PDE6_DROPE
cGMP-specific 3',5'-cyclic phosphodiesterase
MHELGTRQRPLSSSSSSSSSSNMTDVSAAAGGATAPAETAATSSSASKPL
TNGANKTSTAMAAPTTTPTTAATAAGAAEAGAIASVAGISNQVKLEHHHR
QSNNNRPVAPYPPVPAAKPKPTPTPTAESKFKSTSREVDVALRPTPARSS
TISPGVSIHTQTIQQESSSAKPGMSSSSSSAQQDVDEVARLFEEKPEAFE
KWLTERAPPEALSRLQEFIESRKPLKRPSVTSDLFQQWMSASPTVQQKSP
RSLSNSSASSTLPECRRHLMDLDEGELFMELIRDVANELDIDVLCHKILV
NVGLLTHADRGSLFLAKGTPHNKYLVAKLFDVTQKTALKDAVTRASAEEI
IIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPI
CNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEM
SVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLNCERCSVFLV
DLDCCEASHLEKIIEKPNQPEQRPTRAIMPGDSFDEKKMRNRFTVLFELG
GEYQAASVSRPSKTELSTSTLAQIAQFVATTGQTVNICDVHEWVRDHNQI
RAESEIDSTQAILCMPIVNAQKIVIGVAQLINKANGVPFTESDASIFEAF
AIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDAI
AEAESYNLYSFTFTDFELVDDDTCRAVLRMFLQCNLVSQFQIPYDVLCRW
VLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVA
CLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNN
IFQPRTTRTFLLLARRFLRFDLLPFRAFTRALRPLVRPLLELDVLELPDP
SRIFLLTVYLRLVTRTIFLPPPEDEEEEDEVEDSVVLVVASVVVVVAVAA
SVVLKAELDVEALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVEN
GEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGD
LEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITP
LYEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAGCADEEIKDIE
FTVTTLNCNQQAQHGAGAGGDDSHTPEHQRSGSRLSMKKTGALGKAVRSK
LSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPSQPPHAGGSVGRM
SASSSTSSAGTVVDKSKKRSKLCSLL
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
