYLECILSVLSSSSSSMHLHR
RFTDLIWKNLCPALIVILGNPIHDKTITSAHTSSTSTSLESDSASPGVSD
HGRGSGCSCTAPALSGPVARTIYYIAAELVRLVGSVDSMKPVLQSLYHRV
LLYPPPQHRVEAIKIMKEILGSPQRLCDLAGPSSTESESRKRSISKRKSH
LDLLKLIMDGMTEACIKGGIEACYAAVSCVCTLLGALDELSQGKGLSEGQ
VQLLLLRLEELKDGAEWSRDSMEINEADFRWQRRVLSSEHTPWESGNERS
LDISISVTTDTGQTTLEGELGQTTPEDHSGNHKNSLKSPAIPEGKETLSK
VLETEAVDQPDVVQRSHTVPYPDITNFLSVDCRTRSYGSRYSESNFSVDD
QDLSRTEFDSCDQYSMAAEKDSGRSDVSDIGSDNCSLADEEQTPRDCLGH
RSLRTAALSLKLLKNQEADQHSARLFIQSLEGLLPRLLSLSNVEEVDTAL
QNFASTFCSGMMHSPGFDGNSSLSFQMLMNADSLYTAAHCALLLNLKLSH
GDYYRKRPTLAPGVMKDFMKQVQTSGVLMVFSQAWIEELYHQVLDRNMLG
EAGYWGSPEDNSLPLITMLTDIDGLESSAIGGQLMASAATESPFAQSRRI
DDSTVAGVAFARYILVGCWKNLIDTLSTPLTGRMAGSSKGLAFILGAEGI
KEQNQKERDAICMSLDGLRKAARLSCALGVAANCASALAQMAAASCVQEE
KEEREAQEPSDAITQVKLKVEQKLEQIGKVQGVWLHTAHVLCMEAILSVG
LEMGSHNPDCWPHVFRVCEYVGTLEHNHFSDGASQPPLTISQPQKATGSA
GLLGDPECEGSPPEHSPEQGRSLSTAPVVQPLSIQDLVREGSRGRASDFR
GGSLMSGSSAAKVVLTLSTQADRLFEDATDKLNLMALGGFLYQLKKASQS
QLFHSVTDTVDYSLAMPGEVKSTQDRKSALHLFRLGNAMLRIVRSKARPL
LHVMRCWSLVAPHLVEAACHKERHVSQKAVSFIHDILTEVLTDWNEPPHF
HFNEALFRPFERIMQLELCDEDVQDQVVTSIGELVEVCSTQIQSGWRPLF
SALETVHGGNKSEMKEYLVGDYSMGKGQAPVFDVFEAFLNTDNIQVFANA
ATSYIMCLMKFVKGLGEVDCKEIGDCAPAPGAPSTDLCLPALDYLRRCSQ
LLAKIYKMPLKPIFLSGRLAGLPRRLQEQSASSEDGIESVLSDFDDDTGL
IEVWIILLEQLTAAVSNCPRQHQPPTLDLLFELLRDVTKTPGPGFGIYAV
VHLLLPVMSVWLRRSHKDHSYWDMASANFKHAIGLSCELVVEHIQSFLHS
DIRYESMINTMLKDLFELLVACVAKPTETISRVGCSCIRYVLVTAGPVFT
EEMWRLACCALQDAFSATLKPVKDLLGCFHSGTESFSGEGCQVRVAAPSS
SPSAEAEYWRIRAMAQQVFMLDTQCSPKTPNNFDHAQSCQLIIELPPDEK
PNGHTKKSVSFREIVVSLLSHQVLLQNLYDILLEEFVKGPSPGEEKTIQV
PEAKLAGFLRYISMQNLAVIFDLLLDSYRTAREFDTSPGLKCLLKKVSGI
GGAANLYRQSAMSFNIYFHALVCAVLTNQETITAEQVKKVLFEDDERSTD
SSQQCSSEDEDIFEETAQVSPPRGKEKRQWRARMPLLSVQPVSNADWVWL
VKRLHKLCMELCNNYIQMHLDLENCMEEPPIFKGDPFFILPSFQSESSTP
STGGFSGKETPSEDDRSQSREHMGESLSLKAGGGDLLLPPSPKVEKKDPS
RKKEWWENAGNKIYTMAADKTISKLMTEYKKRKQQHNLSAFPKEVKVEKK
GEPLGPRGQDSPLLQRPQHLMDQGQMRHSFSAGPELLRQDKRPRSGSTGS
SLSVSVRDAEAQIQAWTNMVLTVLNQIQILPDQTFTALQPAVFPCISQLT
CHVTDIRVRQAVREWLGRVGRVYDIIV
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
