ROS1_MOUSE
Proto-oncogene tyrosine-protein kinase ROS
MKNICWLTLKLVKFVVLGCIIWISVAQSTVLSSCLTSCVTNLGRQLDSGT
RYNLSEACIHGCQFWNSVDQETCALKCNDTYATICERESCEVGCSNAEGS
YEEEVLESTELPTAPFASSIGSHGVTLRWNPANISGVKYIIQWKYAQLPG
SWTFTETVSKLSYTVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHP
YGVPETAPLILNMESWSPDTVEVSWAPPHFPGGPILGYNLRLISKNQKLD
SGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESTVTTPSPSVQEEE
QWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIHHNITGISVYAQQQVVYFS
EGTVIWMKGAANMSDVSDLRIFYQGSGLVSSISIDWLYQRMYFIMDKLVY
VCELKNCSNLEEITPFSLIAPQKVVVDSYNGYLFYLLRDGIYRVNLPLPS
GRDTKAVRIVESGTLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSAFHRV
LPWVPLVTVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEF
GFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWTPPALAIGASPSA
WQNWTYEVKVYSQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSP
KGPGPWSAPSVGTTLVPATEPPFIMAVKEDGLWSKPLCSFGPGEFLSSDV
GNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHIPSIVGAGALAFE
WLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDSVGGYLYWT
TLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQC
IHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSGRLFWINGFRII
TAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIPDPVQES
SFRIEGHTSSFQILWNEPPAVDWGIVFYSVEFSTHSKFLIIEQQSLPIFT
VEGLEPYTLFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSS
GRYTKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSA
SVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPCP
YLISLLGNKIVFLDMDQNQVLWTFSLEGDVSTVGYTTDDEMGYFAQGDTL
FLLNLRNHSSSKLFQDALVSDIRVIAVDWIARHLYFALKASQNGTQIFNV
DLEHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDLGHQMFYCNI
SNHTSQHVLQPKASNQHGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFT
KRQEIWAMDLEGCQCWKVIMVPTIPGKRIISLTVDGEFIYWIMKTKDDAQ
IYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDMVEATI
LYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKM
LESQENVARIEGLQPFSMYMIQIAVKNYYSEPLEHLPLGKEIQGQTKSGV
PGAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETP
LRQGEFPSAKLSLLITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMFD
TPEKPSALVPENTSLQLDWKARSNVNLTGFWFELQKWKYNEFYHVKASCS
QGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPG
IPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVF
NGSCSSICTWRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWI
TETSFILTIIVGIFLVATVPLTFVWHRSLKSHKASKEGLSVLNDNDKELA
ELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPREKLSLRLLLGSGAFG
EVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHP
NILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLV
ELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAR
EIYKNDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTL
GHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMSQCWAQEPDQRPT
FHNIQNQLQLFRNVFLNNVSHCGEAAPTGGVINKGFEGEDDEMVTLNSDD
TMPVALMETKNQEGLNYMVLATKCSQGEGSYEGPLGPKELGSCDLKKDKK
QPQADKDFCQEP
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
