ROS1_RAT
Proto-oncogene tyrosine-protein kinase ROS
MKRIRWLTPKPATFVVLGCVWISVAQGTILSSCLTSCVTNLGRQLDSGTR
YNLSEACIQGCQFWNSIDQEKCALKCNDTYVTICERESCEVGCSNAEGSY
EEEVLDNTELPTAPFASSIGSNGVTLRWNPANISGVKYIIQWKYAQLPGS
WAYTETVSKLSYMVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPY
GVPETAPFITNIESSSPDTVEVSWAPPYFPGGPILGYNLRLISKTQKLDS
GTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESMITTPSPAVQEEEQ
WLFLSRKTSLRKRSLKYLVDEAHCLWSDAIRHNITGISVNTQQEVVYFSE
GTIIWMKGAANMSDVSDLRIFYRGSALVSSISVDWLYQRMYFIMDNRVHV
CDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIYRVHLPLPSV
RDTKAVRIVESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVL
PWVPLADVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFG
FGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWKPPILAIGASPSAW
QNWTYEVKVSSQDILETTQVFLNISRTVLNVPKLQSSTKYMVSVRASSPK
GPGPWSEPSVGTTLVPATEPPFIMAVKEDGLWSKPLSSFGPGEFLSSDVG
NVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHISSIAGACALAFEW
LGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYWTT
LYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCI
HLYTAVLRGWSGADATITEFAAWSTSEISQNALMYYSGRLFWINGFRIIT
AQEIGQRTSVSVSEPGKFNQFTIIQTSLKPLPGNFSSTPTVIPDSVQESS
FRIEGHTSSFRILWNEPPAVDWGIVFYSVEFSAHSKFLAIEQQSLPVFTV
EGLEPYALFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSLG
RYTRKNEVVVEFRWNKPKHENGVLTKSEIFYHISKQSGTNKSTEDWVSVS
VTPPVMSFQLEAMSPGYIVSFQVRVFTSKGPGPFSDIVMSKTSEIKPCPY
LISLLGNKIEFLDMDQNQVVWTFSLEGAVSTVGYTADDEMGYFAQGDALF
LLNLHNHSSSKLFQDVLASDIAVIAVDWIARHLYFALKASQDGTQIFDVD
LEHKVKSPREVKICKSHTAIISFSMYPLLSRLYWTEVSDLGYQMFYCNIS
SHTLHHVLQPKASNQHGRRQCSCNVTESELSGAMTVDTSDPDRPWIYFTK
QQEIWAMDLEGCQCWKVIMVPATPGKRIISLTVDGEFIYWITTMKDDTEI
YQAKKGSGAILSQVKAPRSKHILAYSSALQPFPDKAYLSVASNMVEASIL
NATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSDRKHNML
ESQENVARIEGLQPFSTYVIQIAVKNYYSDPLEHLSLGKEIQGKTKSGVP
GAVCHINATVLSDTSLLVFWTESHKPNGPKELVRYQLVMSYLAPIPETPL
RQDEFPSARLSLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDT
PEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKWKYSEFYHVKASCSQ
GPVYVCNIANLQPYTPYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGI
PKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSISNDSRDQSLRWTAVFN
GSCSSICTWRSKNLKGTFQFRAVASNAIGFGEYSEISEDITLVEDGFWIT
ETSFILTIIVGIFLVATVPLTFVWHRSLKNHKATKEGLSVLNDNDQELAE
LRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGE
VYEGTAVDILGRGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPN
ILKQLGVCLLSEPQYIILELMEGGDLLSYLRKARGTTLSGPLLTLADLVE
LCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLARE
IYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLG
HQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTF
YNIQDQLQLFRNVSLNNVSHCGQAAPAGGVINKGFEGEDNEMATLNSDDT
MPVALMETRNQEGLNYMVLATKCSQSEDRYEGPLGSKESGLHDLKKDERQ
PADKDFCQQPQVAYGSPGHSEGLNYACLAHSGHGDVSE
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
Legend:
Inside
Membrane
Outside
Re-entrant loop
Beta barrel inside
Periplasm
Interfacial helix
